Molecular aspects of immune recognition of cytomegalovirus.


:The studies discussed in this presentation have shown that CD8 T lymphocytes have a primary role in conferring resistance to MCMV in the immunocompetent BALB/c mouse. In the presence of selective CD8 deficiency, however, other mechanisms, apparently mediated by the CD4 T-cell subset, contribute in a compensatory fashion to antiviral immunity. The protective CTL response to MCMV, at least in BALB/c mice, is elicited by a single epitope encoded by the major ie 1 and expressed in protein pp89. The epitope itself contains 18 amino acids, only five of which are the minimum for CTL recognition. Substitutions within a nonapeptide sequence that is part of the pp89 epitope identified two positions that are critical for TCR binding by clone IE1 CTLs. Polyclonal CTLs, in contrast, respond to either the native nonapeptide or any of the substituted variants that were tested, which suggests a certain degree of degeneracy in the specificity of the physiologic immune response.


Transplant Proc


Koszinowski UH


Has Abstract


1991-06-01 00:00:00


70-3, discussion 74


3 Suppl 3








  • Almost 50,000 volunteers participate at Redome, the Brazilian Bone Marrow Donor Registry.

    abstract::Striking progress has been observed in the number of volunteer donors for hematopoietic stem cell transplantation in the last years in Brazil. By the end of 1998, the number of donors barely reached 4200 but it has grown progressively. It was close to 48,000 by the end of May 1993. It is possible to notice a steady in...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Moraes JR,Alencar IS,Moraes ME,Pereira NF,Pasquini R,Tabak DG

    更新日期:2004-05-01 00:00:00

  • The FcgammaRIIa polymorphism in patients with chronic kidney graft rejection.

    abstract::The FcgammaRIIa receptors, which provide a crucial link between cellular and humoral components of the immune response, display allelic polymorphism. Individuals are homozygous for either arginine 131 (RR131) or histidine 131 (HH131) or are heterozygous for these two alleles (RH131). The HH131 genotype binds human IgG...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pawlik A,Florczak M,Bak L,Dabrowska-Zamojcin E,Rozanski J,Domanski L,Gawronska-Szklarz B

    更新日期:2004-06-01 00:00:00

  • Global cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation.

    abstract:UNLABELLED:A primary reason to eliminate corticosteroids from immunosuppressive regimens in solid organ transplant recipients is improved cardiovascular risk profiles. Although a number of studies have documented that corticosteroid withdrawal (CSWD) regimens reduce hypertension, hyperlipidemia, diabetes, and weight ga...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Rogers CC,Alloway RR,Boardman R,Trofe J,Hanaway MJ,Alexander JW,Roy-Chaudhury P,Buell JF,Thomas M,Susskind B,Woodle ES

    更新日期:2005-03-01 00:00:00

  • Antigen sampling on the Peyer's patches in a murine small bowel transplantation model.

    abstract:AIM:This study investigated changes in the mucosal barrier of transplanted intestines with particular emphasis on antigen sampling by Peyer's patches (PPs). METHODS:Heterotopic small bowel transplantation (SBTx) was performed as described previously. C57BL/6 mice were used as donors and BALB/c (allogeneic) or C57BL/6 ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ping X,Li Y,Li J

    更新日期:2010-11-01 00:00:00

  • Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging.

    abstract::One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. We have developed a quantitative method to diagnose rejection and acute tubular necrosis (ATN) by comparing regions of interest drawn on allograft scintigraphs at different...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lopes de Souza SA,Barbosa da Fonseca LM,Torres Gonçalves R,Salomão Pontes D,Holzer TJ,Proença Martins FP,Gutfilen B

    更新日期:2004-12-01 00:00:00

  • Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients.

    abstract:OBJECTIVES:Alloreactive T cells recognize antigens via direct and indirect pathways. The competency of costimulatory molecules on antigen-presenting cells (APC) is important. An active form of vitamin D (1,25(OH)(2)D(3), calcitriol) inhibits APC cell maturation and expression of costimulatory molecules. Herein we studi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Ardalan MR,Maljaei H,Shoja MM,Piri AR,Khosroshahi HT,Noshad H,Argani H

    更新日期:2007-05-01 00:00:00

  • Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.

