Abstract:
BACKGROUND:Obesity and disturbances of adipokine concentrations are often recognized in kidney transplant recipients (KTRs). Leptin plays a key role in regulating energy intake and expenditure, including appetite and hunger, metabolism, and behavior. Adiponectin modulates certain metabolic processes, including glucose regulation and fatty acid oxidation, and exerts some weight-reduction effects. Visfatin has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptors and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The aim of this study was to evaluate the prevalence of leptin, adiponectin, and visfatin and nutritional status abnormalities in stable KTRs. METHODS:Eighty KTRs aged 52.4 ± 14.0 years participated in the study. Nutritional status was determined with the use of the 7-point Subjective Global Assessment (SGA), anthropometric measurements (bioimpedance analysis), and serum concentration. Concentrations of leptin, adiponectin, and visfatin were measured with the use of enzyme-linked immunosorbent assay. RESULTS:Mean time after transplantation and estimated glomerular filtration rate (eGFR; Modification of Diet in Renal Disease formula) were 82.5 ± 56.5 months and 42.0 ± 15.0 mL/min/1.73 m(2), respectively; 29 (36.2%) of the KTRs, despite high body mass index (BMI ≥25 kg/m(2)), presented mild malnutrition (SGA ≤5). BMI, content of body fat, and leptin concentration correlated positively with time from transplantation and negatively with eGFR. Additionally, patients with BMI ≥25 kg/m(2) presented significantly higher leptin-to-adiponectin ratios compared with lean patients (3.5 vs 1.1, respectively; P < .05). KTRs with eGFR ≥60 mL/min/1.73 m(2) presented significantly lower leptin concentration and BMI. CONCLUSIONS:Despite high BMI, mild malnutrition was present in one-third of KTRs. Increased BMI, abdominal obesity, and high leptin concentration were aggravated by time from transplantation and deterioration of graft function. Overweight/obesity and incorrect leptin-to-adiponectin ratio could increase cardiovascular risk in KTRs.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Małgorzewicz S,Dębska-Slizień A,Czajka B,Rutkowski Bdoi
10.1016/j.transproceed.2014.09.014subject
Has Abstractpub_date
2014-10-01 00:00:00pages
2622-6issue
8eissn
0041-1345issn
1873-2623pii
S0041-1345(14)00800-8journal_volume
46pub_type
杂志文章abstract::Enteric-coated mycophenolate sodium (myfortic, Novartis Pharma AG, Basel, Switzerland) is designed to improve the gastrointestinal tolerability of micophenolic acid. This study was designed to evaluate the efficacy and safety of myfortic in Korean de novo renal transplantation. A total of 65 patients from four transpl...
journal_title:Transplantation proceedings
pub_type: 杂志文章,多中心研究
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abstract::Cardiovascular disease is a major cause of morbidity and mortality in children and young adults with end-stage renal disease. In our study, we retrospectively analyzed the records of 11 patients who had undergone electron beam computerized tomography in our dialysis unit. Our patients, aged 11 to 24 years (median, 19....
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abstract::Autoimmune-mediated cytotoxicity may cause pancreatic islet transplant failure, leading to recurrent diabetes. Protection of islet grafts depends on immunosuppressive control, which may also prevent autoimmune recurrence of diabetes. In this study, we compared the survival of syngeneic islet transplants using differen...
journal_title:Transplantation proceedings
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abstract::There is some evidence that portal venous drainage may offer immunologic and metabolic advantages in small bowel transplantation. Isolated small bowel transplantation was performed in 14 adult patients. In all cases, the donor pancreas was transplanted into another patient. During the donor procedure, the superior mes...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2003.12.018
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pub_type: 杂志文章,评审
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abstract::Thrombosis of the pancreatic graft vessels is the most common complication after transplantation. It leads to loss of 5% to 8% of grafts during the early postoperative period. The aims of this study were to evaluate the usefulness of 16-row multidetector computed tomography (16-MDCT) with volume rendering (VR) and max...
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journal_title:Transplantation proceedings
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doi:10.1016/j.transproceed.2014.05.010
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更新日期:2013-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2008.02.044
更新日期:2008-04-01 00:00:00
abstract::We admixed cultured porcine keratocytes or corneal endothelial cells in the presence of human sera or peripheral blood mononuclear cells (PBMCs) for 4 to 72 hours to investigate their immune-related susceptibilities to xeno-related rejection. We evaluated complement deposition at 48 hours by flow cytometry after stain...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.12.024
更新日期:2008-03-01 00:00:00
abstract::The shortage of available cadaveric organs for transplantation and the growing demand has incresed live donation. To increase the number of transplantations from living donors, programs have been implemented to coordinate donations in direct or indirect form (cross-over, paired, and domino chain). Living donors with c...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2013.07.026
更新日期:2013-09-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.06.065
更新日期:2009-07-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.transproceed.2018.09.003
更新日期:2018-12-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.06.186
更新日期:2009-11-01 00:00:00
abstract::The efficacy of bromocriptine, chloroquine, and Cs was quantitated in an in vitro system, with the use of mitogen-stimulated human PBMC. A concentration-dependent effect was found for each drug. Based on counts of blast cells, Cs was roughly 70 times more effective than either bromocriptine or chloroquine. Besides qua...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:AIMS:We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen. METHODS:Eight patients received 12 islet infusions in 5 IAK and 3 SIK procedures. Median age was 51 ye...
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pub_type: 杂志文章
doi:10.1016/j.transproceed.2004.04.027
更新日期:2004-05-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.05.006
更新日期:2007-07-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2005.03.144
更新日期:2005-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:In living donor liver transplantation (LDLT), a graft-to-recipient weight ratio (GRWR) of under 0.8 is recognized as the critical graft size. Our aim was to compare the survival rates of recipients with small-for-size grafts (SFSG: GRWR <0.8), normal-sized grafts (NSG), and large-for-size grafts (LFSG: GRWR ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::Proteinuria is an early finding that appears in the first 3 months after transplantation in half of patients. Frequently, it is very low grade (VLP; <0.5 g/24 h). The aim of this study was to analyze the risk factors and prognostic significance of VLP at 3 months posttransplantation, which was maintained for the first...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.06.137
更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.11.062
更新日期:2008-01-01 00:00:00
abstract::The success of human islet isolation is hampered by the varied and unpredictable outcomes of the islet isolation procedure. Pancreata which meet well-defined criteria are no guarantee for success. Interindividual variations may contribute to the differences in isolation outcomes. The present study examined several str...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.12.022
更新日期:2008-03-01 00:00:00