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Utility of Oral Anticoagulants as Prophylaxis of Recurrent Portal Thrombosis after Liver Transplantation.

Abstract：

INTRODUCTION:Portal vein thrombosis (PVT) is a relatively common finding in patients undergoing liver transplantation. Although the recommendation to prevent its recurrence is anticoagulation for a duration of 3 to 6 months, this is controversial. AIM:The aim of our study was to determine the efficacy of oral anticoagulants (OAC) as prophylaxis for recurrent PVT after liver transplantation. MATERIALS AND METHODS:Our study included 215 liver transplant patients who underwent surgery in our center from January 2012 to August 2017. We selected all patients diagnosed with PVT either pre-transplantation (using Doppler echography or Angio-CT) or during transplant surgery. All patients with PVT were initially anticoagulated with low-molecular-weight heparin in the postoperative period; at discharge they received OAC for a duration of six months. Control Doppler ultrasound was performed at 3, 6, and 12 months post-transplantation. RESULTS:PVT was identified in 37 out of 215 patients (17.2%). PVT was diagnosed with a pre-transplant vascular study in 17 out of 37 cases (45.9%). All patients were anticoagulated with OAC (warfarin) for at least 6 months. There were no cases of recurrent thrombosis and no complications associated with anticoagulant treatment throughout the follow-up period. CONCLUSIONS:The prevalence of portal thrombosis in liver transplant patients in our study was fairly high, at 17.2%. PVT was identified in nearly 50% of patients using high-quality vascular studies prior to transplant surgery. Anticoagulation with OAC for 6 months was effective in preventing a recurrence of thrombosis and there were no associated complications.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sanchez-Ocaña R,Tejedor-Tejada J,Cimavilla-Roman M,de Benito-Sanz M,Asensio-Diaz E,Barrera-Rebollo A,Perez-Saborido B,Garcia-Pajares F,Almohalla-Alvarez C,Sanchez-Antolin G

doi

10.1016/j.transproceed.2018.07.014

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

83-86

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30940-0

journal_volume

51

pub_type

杂志文章

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