    abstract:BACKGROUND:The prolonged survival time after liver transplantation (LTX) creates the possibility of the occurrence and development of complications in the late post-transplantation period. Deterioration of renal function is 1 of these complications. The nephrotoxicity of calcineurin inhibitors (CNIs) and their metaboli...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hryniewiecka E,Zegarska J,Zochowska D,Pączek L

    更新日期:2020-10-01 00:00:00

  • Renal biopsy donor group: the influence of glomerulosclerosis on transplant outcomes.

    abstract::The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P < .001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P < .001) to...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cicciarelli J,Cho Y,Mateo R,El-Shahawy M,Iwaki Y,Selby R

    更新日期:2005-03-01 00:00:00

  • Hepatic artery thrombosis after orthotopic liver transplantation: 3 patients with collateral formation and conservative treatment.

    abstract::Hepatic artery thrombosis (HAT), a serious complication after orthotopic liver transplantation (OLT), can lead to patient death in the absence of revascularization or retransplantation. Herein we have presented clinical characteristics, imaging findings, and long-term outcomes of 3 OLT patients with HAT who were treat...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Fouzas I,Sklavos A,Bismpa K,Paxiadakis I,Antoniadis N,Giakoustidis D,Katsiki E,Tatsou N,Mouloudi E,Karapanagiotou A,Tsitlakidis A,Karakatsanis A,Patsiaoura K,Petridis A,Gakis D,Imvrios G,Papanikolaou V

    更新日期:2012-11-01 00:00:00

  • Influence of pancreas and kidney transplant function on recipient survival.

    abstract::The aim of this study was to evaluate long-term survival after simultaneous pancreas and kidney (SPK) transplantation in relation to function of both grafts. Among 67 recipients who received SPK transplants between 1988 and 2004, 35 had follow-up longer than 18 months, and were divided into: group I (n = 20), recipien...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Szmidt J,Grochowiecki T,Gałazka Z,Nazarewski S,Madej K,Frunze S,Chudziński W,Durlik M,Paczek L,Jakimowicz T,Rongies W,Kański A

    更新日期:2006-01-01 00:00:00

  • Predestinating Role of Cardiac Ganglia on Heart Life Expectancy in Rabbits After Brain Death Following Subarachnoid Hemorrhage: An Experimental Study.

    abstract:BACKGROUND:Cardiac ganglia are rechargeable batteries of the heart. The essential role of cardiac ganglia on cardiac life expectancy has not been examined following brain death. The aim of this study was to determine cardiac ganglia numbers and neuron density following subarachnoid hemorrhage (SAH). METHODS:Twenty-fiv...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Aydin MD,Acikel M,Aydin N,Aydin ME,Ahiskalioglu A,Atalay C,Ahiskalioglu EO,Erdogan F,Sipal S

    更新日期:2020-01-01 00:00:00

  • Selective use of expanded criteria donors for renal transplantation with good results.

    abstract::Increasing demand for renal transplants has stimulated expanded criteria for the use of deceased donors. Recently an official category of "Expanded Criteria Donors" (ECD) was designated by UNOS. This category included any deceased donor (1) greater than age 60 years or (2) age 50 to 59 years with any two of: (a) creat...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Greenstein SM,Schwartz G,Schechner R,Pullman J,Jackness C,Tellis V

    更新日期:2006-12-01 00:00:00

  • Thromboelastography as a Predictor of Outcomes Following Liver Transplantation.

    abstract:BACKGROUND:Thromboelastography (TEG) has been used perioperatively during liver transplantation (LT) to provide a real-time global hemostasis assessment for targeted blood product replacement. We aimed to analyze the relationship between post-LT TEG results and outcomes. METHODS:We retrospectively analyzed patients un...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Trautman CL,Palmer WC,Taner CB,Canabal JM,Getz T,Goldman A,Heckman MG,Diehl NN,Lee DD,Stancampiano FF

    更新日期:2017-11-01 00:00:00

  • Incidence and risk factors of new-onset diabetes mellitus after renal transplantation.

    abstract:PURPOSE:New-onset diabetes mellitus (PTDM), a major metabolic complication after renal transplantation, examined for incidence and risk factors. METHODS:The records of 358 renal transplant recipients with functioning grafts, from 1986 to 2006, were categorized into two groups according to the usage of tacrolimus (FK):...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chien YS,Chen YT,Chuang CH,Cheng YT,Chuang FR,Hsieh H

