Abstract:
BACKGROUND:Clinical studies of uterus transplantation have been performed to treat uterine factor infertility. Because the uterus is a pelvic visceral organ, the method of perfusion for the procurement of vital organs from a brain-dead donor should be modified for removal of the uterus. Herein, we report the results of a preliminary study in cynomolgus monkeys of a new perfusion method for uterus transplantation with assumed procurement of a uterus from a brain-dead donor. METHODS:Cynomolgus monkeys were used; thoracolaparotomy was performed on the donor. A perfusion catheter was then placed into the unilateral femoral artery and/or external iliac artery. Cross-clamping was performed for the aorta under the diaphragm and the inferior vena cava was divided in the pleural space. The perfusion solution was then administered via the catheter to perfuse all organs in the abdominal cavity, including those in the pelvic cavity. After the perfusion, gross observation and histopathological examination of abdominal organs were conducted. RESULTS:Gross findings showed that all abdominal organs turned white in all specimens, indicating favorable perfusion of the uterus and all other organs in the abdomen. Pathological findings showed that almost no hemocytes were observed in the vessels of each organ. CONCLUSIONS:With perfusion via the femoral artery and/or external iliac artery, all organs in the abdominal cavity, including the uterus, could be perfused. It was suggested that this technique could be useful for uterus transplantation assuming the procurement of a uterus from a brain-dead donor.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Kisu I,Kato Y,Yamada Y,Matsubara K,Obara H,Emoto K,Adachi M,Umene K,Nogami Y,Banno K,Kitagawa Y,Aoki Ddoi
10.1016/j.transproceed.2015.12.105subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1266-9issue
4eissn
0041-1345issn
1873-2623pii
S0041-1345(16)00224-4journal_volume
48pub_type
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journal_title:Transplantation proceedings
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journal_title:Transplantation proceedings
pub_type: 杂志文章,评审
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章,评审
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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journal_title:Transplantation proceedings
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doi:10.1016/j.transproceed.2012.10.065
更新日期:2013-06-01 00:00:00
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更新日期:2006-11-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2005.06.095
更新日期:2005-09-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2010.08.015
更新日期:2010-10-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2019.04.081
更新日期:2019-10-01 00:00:00