当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Stable renal transplant recipients can be safely converted from MMF to enteric-coated mycophenolate sodium tablets: Interim results of a multicenter Latin American study.

Stable renal transplant recipients can be safely converted from MMF to enteric-coated mycophenolate sodium tablets: Interim results of a multicenter Latin American study.

Abstract：

:Enteric-coated mycophenolate sodium (EC-MPS) is designed to reduce mycophenolate acid (MPA)-related upper gastrointestinal (GI) adverse events (AEs). A multicenter, open-label, Latin American study in stable renal transplant patients is ongoing to assess the safety of the conversion from mycophenolate mofetil (MMF) to EC-MPS. An interim analysis was performed when 93 patients had completed 3 months. Prior to conversion, they had received MMF at a dose of 2 g/d, with the exception of eight adult patients who were receiving an average daily dose of 1.25 g. All adult patients were converted to EC-MPS (1.44 g/d; 0.450 g/m(2) bid for children). After conversion, the reported total incidence of AEs was 40.9%, including 28% infections, 1.1% hematologic, 19.4% GI, including 10.8% upper-GI AE (all mild) and 5.4% diarrhea. No patient discontinued the study medication due to adverse events. Only six patients (6%) required a dose adjustment. There were no episodes of acute rejection, death, or graft loss. During the period of analysis, the conversion from MMF to EC-MPS was safe, the enteric-coated tablet formulation prevented release of MPA in the upper GI tract, and only one patient had to reduce the dose due to an upper GI AE, concomitant with diarrhea. EC-MPS offers transplant physicians and their patients an alternative MPA therapy that is as effective and safe as MMF, but in a formulation that may provide GI tolerability benefits.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Abbud-Filho M,Girón F,Hernández E,Juarez F,Liendo C,Novoa P,Toledo M,Myproms Latam Study Group.

doi

10.1016/j.transproceed.2004.07.031

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

1647-9

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00813-9

journal_volume

36

pub_type

临床试验,杂志文章,多中心研究

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Dose/time-dependent modulation of the endothelial function through induction agents: non-depleting versus depleting agents.

    abstract：BACKGROUND:Polyclonal anti-thymocyte globulins (ATGs) and anti-CD25 antibodies are agents used for induction of immunosuppression in solid-organ transplantation. We aimed to investigate the effect of different regimens of these immunosuppressive induction agents on transendothelial migration of peripheral blood mononuc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.055

    authors： Werner I,Bogert NV,Stock UA,Moritz A,Beiras-Fernandez A

    更新日期：2014-11-01 00:00:00

  • Vaccination Against Urinary Tract Infection After Renal Transplantation.

    abstract：BACKGROUND:Recurrent urinary tract infections (UTIs) increase mortality and reduce graft survival after renal transplantation. Because current prophylactic strategies such as methionine, cranberry juice, and antibiotics fail to sufficiently prevent recurrent infections in a substantial number of patients, there is a cl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.018

    authors： Zgoura P,Waldecker C,Bauer F,Seibert FS,Rohn B,Schenker P,Wunsch A,Hajt S,Viebahn R,Babel N,Westhoff TH

    更新日期：2020-12-01 00:00:00

  • PTFE mesh in renal allograft compartment syndrome.

    abstract：:We report a case of anuria in a 42-year-old female kidney transplant patient that occurred secondary to extrinsic compression from a large kidney being placed extraperitoneally in a small iliac fossa. Prompt reexploration in the immediate postoperative period resulted in salvage of the graft with restoration of kidney...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.02.139

    authors： Maione C,Gambino G,Di Bona A,Luna E,Turco D,Scio A,Damiano G,Virzì C,Gioviale MC,Buscemi G,Romano M,Lo Monte AI

    更新日期：2006-05-01 00:00:00

  • Assessment of gastrointestinal motility in renal transplant recipients by alternate current biosusceptometry.