    更新日期:2008-09-01 00:00:00

  • Factors influencing the vaccinia-specific cytotoxic response of thymocytes from normal and chimeric mice.

    abstract::Following adoptive transfer into irradiated recipients, thymocytes can be induced to respond strongly to vaccinia virus. High levels of cytotoxic T-lymphocyte (CTL) activity may be generated from thymus, but not from spleen, of 3-day-old mice. The capacity of thymocytes to differentiate into effector CTL tends to be l...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Doherty PC,Schwartz DH,Bennink JR,Korngold R

    更新日期:1981-12-01 00:00:00

  • Psychometric Characteristics of the Attitude Questionnaire Toward the Donation of Organs for Transplant (PCID-DTO-RIOS).

    abstract:INTRODUCTION:Most psychosocial attitude studies for donors are not evaluated and are not valid. Validated questionnaires are necessary to compare results and guarantee that they measure what they are intended to measure. OBJECTIVE:To analyze the psychometric characteristics of the attitude questionnaire toward the don...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ríos A,López-Navas AI,De-Francisco C,Sánchez Á,Hernández AM,Ramírez P,Parrilla P

    更新日期:2018-03-01 00:00:00

  • Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus.

    abstract:OBJECTIVE:To establish 2 models of long-term chronic allograft rejection (CR) of orthotopic small bowel transplantation (OSBT) using cyclosporine (CsA) or tacrolimus (FK506). METHODS:F344 and Lewis rats served as donors and recipients respectively for OSBT. In the study 1, the rat was administered CsA (5 mg/kg/d) intr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Li Y,Zhu Y,Wang J,Wei W,Wu B,Li J

    更新日期:2013-06-01 00:00:00

  • Diagnostic performance of serum cystatin C and serum creatinine in the prediction of chronic kidney disease in renal transplant recipients.

    abstract:BACKGROUND:Chronic kidney disease (CKD) has adverse impacts on mortality and morbidity of renal transplant recipients. Serum cystatin C (sCysC) is a novel marker in predicting the CKD. We therefore compare sCysC and serum creatinine (sCr) with the aim of improving the detection of CKD in renal transplant recipients. M...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tsai JP,Wu SW,Hung TW,Kao WT,Hong CL,Lian JD,Chang HR

    更新日期:2010-12-01 00:00:00

  • Gastrointestinal complications of hepatic transplantation.

    abstract::In this series of 150 orthotopic hepatic transplants, clinically significant gastrointestinal hemorrhage occurred in 34 patients (23%). Five patients (15%) survived this complication. Enteric perforations occurred in 20 patients following 198 biliary-enteric procedures. Only one patient survived. Enteric perforations ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Koep LJ,Starzl TE,Weil R 3rd

    更新日期:1979-03-01 00:00:00

  • Stress dose steroids in renal transplant patients undergoing lymphocele surgery.

    abstract::The requirement for perioperative stress dose steroids (SDS) in patients on long-term steroid therapy is controversial, but SDS are given during perioperative care. Studies focusing on surrogate outcomes like cortisol levels indicate a possible requirement for SDS, but clinical results are sparse. We retrospectively c...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mathis AS,Shah NK,Mulgaonkar S

    更新日期:2004-12-01 00:00:00

  • Emergency organ transplantation in Spain: liver emergency and outcomes.

    abstract::The 2 main indications for emergency liver transplantation are severe acute hepatic insufficiency and emergency retransplantation. In Spain, since the creation of the National Transplant Organisation (NTO), known as "the Spanish model," there have been high rates of donation, with a mean of 33.9 donors per million inh...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sanchez-Bueno F,Cuende N,Matesanz R,Parrilla P

    更新日期:2005-11-01 00:00:00

  • The outcome of diverticulosis in kidney recipients with polycystic kidney disease.

    abstract:INTRODUCTION:Diverticulosis is a common finding in autosomal-dominant polycystic kidney disease (ADPKD). To avoid the serious complications of diverticulosis after kidney transplantation, some policies have recommended aggressive actions, such as elective colectomy. These policies are not widely agreed upon. This contr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pourfarziani V,Mousavi-Nayeeni SM,Ghaheri H,Assari S,Saadat SH,Panahi F,Noorbala MH,Vasei A,Norouzi AR,Simforoosh N

