当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Cytotoxic T Lymphocyte-associated Protein 4 Acts on Local Draining Lymph Nodes in the Allogeneic Abdominal Skin Flap of a Rat Model to Extend Its Survival.

Cytotoxic T Lymphocyte-associated Protein 4 Acts on Local Draining Lymph Nodes in the Allogeneic Abdominal Skin Flap of a Rat Model to Extend Its Survival.

Abstract：

BACKGROUND:Early acute allograft rejection is the result of immune cells mainly composed of thymocyte (T) cells, which are activated, mature, and differentiate in lymphoid tissue. METHODS:Cytotoxic T lymphocyte-associated protein 4 immunoglobulin (CTLA4-Ig) competitively suppresses the cluster of differentiation 28/CTLA4-B7 costimulatory signaling pathway and alters the ratio of T helper 1 to T helper 2, leading to the inhibition of T cell activation. RESULTS:We used lentivirus-packed CTLA4-Ig to infect the local draining lymph nodes of the allograft skin flap in a rat model, which effectively extended the survival of the allograft. Meanwhile, it also reduced the dose of immunosuppressant necessary in the early stages of transplantation, which lowered the toxicity and side effects of the drug. CONCLUSIONS:Our findings provide new insights into transplantation immunology, facilitate the exploration of a safe and effective immunosuppressive therapy, and promote the wide clinical application of composite tissue allotransplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Ma G,Pei J,Li Y,Han Y,Liu D

doi

10.1016/j.transproceed.2016.10.024

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

3415-3421

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(16)30779-5

journal_volume

48

pub_type

杂志文章

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