当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST database.

Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST database.

Abstract：

INTRODUCTION:Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results. METHODS:The MOST database of "de novo" patients treated with MMF at month 1 and functioning grafts at month 12 were divided into 2 groups: groups 1, 2 g MMF at month 1 and month 12; and group 2, 2 g MMF at month 1 but MMF <2 g at month 12 to evaluate renal function glonerular filtration rate (GFR). RESULTS:In this study, 1136 patients were receiving 2 g MMF at month 1. On month 12, 645 were on 2 g (56.8%, group 1) and 431 were on <2 g (43.2%, group 2). Group 1 included younger recipients of younger donors with fewer patients with delayed graft function (DGF). Group 1 showed more ARE during month 1 and more patients who received induction. Mean Neoral daily doses at month 1/month 12 were 5.3/3.0 and 5.3/3.1 mg/kg in group 1 and group 2, respectively (P = .05 at month 12). GFR in group 1 and group 2 were 59.06 (CI 57.10-60.60) and 53.81 (CI 52-55.7) at month 1 (P < .001); 63.7 (CI 62.1-65.30) and 55.9 (CI 54.1-57.7) mL/min*1.73 m(2) at month 12 (P < .001). The mean increases in GFR between month 1 and month 12 were 4.64 and 1.94 mL/min*1.73 m(2), respectively (P < .05). A multivariate analysis also included 795 patients from the "maintenance" patient database with retrospective detailed information. The following parameters were highly predictive for good renal function at month 12: donor age younger than 60 years, recipient age younger than 60 years, immediate graft function, 12-month MMF dose = 2 g, absence of CMV infection, and 12-month Neoral dose <3 mg/kg/d. CONCLUSIONS:Maintenance of MMF dose at 2 g/d during the first year appears to facilitate the attainment of optimal renal function at 12-months after kidney transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Salvadori M,Bock A,Chapman J,Dussol B,Fritsche L,Kliem V,Lebranchu Y,Oppenheimer F,Pohanka E,Tufveson G,Rosati A,Puig X,Corbetta G,MOST International Study Group.

doi

10.1016/j.transproceed.2005.06.053

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

2464-6

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00689-5

journal_volume

37

pub_type

杂志文章,多中心研究

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Fluctuations of exercise capacity in patients after kidney transplantation.

    abstract：INTRODUCTION:The aim of this study was to assess changes in the exercise capacity in subjects with end-stage renal failure undergoing kidney transplantation. MATERIALS AND METHODS:The study group consisted of 16 subjects (9 males and 7 females) of mean age 43.3 +/- 11 years. The control group was composed of 7 healthy...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.10.071

    authors： Zakliczynski M,Spiechowicz U,Krynicka A,Trybunia D,Pyka L,Wiecek A,Zembala M

    更新日期：2009-01-01 00:00:00

  • Small bowel and colon transplantation in rats using porto-portal cuff anastomosis.

    abstract：:Portal versus systemic venous drainage and colon grafting are major controversies in the techniques of intestinal transplantation. The rat is the best animal for research in this field. Nevertheless, this model requires complex microvascular anastomoses that are responsible for the high incidence of technical failures...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.05.062

    authors： Galvão FH,Santos RM,Neto AB,Machado MA,Bacchella T,Machado MC

    更新日期：2006-07-01 00:00:00

  • Late spontaneous kidney graft decapsulation after administration of sirolimus in a recipient with chronic hepatitis B and C infection: a case report.

    abstract：:Late spontaneous kidney graft decapsulation with fluid collection is a rare condition with only a few cases reported in the literature. Common causes of renal allograft rupture include acute rejection, acute tubular necrosis, renal vein thrombosis, and trauma. Sirolimus related late spontaneous decapsulation has not b...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.07.044

    authors： Yang MH,Loong CC,Wu CW,Lui WY

    更新日期：2008-09-01 00:00:00

  • Brain death after severe traumatic brain injury: the role of systemic secondary brain insults.

