Abstract:
BACKGROUND:Kidney biopsy is an important tool in determining allograft suitability for transplantation. Most deceased-donor renal biopsies performed today in the United States are wedge biopsies (WBs), with core needle biopsies being performed only by a minority of organ procurement organizations (OPOs). The lack of a gold standard in tissue sampling and tissue evaluation has prompted our OPO to find a more sensitive biopsy method as well as a more accurate pathology evaluation protocol to reassess expanded-criteria donor kidneys. METHODS:Between the months of March 2007 and June 2008, the New York Organ Donor Network OPO imported 226 kidneys. These kidneys had been previously biopsied by the originating OPOs utilizing the WB method. All 226 kidneys were rebiopsied by our preservation team using the optimized needle biopsy technique (ONBT) and then evaluated by the pathologists of the Transplant Pathology Laboratory of the Mount Sinai Hospital. RESULTS:Histologic findings from both types of biopsies were compared in the following parameters: glomerular yield, percentage of obsolete glomeruli, tubular interstitial scarring, arterial intimal fibrosis and acute tubular necrosis. Difference in glomerular yield between WB and ONBT was not statistically significant (P = .1736). ONBT detected more tubular interstitial scarring and arterial intimal fibrous narrowing than WB (P = .00). No statistical difference was found between the two biopsy methods in identifying acute tubular necrosis. CONCLUSION:The data suggest that there were no statistical differences in sample reliability between ONBT and WB. However, ONBT was found to be significantly more sensitive in identifying allograft tubular interstitial scarring as well as intimal fibrous narrowing. Overall this study provides proof that ONBT is a more reliable and accurate method compared to WB in identifying important parameters of renal allograft.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Yushkov Y,Dikman S,Alvarez-Casas J,Giudice A,Hoffman A,Goldstein MJdoi
10.1016/j.transproceed.2010.04.058subject
Has Abstractpub_date
2010-09-01 00:00:00pages
2493-7issue
7eissn
0041-1345issn
1873-2623pii
S0041-1345(10)00945-0journal_volume
42pub_type
杂志文章abstract:BACKGROUND:The purpose of this study was to analyze the incidence, clinical characteristics, treatment, and outcome of upper aerodigestive (UAD) and lung de novo tumors after ortothopic liver transplantation (OLT). PATIENTS AND METHODS:Between April 1986 and June 2002, we performed 851 OLT in 753 patients. We excluded...
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journal_title:Transplantation proceedings
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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pub_type: 杂志文章
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abstract::The hemolytic uremic syndrome (HUS) is a severe disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. We herein report our experience with a 43-year-old female patient who underwent a second cadaveric kidney transplantation in February 2005, for adult-onset HUS. The fir...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2006.02.019
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2017.07.007
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.06.028
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2011.05.015
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2013.02.122
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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