    abstract：BACKGROUND:Gastrointestinal (GI) complications are common after renal transplantation, mainly owing to immunosuppressive therapy. Assessment of GI transit time can facilitate rational management of these disorders. OBJECTIVE:We evaluate the GI transit parameters in renal transplant recipients taking tacrolimus, azathi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.07.048

    authors： Teixeira MC,Magalhães I,Galvão PV,Souza GS,Miranda JR,Oliveira RB,Corá LA

    更新日期：2012-10-01 00:00:00

  • New concepts in organ transplantation.

    abstract：:Major progress has been made in clinical transplantation over recent years due to close cooperation between clinical specialists and academic investigators. High success rates are evident by longer patient and graft survivals. Treatment procedures have been integrated into fixed protocols utilizing new chemical immuno...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2004.05.051

    authors： Paczek L,Pawlowska M,Krawczyk M,Rowinski W

    更新日期：2004-06-01 00:00:00

  • Exercise Training for Liver Transplant Candidates.

    abstract：BACKGROUND AND AIMS:Frailty is associated with increased morbidity and mortality, and this is tightly linked to liver decompensation and increased complication rates among liver transplant (LT) candidates. The aim of the study was to evaluate the efficacy of a structured in- and outpatient exercise training program for...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.08.045

    authors： Al-Judaibi B,Alqalami I,Sey M,Qumosani K,Howes N,Sinclair L,Chandok N,Eddin AH,Hernandez-Alejandro R,Marotta P,Teriaky A

    更新日期：2019-12-01 00:00:00

  • Assessment of Pulmonary Hypertension in Lung Transplantation Candidates: Correlation of Doppler Echocardiography With Right Heart Catheterization.

    abstract：BACKGROUND:Right heart catheterization (RHC) remains the gold standard to diagnosis of pulmonary hypertension among lung transplantation candidates. Doppler echocardiography (DE) may be as accurate as RHC, without risks of an invasive test. The aim of the study was to assess the feasibility of DE for the measurement of...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.06.055

    authors： Balcı MK,Arı E,Vayvada M,Salturk C,Aşıcıoğlu E,Kahveci G,Akbal ÖY,Kutlu CA

    更新日期：2016-10-01 00:00:00

  • Improved attainment of NKF classified lipid target levels after conversion from cyclosporine to tacrolimus in renal graft recipients.

    abstract：:In an open, prospective, multicenter study, stable renal graft recipients were converted to tacrolimus because of cyclosporine-related side effects. Seventy-five patients were switched primarily because of hyperlipidemia. After the switch to tacrolimus, mean total cholesterol was reduced by 15% at month 6. One hundred...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.transproceed.2005.03.135

    authors： Pohanka E,Margreiter R,Sparacino V,Sperschneider H,European Switch to Tacrolimus Study Group.

    更新日期：2005-05-01 00:00:00

  • Role of resistive index measurement in diagnosis of acute rejection episodes following successful kidney transplantation.

    abstract：OBJECTIVE:This study was performed to evaluate the role of resistive index (RI) in the diagnosis of rejection episodes following successful kidney transplantation. MATERIALS AND METHODS:One hundred and one unrelated living first kidney allograft adult recipients (75 males and 26 females) of overall mean age of 39 year...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.07.050

    authors： Mehrsai A,Salem S,Ahmadi H,Baradaran N,Taherimahmoudi M,Nikoobakht MR,Rezaeidanesh M,Mansoori D,Pourmand G

    更新日期：2009-09-01 00:00:00

  • The role of the transplant coordinator on tissue donation in Turkey.

    abstract：:While solid organs represent the dramatic and lifesaving aspect of donation after death, the transplantation of tissues from donors after death is a much larger-scale activity that benefits enormous numbers of patients, usually in a life-enhancing rather than a lifesaving manner. Some types of tissue transplantation, ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2003.11.069

    authors： Yücetin L,Keçecioğlu N,Ozenci AM,Söğüncü Y,Islamoğlu K,Ersoy FF

    更新日期：2004-01-01 00:00:00

  • Techniques of vascular control in laparoscopic donor nephrectomy.

