当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Conversion to everolimus in liver transplant patients with renal dysfunction.

Conversion to everolimus in liver transplant patients with renal dysfunction.

Abstract：

:Calcineurin inhibitor (CNI) immunosuppressive therapy post-liver transplantation (OLT) is important to reduce graft rejection episodes. However, these drugs show important side effects, particularly renal dysfunction (RDF). Changing from CNI to a nonnephrotoxic drug, as mammalian target of rapamycin (mTOR) inhibitor may solve the problem. Our objective was to evaluate renal function (RF) among liver transplant patients initially receiving CNI, among whom the patients with RDF were converted completely or partially to an mTOR inhibitor like everolimus (EVE). We performed a prospective study in liver transplant patients from 2000 to 2009. Creatinine levels and creatinine clearances (Cockroft-Gault) expressed as mean values ± standard deviations were measured pre- and postswitch for comparisons using Wilcoxon nonparametric tests. Six patients were converted fully or partially to EVE. Their mean age at the moment of introducing the new therapy was 52.2 ± 13.6 years (range = 28-60). Immunosuppression time prior to switching from CNI to EVE was 23.8 ± 26.6 months (range = 6-70). Postconversion follow-up was 25.8 ± 16.5 months (range = 8-42). All patients showed improvement in RF. The creatinine level improvement was significant (P = .03) namely, from a mean of 2.26 ± 0.49 to 1.21 ± 0.57 mg/dL. Glomerular filtration rate improved from a mean of 40 ± 15.13 to 72.60 ± 17.3 mL/min/m(2) (P = .03). Conversion from CNI to EVE improved creatinine concentrations and creatinine clearances with long-term effects free of graft rejection.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Pérez T,Segovia R,Castro L,Roblero JP,Estela R

doi

10.1016/j.transproceed.2011.06.009

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

2307-10

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(11)00817-7

journal_volume

43

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • De novo colorectal cancer: five-year survival is markedly lower in transplant recipients compared with the general population.

    abstract：INTRODUCTION:The biological behavior of most solid tumors in transplant recipients has not been adequately compared to the general population. The purpose of the present study was to compare outcomes in de novo colorectal cancer (CRC) following solid organ transplantation to those observed in the general population (SE...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.122

    authors： Buell JF,Papaconstantinou HT,Skalow B,Hanaway MJ,Alloway RR,Woodle ES

    更新日期：2005-03-01 00:00:00

  • The outcome of diverticulosis in kidney recipients with polycystic kidney disease.

    abstract：INTRODUCTION:Diverticulosis is a common finding in autosomal-dominant polycystic kidney disease (ADPKD). To avoid the serious complications of diverticulosis after kidney transplantation, some policies have recommended aggressive actions, such as elective colectomy. These policies are not widely agreed upon. This contr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.02.007

    authors： Pourfarziani V,Mousavi-Nayeeni SM,Ghaheri H,Assari S,Saadat SH,Panahi F,Noorbala MH,Vasei A,Norouzi AR,Simforoosh N

    更新日期：2007-05-01 00:00:00

  • Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus.

    abstract：:A 2-center retrospective analysis was performed in 60 patients undergoing liver transplantation for hepatitis C virus (HCV)-related disease (cyclosporine in 20, tacrolimus in 40). Mean (±SEM) follow-up was 23.6 ± 22.5 and 22.3 ± 13.7 months in patients receiving cyclosporine or tacrolimus, respectively. Clinically ind...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2010.10.013

    authors： van der Laan LJ,Hudson M,McPherson S,Zondervan PE,Thomas RC,Kwekkeboom J,Lindsay AS,Burt AD,Kazemier G,Tilanus HW,Bassendine MF,Metselaar HJ

    更新日期：2010-12-01 00:00:00

  • Minimum-Dose, Short-Term Methotrexate With Tacrolimus for Graft-vs-Host Disease Prophylaxis Following Unrelated Cord Blood Transplantation in Adults: A Retrospective Analysis at a Single Institution.

