Effects of Ischemic Preconditioning and Postconditioning in a Renal Ischemia-Reperfusion Injury Model: A Comparative Experimental Study in Rats.


BACKGROUND:Ischemia-reperfusion injury is an unavoidable aspect of transplantation, as well as an important cause of acute kidney injury in clinical practice. Pre- and post-ischemic conditioning are strategies that may provide organs with resistance to major ischemic events. This study evaluates the effects of ischemic preconditioning and ischemic postconditioning, either separately or in combination, after an acute ischemia-reperfusion kidney injury. METHODS:Forty Wistar rats received isoflurane anesthesia and were randomized into 5 groups: 1. the sham group underwent laparotomy; 2. the control group underwent laparotomy and 30 minutes of renal ischemia followed by reperfusion; 3. the preconditioning group underwent laparotomy, ischemic preconditioning, and 30 minutes of renal ischemia followed by reperfusion; 4. the preconditioning and postconditioning group underwent laparotomy, ischemic preconditioning, 30 minutes of renal ischemia, and ischemic postconditioning followed by reperfusion; and 5. the postconditioning group underwent laparotomy, 30 minutes of renal ischemia, and ischemic postconditioning followed by reperfusion. Serum analyses of creatinine and neutrophil gelatinase-associated lipocalin (NGAL) were performed, and renal histology was examined 24 hours later. RESULTS:Severe tubular injury and increases in creatinine were observed in all groups except the sham group. The control group and all ischemic conditioning groups were no different in the degree of renal injury and values of NGAL and creatinine after the injury. CONCLUSIONS:Ischemic preconditioning and ischemic postconditioning, together or separately, are unable to preserve kidney function or exert a protective effect against tubular cell injury after an acute ischemia-reperfusion kidney injury.


Transplant Proc


Arantes VM,Bueno RT,Módolo RP,Domingues MAC,de Carvalho LR,do Nascimento Junior P,Módolo NSP




Has Abstract


2018-12-01 00:00:00














  • Experience with single-dose daclizumab in the prevention of acute rejection in heart transplantation.

    abstract:INTRODUCTION:Daclizumab is a monoclonal antibody that binds to the interleukin-2 receptor. It has been used as induction therapy in heart transplantation with two to five repeated administrations over several weeks. The objective of our study was to estimate the efficacy and safety of induction therapy with only one do...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cuppoletti A,Perez-Villa F,Vallejos I,Roig E

    更新日期:2005-11-01 00:00:00

  • Impact of the 2011 Great East Japan Earthquake on the resumption of alcohol consumption after living-donor liver transplantation for alcoholic cirrhosis: a report of two cases.

    abstract::Alcoholic liver disease (ALD) is a leading indication for liver transplantation (LT) in Western countries. The rate of resumption of alcohol abuse is 7% to 95% after LT for ALD. A high prevalence of alcohol abuse has been observed in disaster-exposed populations; however, little is known about the association between ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nakanishi C,Kawagishi N,Sato K,Miyagi S,Takeda I,Ohuchi N

    更新日期:2014-04-01 00:00:00

  • Improvement of mortality rate and decrease in histologic hepatic injury after human cord blood stem cell infusion in a murine model of hepatotoxicity.

    abstract:BACKGROUND AND AIMS:Because of their plasticity potential local and systemic application of cord blood stem cells may represent excellent candidates for cell-based therapeutic strategies in toxic liver injuries. It is already known that intraperitoneal administration of hematopoietic stem cells provides rapid liver hom...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Di Campli C,Piscaglia AC,Rutella S,Bonanno G,Vecchio FM,Zocco MA,Monego G,Michetti F,Mancuso S,Pola P,Leone G,Gasbarrini G,Gasbarrini A

    更新日期:2005-07-01 00:00:00

  • Citrulline evaluation in bowel transplantation.

    abstract:INTRODUCTION:The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation. METHODS:From January 2007 until present, we performed citrulline assays on our small bowel patients. We investigated the correlation of these assays with the rejection statu...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ruiz P,Tryphonopoulos P,Island E,Selvaggi G,Nishida S,Moon J,Berlanga A,Defranc T,Levi D,Tekin A,Tzakis AG

    更新日期:2010-01-01 00:00:00

  • Incidence and risk factors of development of lung tumors after liver transplantation.

    abstract:INTRODUCTION:Lung tumors have been related to tobacco and alcohol. The incidence increases after orthotopic liver transplantation (OLT) especially when it is performed because of alcoholic cirrhosis. PATIENTS AND METHODS:We analyzed the incidence and risk factors for de novo lung tumors among 701 patients who underwen...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jiménez C,Marqués E,Manrique A,Loinaz C,Gómez R,Meneu JC,Abradelo M,Pérez B,Moreno A,García I,Moreno E