    abstract：OBJECTIVES:Laparoscopic donor nephrectomy has become the method of choice for removal of living donor kidneys. The ENDO GIA stapler is commonly used for division of the renal vessels, but it can lead to some loss of graft vascular length. Besides, stapler malfunction can occur. In this study, we report our experience u...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.06.016

    authors： Liu KL,Chiang YJ,Wang HH,Chu SH

    更新日期：2008-09-01 00:00:00

  • Corrected flow time is a good indicator for preload responsiveness during living donor liver donation.

    abstract：BACKGROUND:Corrected flow time (FTc) has been utilized as preload indicator in recent literature. Accurate estimation of preload status during living donor liver donation (LDLD) is important due to fluid restriction. We evaluate the effectiveness of FTc as a surrogate of preload indicator during LDLD. MATERIALS AND ME...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.021

    authors： Su BC,Luo CF,Chang WY,Lee WC,Lin CC

    更新日期：2014-04-01 00:00:00

  • Comparison of postoperative morphine requirements in healthy living liver donors, patients with hepatocellular carcinoma undergoing partial hepatectomy, and liver transplant recipients.

    abstract：OBJECTIVE:To retrospectively evaluate postoperative morphine requirements in healthy living donors undergoing partial hepatectomy and patients with end-stage hepatocellular carcinoma or end-stage liver disease undergoing liver transplantation. PATIENTS AND METHODS:The study included all patients who received intraveno...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.024

    authors： Chen JP,Jawan B,Chen CL,Wang CH,Cheng KW,Wang CC,Concejero AM,Villagomeza E,Huang CJ

    更新日期：2010-04-01 00:00:00

  • Experimental training model of pancreas transplant.

    abstract：UNLABELLED:Pancreas transplant (Ptx) is the gold standard for the treatment of type I diabetes, mainly when associated with renal failure. The number of Ptx is increasing worldwide, but in developing countries, such as Brazil, the number of centers is small and transplant surgeons need to practice the technique. METHO...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.056

    authors： David AI,Aquino CG,Guidoni LR,Moricz A,David-Neto E,Pacheco AM Jr,Szutan LA

    更新日期：2006-07-01 00:00:00

  • Effect of active airway warming on body core temperature during adult liver transplantation.

    abstract：INTRODUCTION:Active inspired gas humidification (AH) preserves body heat and maintains normothermia intraoperatively. However, it is unclear whether AH shows comparable influences during liver transplantation (OLT), which may be affected by both large internal heat loss and external heat supply. Thus, the aim of this s...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2012.05.088

    authors： Han SB,Gwak MS,Choi SJ,Kim MH,Ko JS,Kim GS,Joo HS

    更新日期：2013-01-01 00:00:00

  • Short- and Long-Term Outcomes of Live Donor Renal Allografts From Older and Younger Donors.

    abstract：BACKGROUND:The rising demand for living renal donors has led to the recruitment of older donors. Findings vary, but these grafts appear to survive as long as grafts from standard criteria deceased and expanded criteria deceased donors. We investigated the effects of donor age ≥65 years and the presence or absence of do...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.08.046

    authors： Matsuyama T,Ushigome H,Osaka M,Masuda K,Harada S,Nakamura T,Nobori S,Iida T,Yoshimura N

    更新日期：2018-12-01 00:00:00

  • Simple evaluation of engraftment by secretory unit of islet transplant objects for living donor and cadaveric donor fresh or cultured islet transplantation.

