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De novo tumors after kidney transplantation: the Budapest experience.

Abstract：

:In a retrospective study we analyzed the incidence and characteristics of de novo tumors developing in renal transplant recipients treated in our center. The 5% incidence de novo tumors developing among patients treated with azathioprine and prednisolone (n = 241) was similar to the 5.4% incidence of de novo tumors developing among patients treated with calcineurin-based immunosuppression (n = 1918). The most common malignancies among our patients were basal cell (21.7%) and squamous cell (13.9%) carcinomas of the skin, followed by urogenital (10.4%) and lung malformations (9.6%). A high incidence of Kaposi's sarcoma (9.6%; half cutaneous and half visceral) and a lower than expected incidence of posttransplant lymphoproliferative disorder (PTLD; 3.5%) was found. Among patients developing de novo tumors, the incidence of death with a functioning graft was higher than among recipients without tumors. Moreover, the incidence of tumor-related death was high among the de novo tumor recipients. Among our recipients, the most aggressive tumors were Kaposi's sarcoma, lung tumors, lymphomas, and gastrointestinal tumors, which occurred relatively early after transplantation and were the cause of death in most cases. Compared to tumor registry data, we found an inverse basal-to-squamous cell carcinoma ratio, a lower incidence of PTLD, and a higher incidence of Kaposi's sarcoma.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Langer RM,Járay J,Tóth A,Hídvégi M,Végsö G,Perner F

doi

10.1016/s0041-1345(03)00472-x

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

1396-8

issue

4

eissn

0041-1345

issn

1873-2623

pii

S004113450300472X

journal_volume

35

pub_type

杂志文章

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