    abstract：BACKGROUND:Methotrexate (MTX) or mycophenolate mofetil with tacrolimus (TAC) is used for graft-vs-host disease (GVHD) prophylaxis in unrelated cord blood transplantation (CBT). However, there is no consensus regimen for GVHD prophylaxis in CBT. We aimed to assess the efficacy and feasibility of minimum-dose, short-term...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.10.018

    authors： Iino M,Sato T,Sakamoto Y

    更新日期：2021-01-01 00:00:00

  • Screening and analysis of porcine endogenous retrovirus in Chinese Banna minipig inbred line.

    abstract：:Pigs have been the most likely animal as the source of cells, tissues, and organs for xenotransplantation. But the use of pigs in xenotransplantation is associated with the risk of porcine endogenous retrovirus (PERV) transmission. Previous studies have identified that the proviruses are integrated into the genome of ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.07.055

    authors： Yu P,Zhang L,Li S,Li Y,Cheng J,Lu Y,Zeng Y,Bu H

    更新日期：2004-10-01 00:00:00

  • Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus.

    abstract：OBJECTIVE:To establish 2 models of long-term chronic allograft rejection (CR) of orthotopic small bowel transplantation (OSBT) using cyclosporine (CsA) or tacrolimus (FK506). METHODS:F344 and Lewis rats served as donors and recipients respectively for OSBT. In the study 1, the rat was administered CsA (5 mg/kg/d) intr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.12.012

    authors： Li Y,Zhu Y,Wang J,Wei W,Wu B,Li J

    更新日期：2013-06-01 00:00:00

  • Evaluation of Epstein-Barr virus-specific immunologic response in solid organ transplant recipients with an enzyme-linked ImmunoSpot assay.

    abstract：:Epstein-Barr virus (EBV) is a γ-herpes virus, responsible for infectious mononucleosis in immunocompetent hosts. Cellular immunity appears rapidly during EBV primary infection, keeping it silent despite long-life persistence in B lymphocytes. Defects of the EBV-specific cellular immunity are supposed to be the basis o...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.07.033

    authors： Rittà M,Costa C,Sinesi F,Sidoti F,Di Nauta A,Mantovani S,Piceghello A,Simeone S,Ricci D,Boffini M,Solidoro P,Baldi S,Segoloni GP,Cavallo R

    更新日期：2013-09-01 00:00:00

  • Liver transplantation in pigs with small-for-size grafts: effect of portocaval shunt.

    abstract：:Small-for-size livers are associated with graft dysfunction, probably due to portal hyperperfusion. Modulation of the recipient portal inflow is a new option in these cases. This article sought to analyze the effect of portocaval shunt in small-for-size liver grafts in pigs. Twelve liver transplants were performed in ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.03.054

    authors： Reichert PR,Pires JS,Sallet CA,Brun MV,Vesco JD,Bonadeo NM,Missel J,Sossela R,Rodrigues R,Fracasso JI,Malheiros AV,Bajerski JC,Annes RD,Guimarães TT,Santos FC,Ben AJ,Gressler M,Wolff NM,Winkelmann G,Manzatto LB,Sa

    更新日期：2004-05-01 00:00:00

  • Why we consistently use the left donor kidney in living related transplantation: initial experience of right laparoscopic donor nephrectomy and comparison with left nephrectomy.

    abstract：OBJECTIVES:Laparoscopic donor nephrectomy has become the method of choice for removal of living donor kidneys. However, the majority of laparoscopic donor nephrectomy cases have been limited to the left side owing to technical difficulties and renal vessel length. This study described the technique and compared donor o...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.023

    authors： Liu KL,Chiang YJ,Wu CT,Lai WJ,Wang HH,Chu SH

    更新日期：2006-09-01 00:00:00

  • Impact of Histological Factors of Hepatocellular Carcinoma on the Outcome of Liver Transplantation.

    abstract：BACKGROUND:The aim of this study was to identify predictors of overall survival (OS), disease-free survival (DFS), and recurrence in a cohort of 151 patients with hepatocellular carcinoma (HCC) and cirrhosis who were treated by liver transplantation (LT). PATIENTS AND METHODS:A retrospective database of patients under...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.04.002

    authors： Donat M,Alonso S,Pereira F,Ferrero E,Carrión L,Acin-Gándara D,Moreno E

    更新日期：2016-07-01 00:00:00

  • Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells.