    abstract：BACKGROUND:Evaluation of engraftment is important to assess the success of islet transplantation. Recently we developed secretory unit of islet transplant objects (SUITO) index for simple evaluation of engraftment. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, SUITO index was cal...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.09.045

    authors： Matsumoto S,Yamada Y,Okitsu T,Iwanaga Y,Noguchi H,Nagata H,Yonekawa Y,Nakai Y,Ueda M,Ishii A,Yabunaka E,Tanaka K

    更新日期：2005-10-01 00:00:00

  • Successful Ultrasound-Guided Percutaneous Drainage of Multiple Splenic Abscesses in a Kidney Transplant Patient With Encapsulated Sclerosing Peritonitis: A Case Report.

    abstract：:Differential diagnosis of post-transplant infections should include rare/uncommon foci and pathogens. We present a rare case of life-threatening infection, a splenic abscess in a 53-year-old woman who was transplanted with a cadaveric kidney 5 months previously. The patient was admitted to our clinic with chills, shiv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.04.063

    authors： Tuğcu M,Ruhi Ç,Boynueğri B,Kasapoğlu U,Can Ö,Kiliçoğlu G,Şahin G,Titiz M

    更新日期：2015-06-01 00:00:00

  • BK virus nephropathy in renal transplant recipients in Kuwait: a preliminary report.

    abstract：INTRODUCTION:BK virus nephropathy (BKVN) is a significant cause of graft loss among renal transplant recipients. The treatment outcomes of BKVN have been variably reported in the literature. PATIENTS AND METHODS:We prospectively investigated BKV infection and BKVN among a population of renal transplant recipients with...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.08.018

    authors： Nampoory MR,Johny KV,Pacsa A,Nair PM,Said T,Halim MA,Francis I,Samhan M,Mousawi M,Dalawi A,Szucs G,Al-Nakib W

    更新日期：2005-09-01 00:00:00

  • Simultaneous pancreas-kidney transplantation: is the failure of the grafts also simultaneous?

    abstract：INTRODUCTION:It is well known that after a simultaneous pancreas and kidney transplantation (SPKT) there is a higher incidence of pancreatic graft loss in the acute period, due to technical problems. However, there is little information about the survival of pancreatic and kidney grafts 1 year after transplantation. A...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.07.007

    authors： Nicolau J,Ricart MJ,Astudillo E,Esmatjes E,Oppenheimer F,Fernández-Cruz L

    更新日期：2007-09-01 00:00:00

  • Nonmarginal-donor duodenal ulcers caused by rejection after simultaneous pancreas and kidney transplantation: a case report.

    abstract：OBJECTIVE:Pancreas transplantation has been associated with the highest surgical complication rate among routinely performed organ transplant procedures. Complications can be caused not only from the pancreas itself but also from the simultaneously transplanted duodenum: gastrointestinal bleeding, duodenal ulcer, pseud...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.09.094

    authors： Miyagi S,Sekiguchi S,Kawagishi N,Akamatsu Y,Satoh K,Takeda I,Fujimori K,Satomi S

    更新日期：2011-11-01 00:00:00

  • Restricting cadaveric kidney transplantation based on age: the impact on efficiency and equity.

    abstract：BACKGROUND:Caring for patients with end-stage renal disease (ESRD) is resource intense, and health care costs for this small segment of the population continue to rise. When compared to long-term dialysis as a therapy for ESRD, kidney transplantation increases survival, improves quality of life, and is cost saving. ME...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.019

    authors： Quinn RR,Manns BJ,McLaughlin KM

    更新日期：2007-06-01 00:00:00

  • Conversion to everolimus in liver transplant patients with renal dysfunction.

    abstract：:Calcineurin inhibitor (CNI) immunosuppressive therapy post-liver transplantation (OLT) is important to reduce graft rejection episodes. However, these drugs show important side effects, particularly renal dysfunction (RDF). Changing from CNI to a nonnephrotoxic drug, as mammalian target of rapamycin (mTOR) inhibitor m...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.06.009

    authors： Pérez T,Segovia R,Castro L,Roblero JP,Estela R

    更新日期：2011-07-01 00:00:00

  • Arterial anastomosis disrupton in two kidney recipients of contaminated grafts from a donor with Gorham's syndrome.