    更新日期:2005-11-01 00:00:00

  • Long-term Clinical Significance of Tacrolimus Trough Level at the Early Period After Kidney Transplantation.

    abstract:BACKGROUND:The stable immunosuppressant level at the early period after kidney transplantation (KT) is one of the most important factors for the prognosis of KT. However, the extent of immunosuppression varies according to the policies of each KT center. We investigated the relationship between the clinical outcome and...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Park WY,Paek JH,Jin K,Park SB,Han S

    更新日期:2019-10-01 00:00:00

  • First living related kidney transplantation results in excellent outcomes for small children.

    abstract:OBJECTIVE:The aim of this study was to evaluated the outcomes of living related kidney transplantation in small children. MATERIALS AND METHODS:Ten pediatric patients with body weights less than 10 kg received parental kidney transplants (five mothers and five fathers). An intra-abdominal approach was used in nine chi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Aikawa A,Arai K,Kawamura T,Sugiyama K,Muramatsu M,Itabashi Y,Ohara T,Motoyama O,Hasegawa A

    更新日期:2005-09-01 00:00:00

  • Kidney transplantation from marginal donors.

    abstract:AIM:The increasing demand for transplantation and the shortage of available organs limit the success of organ transplant programs. The use of marginal donors to expand the donor pool is receiving increased attention. We reviewed a 28-month experience of kidney transplants from marginal donors to assess the impact on pa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Veroux P,Puliatti C,Veroux M,Cappello D,Macarone M,Puliatti D,Vizcarra D

    更新日期:2004-04-01 00:00:00

  • Altered expression of hepatocyte growth factor in cardiac allografts of nonhuman primates.

    abstract::Hepatocyte growth factor (HGF) plays a critical role in transplant rejection. Herein we addressed whether HGF expression could be used for accurate and early diagnosis of acute and chronic rejection in cardiac transplantation. We used a heterotopic cardiac transplantation model using nonhuman primates (Macaca fuscata,...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Suzuki J,Kawauchi M,Ogawa M,Isobe M

    更新日期:2006-12-01 00:00:00

  • Approach of the Clinicians Practicing in Intensive Care Units to Brain Death Diagnosis and Training Expectations in Turkey: A Web-Based Survey.

    abstract:BACKGROUND:For health professionals, recognizing and diagnosing brain death is vital for the development of organ transplantation. However, cadaveric organ donation rates remain insufficient, and this problem has become one of the most serious obstacles in the treatment of end-organ failure. OBJECTIVES:This study exam...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ferhatoglu SY,Ferhatoglu MF,Gurkan A

    更新日期:2020-12-01 00:00:00

  • Molecular and phenotypic characteristics of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in transplantation wards.

    abstract:OBJECTIVES:Hospital-acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) frequently causes therapeutic problems and provides information about the epidemiological condition of the ward. MATERIALS AND METHODS:HA-MRSA isolated from patients on transplantation wards in 1991, 1994, 1996, and from 2005 to 2007 we...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mlynarczyk A,Szymanek-Majchrzak K,Grzybowska W,Durlik M,Deborska-Materkowska D,Paczek L,Chmura A,Swoboda-Kopec E,Tyski S,Mlynarczyk G

    更新日期:2014-10-01 00:00:00

  • A case of laryngeal posttransplantation lymphoproliferative disease.

    abstract::The development of posttransplant lymphoproliferative disease (PTLD) is strongly linked to infection with the Epstein-Barr virus (EBV), immunosuppression-state, the type of allograft, and EBV-seronegativity. A 18-month-old girl who had undergone living donor liver transplantation using the left lateral segment from he...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lee HH,Lee DS,Park JH,Lee KW,Kim SJ,Joh JW,Seo JM,Kwon GY,Choe YH,Lee SK

    更新日期:2004-10-01 00:00:00

  • High prevalence of small dense LDL as an underestimated component of heart transplantation-induced dyslipidemia: potential role in graft coronary vasculopathy?

    abstract::Heart transplantation-induced dyslipidemia is a recognized risk factor for cardiac allograft vasculopathy that affects survival prognosis. Beyond increased lipids, low-density lipoprotein (LDL) size and systemic factors, including glucose intolerance, oxidative stress, and inflammation, must be taken into account as c...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Badiou S,Perez V,Dupuy AM,Deswarte G,Frapier JM,Albat B,Cristol JP

    更新日期:2005-07-01 00:00:00

  • Membranous glomerulonephritis may be associated with heavy marijuana abuse.

