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Successful treatment of 115 pediatric renal transplant recipients with tacrolimus-based immunosuppressive therapy: a 7-year multicenter study in Japan.

Abstract：

:The safety and efficacy of tacrolimus (Tac)-based immunosuppressive treatments were studied in 115 pediatric renal transplant recipients (mean follow-up period, approximately 20 months). The acute rejection rate was 22.7% 6 months after transplantation and the steroid-resistant acute rejection rate was 6.4%. The 5-year patient and graft survival rates were 98.6% and 95.9%, respectively. Major adverse effects included infection, ie, cytomegalovirus (CMV) antigenemia (41.7%), renal dysfunction (29.6%), and impaired glucose tolerance (20.9%). The incidences of these adverse events were significantly decreased among patients who had undergone transplantation after March 2000 (n = 43), namely, 30.2%, 18.6%, and 11.6%, respectively.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hasegawa A,Oshima S,Takahashi K,Uchida K,Ito K,Sonoda T

doi

10.1016/j.transproceed.2005.03.071

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

1769-70

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00309-X

journal_volume

37

pub_type

杂志文章,多中心研究

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