    abstract：:Transmission of donor infections to immunosuppressed recipients may produce serious complications. Here, we report two cases of ruptured renal artery pseudoaneurysm within a few months after renal transplantation from a donor with Gorham's syndrome, a rare disease characterized by proliferation of vascular and lymphat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2004.04.082

    authors： Saidi RF,Fasola C,El-Ghoroury M,Oh H

    更新日期：2004-06-01 00:00:00

  • Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program.

    abstract：:This paper reviews the formulation and evolution of the ethical component in one of the earliest clinical composite tissue allograft (CTA) programs, the hand transplantation program in Louisville, Kentucky, USA. The purpose was to derive lessons and define principles to give guidance for future programs and introducti...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2004.12.179

    authors： Tobin GR,Breidenbach WC,Klapheke MM,Bentley FR,Pidwell DJ,Simmons PD

    更新日期：2005-03-01 00:00:00

  • Effects of the antioxidants lycium barbarum and ascorbic acid on reperfusion liver injury in rats.

    abstract：OBJECTIVE:Ischemia/reperfusion (I/R) of the rat liver can induce liver injury through mechanisms involving oxidative and nitrosative stresses. In this study we examined the effects of antioxidants Lycium barbarum (LB) and ascorbic acid on I/R-induced liver injury in rats. METHODS:Liver ischemia was induced by clamping...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.051

    authors： Wang NT,Lin HI,Yeh DY,Chou TY,Chen CF,Leu FC,Wang D,Hu RT

    更新日期：2009-12-01 00:00:00

  • Listing Malignant Melanoma Patients for Renal Transplantation.

    abstract：BACKGROUND:Melanoma is an immune responsive malignancy and the need for immunosuppression for successful transplantation may lead to recurrent disease. The recommended waiting time is unknown with various groups recommending anywhere from no wait to 5 years. METHODS:In this single-center, retrospective observational s...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.04.1823

    authors： Qaqish S,Datta N,Bunnapradist S,Lum EL

    更新日期：2020-12-01 00:00:00

  • Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model.

    abstract：:A modified immunosuppressive regimen, developed at the National Institutes of Health, has been employed in a large animal model of heterotopic cardiac xenotransplantation. Graft survival has been prolonged, but despite this, our recipients have succumbed to various surgical or nonsurgical complications. Herein, we hav...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.05.116

    authors： Corcoran PC,Horvath KA,Singh AK,Hoyt RF Jr,Thomas ML 3rd,Eckhaus MA,Mohiuddin MM

    更新日期：2010-07-01 00:00:00

  • Contamination of the Preservation Solution in Solid Organ Transplantation.

    abstract：INTRODUCTION:Preservation solutions (PS), in which grafts for patients undergoing liver transplantation are stored, represent a medium suitable for microorganism growth and a potential source for transmission of pathogenic germs to the transplant recipients. The aim of the present study was to review the relevant liter...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2019.01.070

    authors： Sotiropoulos GC,Kostakis ID,Prodromidou A,Garoufalia Z,Stamopoulos P,Machairas N

    更新日期：2019-03-01 00:00:00

  • Alpha-interferon with ribavirin in the treatment of hemodialysis patients with hepatitis C.

    abstract：INTRODUCTION:Hepatitis C Viral (HCV) infection is the leading cause of chronic liver disease in end-stage renal disease patients (ESRD). The impact of HCV on patient and graft survival posttransplantation is controversial. The most successful approach is to eliminate the virus while the patient is on dialysis prior to ...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.transproceed.2004.07.025

    authors： Mousa DH,Abdalla AH,Al-Shoail G,Al-Sulaiman MH,Al-Hawas FA,Al-Khader AA

    更新日期：2004-07-01 00:00:00