    abstract：:Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection episodes (ARE) and potential tolerogenic properties. We analyzed the clinical outcomes and effects on p...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.03.066

    authors： Morales J,Bono MR,Fierro A,Iñiguez R,Zehnder C,Rosemblatt M,Calabran L,Herzog C,Benavente D,Aguiló J,Pefaur J,Alba A,Ferrario M,Simon W,Contreras L,Buckel E

    更新日期：2008-11-01 00:00:00

  • Excellent long-term results in de novo renal transplant recipients treated with proliferation signal inhibitors and reduced calcineurin inhibitors exposure.

    abstract：BACKGROUND:A new class of immunosuppressants, proliferation signal inhibitors (PSI)--sirolimus and everolimus--has the potential to prevent chronic allograft nephropathy (CAN). This retrospective analysis reports a 6-year practice using PSI at a single center, comparing a regimen based on reduced-dose calcineurin inhib...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.05.047

    authors： Carmellini M,Collini A,Ruggieri G,Garosi G,Bernini M

    更新日期：2008-07-01 00:00:00

  • Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Liver Transplant Patient: A Case Report.

    abstract：:Intraoperative extracorporeal membrane oxygenation (ECMO) support, both venoarterial and venovenous (VV), have been used sparingly and with limited success in the setting of liver transplantation. Here, we report the successful use of VV-ECMO in the resuscitation and pulmonary bridging support after severe systemic in...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.07.013

    authors： Kim IK,Nissen NN,Steggerda J,Gereboff A,Sharma V,Kariger R,Klein AS,Annamalai A,Todo T,Nurok M,Dong E,Friedman O,Jordan SC,Ramzy D

    更新日期：2018-12-01 00:00:00

  • Management of uncommon hernias in cirrhotic patients.

    abstract：BACKGROUND:Abdominal hernias are a common disease among cirrhotic patients, because of malnutrition and persistently high intra-abdominal pressure due to ascites. When tense ascites is present, life-threatening complications are likely to occur. In such cases, the morbidity and mortality rates are high. OBJECTIVE:We d...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.090

    authors： Andraus W,Sepulveda A,Pinheiro RS,Teixeira AR,D'Albuquerque LA

    更新日期：2010-06-01 00:00:00

  • Selective use of expanded criteria donors for renal transplantation with good results.

    abstract：:Increasing demand for renal transplants has stimulated expanded criteria for the use of deceased donors. Recently an official category of "Expanded Criteria Donors" (ECD) was designated by UNOS. This category included any deceased donor (1) greater than age 60 years or (2) age 50 to 59 years with any two of: (a) creat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.062

    authors： Greenstein SM,Schwartz G,Schechner R,Pullman J,Jackness C,Tellis V

    更新日期：2006-12-01 00:00:00

  • Best results in living donor transplantation using an aggressive policy in microsurgical bench reconstruction of nonoptimal arterial supply.

    abstract：:The increasing of number of patients awaiting kidney transplantation have forced surgeons to use nonoptimal organs, such as kidneys with multiple/diseased arteries as well as those coming from living donors (LDs). Two hundred and sixty six LD transplants performed in cyclosporine era included 44 coming from a LD over ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.03.062

    authors： Berardinelli L

    更新日期：2006-05-01 00:00:00

  • Living Kidney Transplantation From Marginal Donors Presents Feasible Donor Renal Function Despite Inferior Recipient Renal Function.

    abstract：INTRODUCTION:Kidney transplantation from marginal donors is an important solution for organ shortage problems. In this study, we evaluated the safety and effectiveness of living kidney transplantation from marginal donors at our hospitals. METHODS:Between June 2006 and April 2019, 107 patients underwent living kidney ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.01.157

    authors： Hamano I,Hatakeyama S,Fujita T,Murakami R,Hamaya T,Togashi K,Suzuki Y,Yamamoto H,Yoneyama T,Yoneyama T,Hashimoto Y,Narumi S,Tomita H,Ohyama C

