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Reliability of frozen section in the assessment of allograft steatosis in liver transplantation.

Abstract：

BACKGROUND:Because liver allograft steatosis is an important risk factor of graft dysfunction after liver transplantation, it must be taken into consideration during graft acceptance. The aim of this study was to evaluate the reliability of frozen section in the assessment of liver steatosis before transplantation. METHODS:The retrospective analysis was based on data of 112 liver allograft procurements performed between 2003 and 2012. Hepatic steatosis was assessed in frozen and routine sections. Sensitivity, specificity, and positive and negative predictive values of the frozen section were evaluated with respect to detection of >30% and >50% steatosis. RESULTS:According to routine section assessment, there were 32 (28.6%) cases of steatosis >30% and 16 (14.3%) of >50%. The results of frozen section assessment were underestimated and overestimated in a similar low number of cases, both for the >30% (0.0% and 0.9%, respectively, P < 1.000) and the >50% (4.5% and 0.9%, respectively, P = .221) cutoff. Sensitivity, specificity, positive and negative predictive values of frozen section assessment were 100.0%, 98.8%, 97.0%, and 100.0%, respectively, for detection of >30% steatosis, and 68.8%, 99.0%, 91.7%, and 95.0%, respectively, for >50% steatosis. CONCLUSIONS:Considering high positive predictive value of frozen section assessment in detection of >50% steatosis, it may serve as a base to discard the use of graft for transplantation. However, according to the relatively moderate sensitivity of this method, decision of graft acceptance must also be made on consideration of other well-known factors for poor posttransplant function.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hołówko W,Mazurkiewicz M,Grąt M,Koperski L,Lewandowski Z,Smoter P,Ziarkiewicz-Wróblewska B,Górnicka B,Zborowska H,Krawczyk M

doi

10.1016/j.transproceed.2014.09.102

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

2755-7

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00897-5

journal_volume

46

pub_type

杂志文章

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