    abstract::It is well documented that drug abuse can cause renal diseases. Nephropathy and proteinuria among heroin addicts has been recognized since the early 1970s. The predominant lesions in heroin-associated nephropathy are segmental glomerulosclerosis in African-Americans and membranous glomerulonephritis (MGN) in the Cauca...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bohatyrewicz M,Urasinska E,Rozanski J,Ciechanowski K

    更新日期:2007-12-01 00:00:00

  • Pulmonary hypertension is closely related to arterial stiffness in renal transplant patients.

    abstract:INTRODUCTION AND AIMS:Pulmonary hypertension (PH) is an independent predictor of increased mortality in patients on dialysis and those undergoing renal transplantation. We investigated PH and its association with vascular calcification and endothelial dysfunction in renal transplant patients. METHODS:The records of 30...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bal Z,Sezer S,Uyar ME,Bal U,Kulah E,Guliyev O,Tutal E,Haberal M

    更新日期:2015-05-01 00:00:00

  • Impact of valganciclovir on Epstein-Barr Virus polymerase chain reaction in pediatric liver transplantation: preliminary report.

    abstract:UNLABELLED:Preemptive therapy with ganciclovir has been recommended in the pediatric liver transplant strategy to avoid the development of posttransplant lymphoproliferative disorder (PTLD) from an high Epstein-Barr virus (EBV) is detected. We sought viral load to analyze the response to preemptive therapy with valganc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Venturi C,Bueno J,Gavalda J,Tórtola T,Pou L,Medina A,Codina G,Charco R,Pahissa A

    更新日期:2009-04-01 00:00:00

  • Living donor transplant: wider selection criteria.

    abstract::The availability of cadaveric donor organs is insufficient for actual needs. The organ demand increases by 20% per year. Living donor transplant (LDT) may be a valid therapeutical alternative provided one uses proper criteria. LDT provides many advantages, like improved patient and organ survival, short waiting time, ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Splendiani G,Cipriani S,Valeri M,Torlone N,Vega A,Tullio T,Condò S,Dominijanni S,Casciani CU

    更新日期:2004-04-01 00:00:00

  • Bench surgery with renal autotransplantation for angiomyolipoma of renal sinus.

    abstract:BACKGROUND:The treatment of angiomyolipomas (AML) of the renal sinus is challenging and often requires nephrectomy. In this study, we report on 5 patients who underwent extracorporeal AML resection and subsequent renal autotransplantation (RA) for renal sinus AML. METHODS:As of May 2013, 5 patients had undergone extra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zheng J,Zhou Z,Chen Z,Fang Q,Liu H,Zhu F,Pan J

    更新日期:2014-06-01 00:00:00

  • Liver transplantation for Wilson's disease in pediatric patients: decision making and timing.

    abstract::Transplantation for Wilson's disease occupies 1/3 of the cases for metabolic diseases in Japan. At the end of 2009, 109 transplantations had been performed including three deceased donor cases in the Japanese registry. We herein discuss problems of transplantation for Wilson's disease as well as its indication, timing...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Narumi S,Umehara M,Toyoki Y,Ishido K,Kudo D,Kimura N,Kobayashi T,Sugai M,Hakamada K

    更新日期:2012-03-01 00:00:00

  • The prevalence of C4d-positive renal allografts in 134 consecutive biopsies in Thai patients.

    abstract::Antibody-mediated rejection (AMR) has been recognized recently as an important cause of graft failure. Detection of C4d in renal allograft biopsies is a proven ancillary technique in the diagnosis of AMR. The prevalence of C4d staining in Western countries varies from 17% to 60% among indication biopsies. There are on...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cheunsuchon B,Vongwiwatana A,Premasathian N,Shayakul C,Parichatikanond P

    更新日期:2009-11-01 00:00:00

  • How reconstructive transplantation is different from organ transplantation--and how it is not.

    abstract::An evolution of understanding and knowledge gained over more than 100 years in the field of solid organ transplantation (SOT) led to the first successful clinical cases of composite tissue allotransplantation. In many ways reconstructive transplantation (RT) is similar to SOT; however, certain characteristics make thi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Hautz T,Brandacher G,Engelhardt TO,Pierer G,Lee WP,Pratschke J,Schneeberger S

    更新日期:2011-11-01 00:00:00

  • Perioperative considerations in HIV-infected liver transplanted patients.

    abstract:UNLABELLED:The introduction of highly active antiretroviral therapy (HAART) has improved survival in HIV patients, allowing them to undergo liver transplantation (OLT) in cases of end-stage liver disease. HIV patients show a higher incidence of pulmonary hypertension. The aim of this study was to evaluate pulmonary and...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Costa MG,Pompei L,Chiarandini P,Lugano M,Baccarani U,Tavio M,Della Rocca G

