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Techniques to Ameliorate the Impact of Second Warm Ischemic Time on Kidney Transplantation Outcomes.

Abstract：

:Anastomosing the renal artery and vein in transplant recipients without a cooling mechanism exposes the kidney to temperatures exceeding the metabolic threshold (15°C to 18°C), at which the protective effects of renal hypothermia are lost. This anastomotic time, or second warm ischemic time, can be deleterious to graft outcomes, especially if it is prolonged. Techniques to ameliorate organ warming prior to reperfusion have been designed, and range from simpler surface cooling techniques, to organ immersion in bags of ice slush, and the application of 'jackets' that incorporate their own internal cooling mechanism. The efficacy of these methods with respect to the minimization of kidney temperature prior to reperfusion and subsequent effects on graft outcomes are discussed using clinical and experimental data, in the setting of open, laparoscopic, and robotic kidney transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hameed AM,Yuen L,Pang T,Rogers N,Hawthorne WJ,Pleass HC

doi

10.1016/j.transproceed.2018.09.003

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3144-3151

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30750-4

journal_volume

50

pub_type

杂志文章,评审

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