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Severe colchicine intoxication in a renal transplant recipient on cyclosporine.

Abstract：

:Using colchicine to treat an acute gout crisis in an organ transplant recipient (TR) on cyclosporine (CsA) may result in life-threatening intoxication. We report the case of a 59-year-old kidney transplant recipient on CsA who was treated with colchicine for acute gout crisis. Seven days later, he developed rhabdomyolysis with progressive quadriparesis, hematologic toxicity and acute renal failure. CsA inhibits P-glycoprotein resulting in decreased hepatic metabolism and renal excretion of colchicine. Colchicine and CsA withdrawal as well as appropriate supportive treatments were effective to manage all of these complications.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Garrouste C,Philipponnet C,Kaysi S,Enache I,Tiple A,Heng AE

doi

10.1016/j.transproceed.2012.09.028

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

2851-2

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(12)01009-3

journal_volume

44

pub_type

杂志文章

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