    更新日期：2020-01-01 00:00:00

  • Early postoperative spectral Doppler parameters of renal transplants: the effect of donor and recipient factors.

    abstract：BACKGROUND:The objective of this study was to explore the donor and recipient factors related to the spectral Doppler parameters of the transplant kidney in the early posttransplantation period. METHODS:This retrospective study included 76 patients who underwent renal transplantation assessed using Doppler ultrasonogr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.12.069

    authors： Wang HK,Chiou SY,Lai YC,Cheng HY,Lin NC,Loong CC,Chiou HJ,Chou YH,Chang CY

    更新日期：2012-01-01 00:00:00

  • Impact of combined mycophenolate mofetil and low-dose calcineurin inhibitor therapy on renal function, cardiovascular risk factors, and graft function in liver transplant patients: preliminary results of an open prospective study.

    abstract：:As liver transplantation (LT) is now being performed with excellent 1-year graft survival rates of 85% to 90%, attention has been shifted to reducing long-term complications of calcineurin inhibitors (CNI). We randomized LT patients (2:1) who displayed renal dysfunction under CNI treatment to either mycophenolate mofe...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2004.10.008

    authors： Beckebaum S,Cicinnati VR,Klein CG,Brokalaki E,Yu Z,Malago M,Frilling A,Gerken G,Broelsch CE

    更新日期：2004-11-01 00:00:00

  • Decrease in serum tacrolimus level and rise in serum creatinine under late addition of cinacalcet in a renal transplant recipient with hyperparathyroidism: a case report.

    abstract：:Cinacalcet is a calcimimetic drug that has been approved for treatment of secondary and tertiary hyperparathyroidism in patients with renal failure requiring renal replacement therapy. A few cases of successful treatment in renal transplant patients immunosuppressed with cyclosporine have been reported. Herein we have...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.07.088

    authors： Maass E,Mueller GA,Heller T,Koziolek MJ

    更新日期：2007-12-01 00:00:00

  • Frozen-section diagnosis in donor livers: error rate estimation of steatosis degree.

    abstract：:A high degree of macrovesicular steatosis is associated with a significant risk of graft dysfunction. Most centers, including ours, consider 60% the limit value for transplantability, while others have adopted 30% as a cutoff. Pretransplant frozen-section (PFS) evaluation is used for reliable quantification of steatos...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.05.033

    authors： D'Alessandro E,Calabrese F,Gringeri E,Valente M

    更新日期：2010-07-01 00:00:00

  • Depression and anxiety in living kidney donation: evaluation of donors and recipients.

    abstract：BACKGROUND:Psychosocial status of donors before and after living kidney donor transplantation has been an important concern. Investigations of psychosocial issues in related recipients are not frequent. AIM:The aims of this study were to evaluate and compare psychopathologic dimensions in donors and recipients before ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.12.028

    authors： Lopes A,Frade IC,Teixeira L,Oliveira C,Almeida M,Dias L,Henriques AC

    更新日期：2011-01-01 00:00:00

  • Long-term Outcomes of ABO-Incompatible Living Donor Kidney Transplantation: A Comparative Analysis.

    abstract：BACKGROUND:Although ABO-incompatible kidney transplantation has become more common due to organ shortage, few studies on long-term outcomes have been performed in the Korean population. METHODS:A retrospective review of medical records was conducted for individuals who underwent living donor kidney transplantation at ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.05.026

    authors： Shin E,Kwon SW,Yang WS,Baeck C,Yu H,Cho H,Park SK

    更新日期：2015-07-01 00:00:00

  • Influence of everolimus on cyclosporine Neoral pharmacokinetics in Chinese de novo cardiac transplant recipients.