    abstract：:Secondary brain insults predominantly due to hypotension are frequent among patients with fatal traumatic brain injury. We assessed the correlation between different systemic secondary brain insults and brain death in 404 patients admitted to our intensive care unit (ICU) after severe traumatic brain injury. We collat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.03.048

    authors： Sánchez-Olmedo JI,Flores-Cordero JM,Rincón-Ferrari MD,Pérez-Alé M,Muñoz-Sánchez MA,Domínguez-Roldán JM,Murillo-Cabezas F

    更新日期：2005-06-01 00:00:00

  • Liver transplantation in patients with hepatocellular carcinoma: one center's experience.

    abstract：:Hepatocellular carcinoma (HCC), which worldwide is the fifth most common malignancy in men and the ninth most common malignancy in women, accounts for 6% of all malignant lesions. We evaluated our results of liver transplantation for patients with HCC. Between January 2004 and April 2007, 31 patients (5 females, 26 ma...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.11.006

    authors： Karakayali H,Sevmis S,Moray G,Yilmaz U,Ozcay F,Savas NA,Arslan G,Haberal M

    更新日期：2008-01-01 00:00:00

  • Impact of live donor age (>or=50) on liver transplantation.

    abstract：BACKGROUND:The question of whether donor age negatively impacts recipient outcome in adult-to-adult living donor liver transplantation (LDLT) is rarely discussed. The aim of this study was to evaluate the impact of older donor age (50 years or older) on recipient outcomes in adult-to-adult LDLT. METHODS:LDLT data were...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.116

    authors： Akamatsu N,Sugawara Y,Tamura S,Kaneko J,Matsui Y,Togashi J,Makuuchi M

    更新日期：2007-12-01 00:00:00

  • Postoperative Myocardial Injury Does Not Predict Early and 1-Year Mortality After Living Donor Liver Transplantation.

    abstract：BACKGROUND:Preoperative cardiac troponin-I (cTnI) elevation has been shown to be a predictor of mortality after liver transplantation. Myocardial injury after non-cardiac surgery (MINS) has been defined as elevation of serum cardiac troponin levels in the perioperative period that does not fulfill the criteria for myoc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.02.046

    authors： Canbolat IP,Adali G,Akdeniz CS,Bozkurt B,Ferah O,Bulutcu F,Yuzer Y,Tokat Y

    更新日期：2019-09-01 00:00:00

  • Pancreas islet transplantation in the genitourinary tract associated with renal transplantation: an experimental study.

    abstract：:Conceptually, pancreas islet transplantation (PIT) associated with renal transplantation (RT) should resolve not only chronic renal failure but also diabetes. Although the most frequently used site for PIT is the portal vein, genitourinary locations could be technically feasible during RT. Seventeen pigs (age 3 to 4 m...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.068

    authors： Burgos FJ,Gómez V,Pascual J,Marcen R,Villafruela JJ,Correa C,Cuevas B,Mampaso F,García-Gonzalez R

    更新日期：2006-10-01 00:00:00

  • Microwave thermal ablation for hepatocarcinoma: six liver transplantation cases.

    abstract：:Surgical resection for malignant hepatic tumors, especially hepatocarcinoma (HCC), has been demonstrated to increase overall survival; however, the majority of patients are not suitable for resection. Radiofrequency ablation (RFA) is the most widely used modality for radical treatment of small HCC (<3 cm). It improves...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.02.044

    authors： Zanus G,Boetto R,Gringeri E,Vitale A,D'Amico F,Carraro A,Bassi D,Bonsignore P,Noaro G,Mescoli C,Rugge M,Angeli P,Senzolo M,Burra P,Feltracco P,Cillo U

    更新日期：2011-05-01 00:00:00

  • Switch to everolimus for sirolimus-induced pneumonitis in a liver transplant recipient--not all proliferation signal inhibitors are the same: a case report.

