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Evaluation of the equations to estimate the glomerular filtration rate in kidney transplant recipients.

Abstract：

:This study assessed the performance of three methods for estimating glomerular filtration rate (GFR) in kidney transplant patients: the Cockcroft-Gault formula, the modification of diet in renal disease (MDRD) method, and the four-variable modification of diet in renal disease (four-variable MDRD), both as an overall estimate and as related to clinical disease stage. We analyzed data from 136 renal transplant patients including 84 men in an overall age range of 28 to 76 years. Patients were categorized into three groups according to GFR as determined by the arithmetical mean of the last four creatinine clearance determinations after outlying values had been excluded: group 1, estimated GFR of <30 mL/min (n = 26); group 2, estimated GFR of 30 to 60 mL/min (n = 63);, and group 3, estimated GFR >60 mL/min (n = 33). Fourteen patients were excluded from the analysis because of a high variability between their creatinine clearance determinations. Estimated GFRs using the Cockroft-Gault, MDRD, and four-variable MDRD formulae were compared with GFRs as measured by creatinine clearance. Statistically significant correlations were observed for all three formulae for the overall series and for individual clinical groups. Hence, we concluded that all equations had a similar capacity to predict the GFR. In addition, because of the clear, significant correlation between the MDRD and the four-variable MDRD (r = .992; P = .0001), we believe that the four-variable MDRD can substitute for the MDRD for clinical purposes.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Estrada-Zambrano A,Biosca-Adzet C,Bayés-Genís B,Doladé-Botias M,Lauzurica-Valdemoros R,Romero-González R

doi

10.1016/j.transproceed.2007.06.028

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

2210-3

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)00745-2

journal_volume

39

pub_type

杂志文章

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