Switch to everolimus for sirolimus-induced pneumonitis in a liver transplant recipient--not all proliferation signal inhibitors are the same: a case report.

Abstract:

:We report a 62-year-old female liver transplant patient who presented with sirolimus (SIR)-related pneumonitis (SIP) treated with a switch to everolimus (EVER). At 13-month follow-up, the patient is on EVER monotherapy with no recurrence of SIP. Despite common mechanisms of action, the safety profile of EVER is different from SIR, and a switch from SIR to EVER should be contemplated in cases of SIP to allow patients to benefit from the antifibrotic properties of antiproliferative immunosuppressants.

journal_name

Transplant Proc

authors

De Simone P,Petruccelli S,Precisi A,Carrai P,Doria R,Menichetti F,Filipponi F

doi

10.1016/j.transproceed.2007.09.040

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

3500-1

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)01275-4

journal_volume

39

pub_type

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