    abstract：:We report a 62-year-old female liver transplant patient who presented with sirolimus (SIR)-related pneumonitis (SIP) treated with a switch to everolimus (EVER). At 13-month follow-up, the patient is on EVER monotherapy with no recurrence of SIP. Despite common mechanisms of action, the safety profile of EVER is differ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.09.040

    authors： De Simone P,Petruccelli S,Precisi A,Carrai P,Doria R,Menichetti F,Filipponi F

    更新日期：2007-12-01 00:00:00

  • Activity of the National Polish Bone Marrow Donor Registry--analysis of the matching process successfully completed with hematopoietic stem cell transplantation.

    abstract：:The activity of the National Polish Bone Marrow Donor Registry includes: (1) recruitment and typing of volunteer donors for the registry; (2) primary and confirmatory typing of patients and their families for sibling and family alternative donor transplantations; and (3) donor-recipient matching. There has been an imp...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.09.001

    authors： Lange A,Dera-Joachimiak D,Madej S,Polak M,Koscinska K,Pietraszek E,Skurjat L

    更新日期：2010-10-01 00:00:00

  • Structural and Functional Adaptation of the Remnant Kidney After Living Kidney Donation: Long-Term Follow-up.

    abstract：OBJECTIVE:Several adjustments occur after nephrectomy (NT) in the donor's remnant kidney. We investigated kidney donors 10 years after NT and compared several parameters before and after transplantation. METHODS:A total of 42 kidney donors of the University of Luebeck's Transplant Center were scheduled for a 10-year f...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.07.007

    authors： Meier M,Winterhoff J,Fricke L,Lehnert H,Nitschke M

    更新日期：2017-11-01 00:00:00

  • A comparative study of the traditional method, and a point-score system for allocation of deceased-donor kidneys: a national multicenter study in Mexico.

    abstract：BACKGROUND:The National Transplant Center in Mexico has ruled that deceased-donor kidney allocation is a function of each hospital's Internal Transplant Committee. The aim of this study was to compare and analyze results for of the traditional method and a point-score system in the allocation of deceased patient's kidn...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2011.09.091

    authors： Cantú-Quintanilla G,Alberú J,Reyes-Acevedo R,Medeiros M,Villa MS,Arreola JM,Gracida C,Reyes-López A

    更新日期：2011-11-01 00:00:00

  • The effect of tezosentan after cold ischemia and renal artery clamping as a model of reperfusion injury in newborn piglets.

    abstract：BACKGROUND:Cold ischemia and clamping of the renal artery contribute to acute tubular necrosis and renal dysfunction of transplant grafts. The mechanism of ischemic injury is not fully understood, but endothelin (ET)-1 and -2 have been found to participate in reperfusion injury. ET receptor blockade has been shown to h...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.02.071

    authors： Pham J,Beier UH,Fornell L,Chin A,Samuel S,Radhakrishnan J,John E

    更新日期：2008-06-01 00:00:00

  • High incidence of malignancy in polyomavirus-associated nephropathy in renal transplant recipients.

    abstract：:Human polyomaviruses (PV), including JC and BK virus, have been reported to cause polyomavirus-associated nephropathy (PVAN), in renal transplant patients. PV infection has been demonstrated to be associated with malignancies in animals; however, the association between malignancy and viral infections in humans is not...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.068

    authors： Chen CH,Wen MC,Wang M,Lian JD,Cheng CH,Wu MJ,Yu TM,Chuang YW,Chang D,Shu KH

    更新日期：2010-04-01 00:00:00

  • Investigation of the Causes and Risk Factors of Previous End-Stage Renal Disease in Kidney Transplant Recipients.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is a pathophysiological process with many etiologic causes, often leading to end-stage renal disease (ESRD). The distribution of the causes that lead to ESRD varies by country, race, and sex. Renal failure may be prevented by determining these differences and reducing the risk fa...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.11.019

    authors： Aksoy N,Şelimen D

    更新日期：2020-01-01 00:00:00

  • Antibody-mediated response in rat liver chronic rejection.

