Smoking following renal transplantation in Hungary and its possible deleterious effect on renal graft function.

Abstract:

:Smoking is a known risk factor for kidney damage and also influences graft function following renal transplantation. Because smoking habits following kidney transplantation are not systematically evaluated, we analyzed them in a single center in Hungary. The survey was conducted among 402 randomly selected kidney graft recipients. We assessed smoking-related questions as well as clinical kidney disease and transplantation data. Posttransplantation renal function was analyzed based on serum creatinine values at 1 month and at 3 years after transplantation. In our study 25% (n = 102) of patients continued to smoke after transplantation. Smokers who received grafts displayed a significantly younger age compared with nonsmokers (40.1 +/- 13.4 vs 47.1 +/- 12.7 years; P < .001) independent of underlying kidney disease. Posttransplantation kidney function in smokers did not differ at 1 month after engraftment, but was significantly impaired at 3 years as assessed based on serum creatinine levels: 138.9 +/- 42.4 versus 128.4 +/- 48.5 micromol/L (P < .05). Decrease of renal function correlated with smoking intensity defined in pack-years (r(2) = 0.102; P < .05). Smoking is common following kidney transplantation in Hungary and might represent a risk factor for kidney damage following renal transplantation. Therefore, effective tobacco-dependence treatment is necessary in this patient population.

journal_name

Transplant Proc

authors

Gombos P,Langer RM,Korbely R,Varga M,Kaposi A,Dinya E,Müller V

doi

10.1016/j.transproceed.2010.05.143

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

2357-9

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)00871-7

journal_volume

42

pub_type

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