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Update on preclinical and clinical experience with mycophenolate mofetil.

Abstract：

:As initially predicted by in vitro and animal model experiments, MMF appears to demonstrate significant potential as a new immunosuppressive drug. Early clinical trials have shown that MMF can be used effectively to prevent allograft rejection, and to treat allograft rejection, in heart, liver, and kidney transplant patients. MMF may also help alleviate allograft arteriosclerosis associated with chronic allograft rejection. Three advanced, multicenter, international phase III trials have now shown that MMF at dosages of 2 g/d or 3 g/d improved immunosuppression in renal allografts when compared with either placebo or azathioprine. Our own experience in one of these trials demonstrated that ATGAM induction therapy, followed by a maintenance triple therapy of corticosteroids, cyclosporine, and MMF, is a safe, effective, and well-tolerated regimen for the prophylaxis of acute renal allograft rejection.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sollinger HW

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

24-9

issue

6 Suppl 1

eissn

0041-1345

issn

1873-2623

journal_volume

28

pub_type

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