    abstract：OBJECTIVE:This study sought to determine the influence of everolimus on cyclosporine Neoral (CsA) pharmacokinetics over the first 6 months after heart transplantation in Chinese recipients. METHODS:Six de novo cardiac recipients receiving a CsA-everolimus-based immunosuppressive regimen after rabbit antithymoglobulin ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.038

    authors： Wang CH,Chou NK,Wu FL,Ko WJ,Tsao CI,Chi NH,Hsu RB,Wang SS

    更新日期：2006-09-01 00:00:00

  • Evolution of Organ Transplantation in Poland 1966 to 2014: Dates and Numbers.

    abstract：BACKGROUND:Several events inspired us to collect data on organ transplantation in Poland (2016: the 50th anniversary of the first transplantation and the 20th anniversary of Polish Transplant Coordinating Center Poltransplant). The paper aims at presenting comprehensive data on all organ transplants, beginning with the...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.01.042

    authors： Czerwiński J,Czapiewski W,Danielewska E,Milaniak I,Milecka A,Patrzałek D,Sekta S,Saucha W,Danek T,Zając K,Ostrowski K,Malanowski P

    更新日期：2016-06-01 00:00:00

  • Selenium homocholic acid taurocholate scanning, selenium-75-labeled bile acid, a novel method for testing the function of the terminal ileum in small bowel transplant recipients: a pilot study.

    abstract：INTRODUCTION:The terminal ileum (TI) is important for the active reabsorption of bile salts and is the site of allograft rejection; disruption of enterohepatic circulation (EHC) may give insights to inflammatory and other physiologic processes at the TI. SUBJECTS AND METHODS:Four children aged 5 to 12 years who had re...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.036

    authors： Beath SV,Lanchbury E,Alton H,Mahandru R,Toy M,van Mouirk ID,McKiernan PJ,Hartley J,Kelly DA,Sharif K,Gupte G

    更新日期：2014-07-01 00:00:00

  • Impact of Early Low-Grade Proteinuria and Allograft Dysfunction on Survival in Expanded Criteria Donor Kidney Transplant Recipients.

    abstract：INTRODUCTION:Recent studies have demonstrated a relationship between low-grade proteinuria and worse graft survival, but this has not been fully studied in expanded criteria donor (ECD) kidney transplant recipients. AIM:The aim of this study was to assess whether the combination of early low-grade proteinuria (<1 g/d)...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.08.045

    authors： López V,Cabello M,Ruíz-Esteban P,Sola E,Gutiérrez C,Jironda C,Burgos D,González-Molina M,Hernández D

    更新日期：2015-11-01 00:00:00

  • An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients.

    abstract：:Mycophenolate mofetil (MMF) is an immunosuppressant used for the prophylaxis of rejection in renal, pancreas, and liver transplantation. It inhibits the inducible isoform of the enzyme inosine-monophosphate dehydrogenase (IMPDH II) via its active metabolite mycophenolic acid (MPA). IMPDH II is necessary for de novo pu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.070

    authors： Vannozzi F,Filipponi F,Di Paolo A,Danesi R,Urbani L,Bocci G,Catalano G,De Simone P,Mosca F,Del Tacca M

    更新日期：2004-11-01 00:00:00

  • Police Officers' Knowledge and Attitudes Toward Brain Death and Organ Donation in Korea.

    abstract：BACKGROUND:Administrative processing by the police may affect the process involved in organ donation in the event of an accidental brain injury. The purpose of this study was to evaluate the knowledge and attitude of police toward brain-dead donors and organ donation. METHODS:This was a descriptive research study usin...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.049

    authors： Kim HS,Yoo YS,Cho OH,Lee CE,Choi YH,Kim HJ,Park JY,Park HS,Kwon YJ

    更新日期：2018-05-01 00:00:00

  • More Hippocampal Weight and Cells in Cardiac Allograft Transplanted Mice.

    abstract：:The hippocampus is a brain structure that plays a fundamental role in memory and learning. Many animal studies have demonstrated that the structure of the hippocampus has evolved through exercise and play. However, little is known on the relationship between the brain and immunological reaction. In this study, we inve...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.03.107

    authors： Yin E,Uchiyama M,Jin X,Kawai K,Takao M,Niimi M

    更新日期：2018-11-01 00:00:00