    abstract：PURPOSE:The aim was to study the effect of an antibody-mediated response on rat chronic liver rejection. METHODS:Liver transplantation was performed in rats assigned to one of the 3 treatment groups: group A, Brown Norway (BN) to BN + CsA; group B, dark Agouti (DA) to BN; and group C, DA to BN + CsA. In addition to su...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.03.043

    authors： Wan R,Ying W,Zeng L,Deng X,Chen H,Gao L

    更新日期：2011-06-01 00:00:00

  • Information channels and the dynamics of uptake of living kidney donors: a retrospective study in a reference area.

    abstract：INTRODUCTION:Activity in renal transplantation at our center continues to grow due to the gradual increase in living donor kidney transplantations (LDKT). Our objective was to describe the generation process of living donation in our area of influence including two provinces and 18 chronic kidney disease (CKD) treatmen...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.05.004

    authors： Vidal Blandino M,Gentil Govantes MA,Cabello Chaves V,Pereira Palomo P,Bernal Blanco G,Gonzalez Roncero FM,Fijo Viota J,Medina López R

    更新日期：2011-07-01 00:00:00

  • Evaluation of research products released during a national project funded by the Italian Ministry of Health.

    abstract：:Evaluation of research products released during activities that have received public funds should be a mandatory practice. In this study, we evaluated the research products released during the research program "Innovative Strategies to Expand Cadaveric Donor Pool for Liver Transplantation" (SITF Project), funded by th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.05.017

    authors： Santori G,Valente R,Ghirelli R,Valente U

    更新日期：2008-07-01 00:00:00

  • Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis.

    abstract：INTRODUCTION:The preoperative elevation of ammonia may be associated with postoperative neurologic complications. The aim of this study was to evaluate the effect of preoperative ammonia level on the incidence of delirium in patients after liver transplantation (LT). MATERIALS AND METHODS:Patients (n = 260) who receiv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.11.012

    authors： Ri HS,Choi YJ,Park JY,Jin SJ,Lee YS,Son JM,Yoon SZ,Shin HW,Choi BH,Lee TB

    更新日期：2020-01-01 00:00:00

  • Preliminary analysis of factors influencing organ donation rates in China.

    abstract：:In recent years, the People's Republic of China has experienced advancements in organ transplant surgical techniques, growing transplant waiting lists, and stagnant organ donation rates. All of these factors have pressured China to find ways to increase brain-dead cadaveric donation rates to narrow the gap between org...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.01.166

    authors： Zhang L,Wang J,Kwauk S,Wu Q,Nielson K,Zeng F,Bai M,Wang C

    更新日期：2011-06-01 00:00:00

  • The family interview in the process of donating organs and tissues for transplantation: perceptions of potential donors' relatives.

    abstract：BACKGROUND:The family interview is a complex phase of the organ donation process because it involves aspects of the interviewer, the interviewee, the interview location, and ethical and legal issues. However, there are few publications on this phase of the donation process. This study aimed to reveal the meaning assign...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.05.010

    authors： dos Santos MJ,Massarollo MC,de Moraes EL

    更新日期：2014-07-01 00:00:00

  • De novo tumors after kidney transplantation: the Budapest experience.

    abstract：:In a retrospective study we analyzed the incidence and characteristics of de novo tumors developing in renal transplant recipients treated in our center. The 5% incidence de novo tumors developing among patients treated with azathioprine and prednisolone (n = 241) was similar to the 5.4% incidence of de novo tumors de...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00472-x

    authors： Langer RM,Járay J,Tóth A,Hídvégi M,Végsö G,Perner F

    更新日期：2003-06-01 00:00:00

  • Graft survival with high levels of cytotoxic antibodies.