    更新日期:2009-05-01 00:00:00

  • A laparoscopic approach to allograft nephrectomy and bilateral native nephrectomy: a case report.

    abstract:INTRODUCTION:Laparoscopic surgery is rapidly emerging as the standard of care for a variety of urological conditions, even among patients who have undergone prior renal transplantation. We describe the technique of bilateral native nephrectomy and allograft nephrectomy by laparoscopy. CASE REPORT:A 32-year-old man wit...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Branco AW,Filho AJ,Kondo W,De George MA,Rangel M,De Carvalho RM,Noda RW

    更新日期:2005-06-01 00:00:00

  • Hepatitis C virus recurrence after liver transplantation: influence of immunosuppressive regimens on viral load and liver histology.

    abstract::Cyclosporine has recently been reported to produce in vitro suppression of hepatitis C virus replication driven by blockade of cyclophilins, an effect not shown for tacrolimus. However, the clinical consequence of this in vitro finding have not been well studied in vivo. We compared viral load and fibrosis in transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Oton E,Barcena R,Castillo M,Barreales M,Blesa C,Moreno-Planas JM,Barrios C,Garrido A,Cuervas V

    更新日期:2006-10-01 00:00:00

  • Living donor liver transplantation for Dorfman-Chanarin syndrome with 1 year follow-up: case report.

    abstract::A 27-year-old Japanese man underwent liver transplantation because of uncompensated cirrhosis due to Dorfman-Chanarin syndrome (DCS). At birth, the patient displayed ichthyosis and liver dysfunction. Moreover, mental retardation appeared and intracytoplasmic vacuoles were observed within peripheral blood neutrophils. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Takeda K,Tanaka K,Kumamoto T,Morioka D,Endo I,Togo S,Shimada H

    更新日期:2010-11-01 00:00:00

  • Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:--a case report.

    abstract:UNLABELLED:We generated an human embryonic stem cell (hESC) line to augment chimerism-associated tolerance. A 40-year-old African with chronic glomerulonephritis-chronic renal failure with 100% G6PD enzyme deficiency presented for renal transplantation with a 27-year-old, 6/6 HLA-matched sister as a willing donor. MET...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Trivedi HL,Mishra VV,Vanikar AV,Modi PR,Shah VR,Shah PR,Firoz A

    更新日期:2006-11-01 00:00:00

  • Anxiety and depression levels of patients undergoing liver transplantation and their need for training.

    abstract::The purpose of this research was to determine the levels of anxiety and depression and the need for training of patients who had undergone liver transplantation. This descriptive research included patients who had undergone liver transplantation at least 1 month prior and had follow-up between June and November 2006. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pelgur H,Atak N,Kose K

    更新日期:2009-06-01 00:00:00

  • Influence of body mass index in the postoperative evolution after lung transplantation.

    abstract:OBJECTIVE:To study the influence of body mass index (BMI) on mortality and postoperative evolution in our 10-year experience as a lung transplant group. METHODS:The study included 256 lung transplants performed between June 1999 and June 2009. BMI was stratified into 4 groups (<20 kg/m2 underweight, 20-25 normal weigh...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: de la Torre MM,Delgado M,Paradela M,González D,Fernández R,García JA,Fieira E,Borro JM

    更新日期:2010-10-01 00:00:00

  • Association of topical amphotericin B lipid complex treatment to standard therapy for rhinomaxillary mucormycosis after liver transplantation: a case report.

    abstract::Solid organ transplantation is becoming increasingly more common in the treatment of end-stage organ failure. The advent of newer immunosuppressive protocols and refined surgical techniques has allowed therapy to become standard care. Infection is a major and frequently life-threatening complication after transplantat...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Trasmonte MV,Jiménez JD,Santiago MÁ,Gálvez E,Jerez V,Pérez D,Robles M,Farje VK,Martínez P,Nieto P,Rubio JA

    更新日期:2012-09-01 00:00:00

  • Cardiovascular and Neurologic Complications in Kidney Transplant Recipients: A Focused Appraisal of Symptoms.

    abstract:BACKGROUND AND OBJECTIVE:After a kidney transplantation, all efforts are focused on graft function. However, cardiovascular and neurologic complications might lead to decreased quality of life and shortened life expectancy. Early recognition of related symptoms might be critical to successfully manage these complicatio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dogan U,Yaprak M,Dogan EA,Onac M,Yılmaz VT,Aydinli B

    更新日期:2019-05-01 00:00:00