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Altered expression of hepatocyte growth factor in cardiac allografts of nonhuman primates.

Abstract：

:Hepatocyte growth factor (HGF) plays a critical role in transplant rejection. Herein we addressed whether HGF expression could be used for accurate and early diagnosis of acute and chronic rejection in cardiac transplantation. We used a heterotopic cardiac transplantation model using nonhuman primates (Macaca fuscata, n = 7). The grafts were harvested on days 1, 7, 22, 28, 40, 41, and 95 for histology and immunohistochemistry. Histopathologically, HGF was expressed in the spindle-shaped cells of the acutely rejecting myocardium. The expression of HGF was enhanced in both thickened intima and media of the coronary arteries. Altered HGF expression is a sensitive indicator for acute and chronic cardiac rejection.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Suzuki J,Kawauchi M,Ogawa M,Isobe M

doi

10.1016/j.transproceed.2006.10.075

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

3318-20

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)01304-2

journal_volume

38

pub_type

杂志文章

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