    abstract：:In this study, pretransplant transfusions significantly improved the survival of first cadaver kidney transplants. Large numbers of transfusions had the same influence on graft survival as small number of transfusions. Graft survival was not influenced by pretransplant antibody levels, and the beneficial effect of tra...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Feduska NJ,Amend WJ,Vincenti F,Perkins HA,Opelz G,Terasaki PI,Iwaki Y,Duca R,Dodge D,Salvatierra O

    更新日期：1981-03-01 00:00:00

  • Heart rate variability during hemodialysis and following renal transplantation.

    abstract：:Previous studies have shown awareness of uremic dysfunction in end-stage renal disease (ESRD) patients. Dysautonomia in ESRD patients may be reversible after renal transplantation. We used a power spectral analysis (PSA) of heart rate variability (HRV) to assess alterations of autonomic activity in 14 controls and 14 ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.01.062

    authors： Yang YW,Wu CH,Tsai MK,Kuo TB,Yang CC,Lee PH

    更新日期：2010-06-01 00:00:00

  • Liver Allocation in Urgent MELD Score ≥30: The Italian Experience.

    abstract：INTRODUCTION:Patients with an urgent MELD score ≥30 are managed by the Italian Operative National Transplant Center on the basis of a division of Italy into 2 main areas, the northern macro area (NMA) and the southern macro area (SMA). The object of this study was to evaluate the possibility and the need to transform t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.047

    authors： Trapani S,Morabito V,Oliveti A,Peritore D,Rizzo A,Cacciotti AR,Gaeta A,Montemurro A,Rizzato L,Nanni Costa A

    更新日期：2016-03-01 00:00:00

  • Outcomes of simultaneous kidney-pancreas transplantation with positive cross-match.

    abstract：:We studied 72 consecutive simultaneous pancreas kidney transplant (SPKT) recipients. There were 14 patients with positive pretransplant cross-matches (positive CDC- B cell and/or positive flow T or B cross-match). The control group included all 58 SPKT recipients with a negative crossmatch. The study group received in...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.154

    authors： Heilman RL,Chakkera H,Mazur M,Petrides S,Moss A,Mekeel K,Mulligan D,Reddy KS

    更新日期：2009-01-01 00:00:00

  • Does etiology of end-stage renal disease affect sleep quality in kidney transplant recipients?

    abstract：BACKGROUND:That hypertension (HTN) as a leading cause of end-stage renal disease (ESRD) is linked to sleep disorders in the general population can be the basis of a hypothesis that HTN may be a contributing factor to the poor quality of sleep in some kidney transplant recipients. This study was designed to investigate ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.011

    authors： Ameli J,Kachuee H,Assari S,Rasta VR,Khoddami-Vishte HR,Einollahi B,Lessan-Pezeshki M,Khedmat H

    更新日期：2007-05-01 00:00:00

  • Transplant tourism and donor-derived parasitic infections.

    abstract：:Transplant tourism, travel with the intent of receiving or donating a transplanted organ, has grown immensely in the past decade but is not without risks. Solid organ donors are potential carriers of infection and rates of infection are high in transplant recipients. Returning transplant recipients should be screened ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2011.06.022

    authors： Kotton CN

    更新日期：2011-07-01 00:00:00

  • Complete regression of cutaneous B-cell lymphoma in a renal transplant patient after conversion from cyclosporin to sirolimus.

    abstract：:Posttransplant lymphoproliferative disease remains a serious morbidity. Herein we have reported a case of complete regression of a biopsy-proven B-cell lymphoma that occurred in the posttransplant period. A 48-year-old man received a living donor renal transplant for end-stage renal disease due to undetermined etiolog...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.092

    authors： Mohsin N,Budruddin M,Kamble P,Khalil M,Pakkyarra A,Jha A,Mohammed E,Ahmed H,Ahmed J,Thomas S,Campistol JM,Daar A

    更新日期：2007-05-01 00:00:00