    更新日期:2007-05-01 00:00:00

  • Invasive pulmonary aspergillosis after solid organ transplantation: diagnosis and treatment based on 28 years of transplantation experience.

    abstract::Invasive pulmonary aspergillosis (IPA) is a serious and lethal complication among organ transplant recipients. This report described the clinical manifestations and treatment of IPA over a 28-year period. From January 1979 to December 2007, 3215 organ transplant patients (2954 kidney and 261 liver recipients) were enr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ju MK,Joo DJ,Kim SJ,Chang HK,Kim MS,Kim SI,Kim YS

    更新日期:2009-01-01 00:00:00

  • Influence of Body Mass on Kidney Graft Function in Patients After Kidney Transplantation.

    abstract:BACKGROUND:Increasing evidence shows that body mass may play a role in complications after kidney transplantation and influence graft and patient survival. The aim of this study was to analyze the association between graft function and both the body mass and adipokines (leptin, visfatin, adiponectin) in kidney transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Małgorzewicz S,Dębska-Slizień A,Czajka B,Owczarzak A,Rutkowski B

    更新日期:2016-06-01 00:00:00

  • Kidney transplantation from marginal donors.

    abstract:AIM:The increasing demand for transplantation and the shortage of available organs limit the success of organ transplant programs. The use of marginal donors to expand the donor pool is receiving increased attention. We reviewed a 28-month experience of kidney transplants from marginal donors to assess the impact on pa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Veroux P,Puliatti C,Veroux M,Cappello D,Macarone M,Puliatti D,Vizcarra D

    更新日期:2004-04-01 00:00:00

  • The protective effect of curcumin on ischemia-reperfusion-induced liver injury.

    abstract:OBJECTIVE:Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. M...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lin CM,Lee JF,Chiang LL,Chen CF,Wang D,Su CL

    更新日期:2012-05-01 00:00:00

  • Deep vein thrombosis during rabbit antithymocyte globulin administration.

    abstract:INTRODUCTION:Rabbit antithymocyte globulin (RATG) is recommended for central administration, and no evidence justifies the common practice of adding heparin to the bag, but the evaluation of thrombocytopenia may be complicated by coadministration. We recently phased out the use of heparin in RATG in our kidney and kidn...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mathis AS,Rao V

    更新日期:2004-12-01 00:00:00

  • Approach of the Clinicians Practicing in Intensive Care Units to Brain Death Diagnosis and Training Expectations in Turkey: A Web-Based Survey.

    abstract:BACKGROUND:For health professionals, recognizing and diagnosing brain death is vital for the development of organ transplantation. However, cadaveric organ donation rates remain insufficient, and this problem has become one of the most serious obstacles in the treatment of end-organ failure. OBJECTIVES:This study exam...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ferhatoglu SY,Ferhatoglu MF,Gurkan A

    更新日期:2020-12-01 00:00:00

  • De Novo Malignancy Following Adult-to-Adult Living Donor Liver Transplantation Focusing on Posttransplantation Lymphoproliferative Disorder.

    abstract:OBJECTIVE:In patients with living donor liver transplantation (LDLT), late-onset complications sometimes develop because of long-term use of immunosuppressive drugs. One of the immunosuppressive drug-related complications is de novo malignancies resulting in reduced survival. PATIENTS AND METHODS:Among 153 patients un...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mizuno S,Hayasaki A,Ito T,Fujii T,Iizawa Y,Kato H,Murata Y,Tanemura A,Kuriyama N,Azumi Y,Kishiwada M,Usui M,Sakurai H,Isaji S

    更新日期:2018-11-01 00:00:00

  • Use of Georges Lopez Institute Preservation Solution IGL-1 in Pancreas Transplantation: A Series of 47 Cases.

    abstract:BACKGROUND:Graft preservation continues to be one of the main pillars of pancreas transplantation (PT). Surgical complications, possibly caused or facilitated by organ damage during preservation, continue to occur more frequently after PT than for any other abdominal organ. During the past few years, the Georges Lopez ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Igreja MR,Wiederkehr JC,Wiederkehr BA,Maykon Massutti A,de Aguiar Wiederkehr H

    更新日期:2018-04-01 00:00:00