Outcome of TiNi stent treatments in symptomatic central airway stenoses caused by Aspergillus fumigatus infections after lung transplantation.

Abstract:

BACKGROUND:Central airway stenoses due to Aspergillus fumigatus infections have been a significant cause of morbidity and mortality after lung transplantation. We reviewed our experience using self-expandable braided TiNi-metallic stents in the management of 4 single-lung transplant recipients with central airways stenoses between January 2003 and June 2010. METHODS:Thirty-six single-lung transplant recipients were subjected to pulmonary function testing and surveillance bronchoscopy with biopsy at predetermined intervals and when clinically indicated. Bronchial wash fluid and biopsy material were examined by appropriate fungal stain and culture techniques. RESULTS:Nine of 36 patients (25%) were diagnosed with Aspergillus fumigatus infections; 4 (11.1%) showed rapid decrease in pulmonary function and developed severe upper airway narrowings with about 80% of the central airway obstructed by thick plugs of mucus, heavily laden with Aspergillus species. All 4 patients were managed with stent placement as well as antifungal treatments and showed a forced vital capacity and forced expiratory volume in 1 second improvement of 11.3% and 25.9%, respectively after 1 month. CONCLUSIONS:TiNi stent applications in combination with antifungal drugs are sufficient to treat central airway stenoses after lung transplantation.

journal_name

Transplant Proc

authors

Xie BX,Zhu YM,Chen C,Zhao DP,Yang CL,Ding JA,Jiang GN

doi

10.1016/j.transproceed.2013.02.129

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2366-70

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00511-3

journal_volume

45

pub_type

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