Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus.

Abstract:

:A 2-center retrospective analysis was performed in 60 patients undergoing liver transplantation for hepatitis C virus (HCV)-related disease (cyclosporine in 20, tacrolimus in 40). Mean (±SEM) follow-up was 23.6 ± 22.5 and 22.3 ± 13.7 months in patients receiving cyclosporine or tacrolimus, respectively. Clinically indicated biopsies were performed in 15/20 cyclosporine patients (75%) and 22/40 tacrolimus patients (55%; P = .17). The Ishak fibrosis score was significantly lower in cyclosporine-treated patients versus tacrolimus-treated patients (mean 1.7 ± 0.4 vs 3.1 ± 0.4; P = .023), as was percentage of fibrosis grade Ishak ≥4 (7% vs 41%; P = .028). The mean time to moderate fibrosis (Ishak score ≥3) was 38.2 ± 15.1 months in cyclosporine patients (4/15) and 23.5 ± 12.6 months in tacrolimus patients (14/22); the difference was not statistically significant (P = .09). This retrospective study suggests that cyclosporine-based immunosuppression is associated with less severe hepatic fibrosis in HCV-positive liver transplant recipients compared with tacrolimus-based regimens, but a larger prospective comparative trial is necessary to confirm these findings.

journal_name

Transplant Proc

authors

van der Laan LJ,Hudson M,McPherson S,Zondervan PE,Thomas RC,Kwekkeboom J,Lindsay AS,Burt AD,Kazemier G,Tilanus HW,Bassendine MF,Metselaar HJ

doi

10.1016/j.transproceed.2010.10.013

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

4573-7

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)01578-2

journal_volume

42

pub_type

杂志文章,多中心研究
  • Risk factors for BK virus infection and BK virus-associated nephropathy under the impact of intensive monitoring and pre-emptive immunosuppression reduction.

    abstract:BACKGROUND:BK virus (BKV) nephropathy (BKVN) is an increasingly recognized cause of kidney allograft loss and is thought to be related to the newer, more potent immunosuppressive agents. However, the risk factors for different types of BKV infection under the impact of intensive monitoring and reduction of maintenance ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.08.036

    authors: Huang G,Zhang L,Liang X,Qiu J,Deng R,Li J,Chen G,Dong Y,Chen L

    更新日期:2014-12-01 00:00:00

  • Infectious complications in kidney transplant recipients: a single-center experience.

    abstract::To determine the patterns of infectious complications in renal transplant recipients in our center, we evaluated 48 patients (29 men and 19 women) who were transplanted between 1994 and 2003. The average age of the patients was 29 years. Thirty (62.5%) and 18 (37.5%) transplants were from living related and cadaveric ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.05.009

    authors: Charfeddine K,Zaghden S,Kharrat M,Kamoun K,Jarraya F,Hachicha J

    更新日期:2005-07-01 00:00:00

  • Acute stress impairs lymphocyte function but spares pancreatic endocrine function.

    abstract::In the same animal, following HS and recovery, pancreatic islet function remains intact while immunologic functions are impaired. Cellular responses to thermal stresses are complex and tissue specific. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/s0041-1345(97)00225-x

    authors: Rewinski MJ,Krastins M,Schweizer RT,Perdrizet GA

    更新日期:1997-06-01 00:00:00

  • Tacrolimus and Mycophenolic Acid Blood Concentration and Cellular Rejection After Heart Transplantation in First Endomyocardial Biopsy.

    abstract:BACKGROUND:Tacrolimus and mycophenolic acid (MPA) are the most important immunosuppressive drugs in modern heart transplantation. The pharmacokinetics of tacrolimus are best described by a 2-compartment model. MPA has very variable pharmacokinetics. The aim of this research was to compare kinetics of the immunosuppress...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.03.006

    authors: Nadziakiewicz P,Grochla M,Krauchuk A,Szyguła-Jurkiewicz B,Lorek J,Barańska A,Zembala MO,Przybyłowski P

    更新日期:2020-09-01 00:00:00

  • A comparative study of the traditional method, and a point-score system for allocation of deceased-donor kidneys: a national multicenter study in Mexico.

    abstract:BACKGROUND:The National Transplant Center in Mexico has ruled that deceased-donor kidney allocation is a function of each hospital's Internal Transplant Committee. The aim of this study was to compare and analyze results for of the traditional method and a point-score system in the allocation of deceased patient's kidn...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2011.09.091

    authors: Cantú-Quintanilla G,Alberú J,Reyes-Acevedo R,Medeiros M,Villa MS,Arreola JM,Gracida C,Reyes-López A

    更新日期:2011-11-01 00:00:00

  • Natural History of Serum Calcium and Parathyroid Hormone Following Renal Transplantation.

    abstract:BACKGROUND:Hyperparathyroidism is common in end-stage renal disease. It often persists following renal transplantation (RTx) and remains elusive to manage due to the lack of evidence base. We therefore present observational data describing the natural history and management of hypercalcemia and hyperparathyroidism foll...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.09.050

    authors: Al-Moasseb Z,Aitken E

    更新日期:2016-12-01 00:00:00

  • Initial experience with lung transplantation in Estonia.

    abstract:BACKGROUND:A lung transplant program in Estonia was initiated in cooperation with the Medical University of Vienna. The first lung transplantation for an Estonian patient was performed in Vienna on April 28, 2009. The waiting list in Estonia was opened on May 28, 2010; the first transplantation was performed on October...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.10.016

    authors: Laisaar T,Savisaar M,Parm P,Sõrmus A,Kuum U,Ruusalepp A,Jakobson E,Küüsvek A,Klepetko W

    更新日期:2013-04-01 00:00:00

  • Coronary artery calcifications in hemodialysis patients and their correlation with the prevalence of erectile dysfunction.

    abstract:INTRODUCTION:Our aim in this study was to investigate the prevalence and correlation with coronary artery calcium scores (CACS) and erectile dysfunction (ED) among hemodialysis patients. PATIENTS AND METHODS:Thirty-five male patients with chronic renal failure were selected to participate in this study. All patients u...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.11.046

    authors: Inci K,Hazirolan T,Aki FT,Oruc O,Tombul T,Tasar C,Erkan I,Bakkaloglu M,Turgan C,Ergen A

    更新日期:2008-01-01 00:00:00

  • Quality of life after simultaneous pancreas-kidney transplantation.

    abstract::Even recipients with satisfactory function of transplanted pancreas and kidney may show physical and/or social disability due to diabetic complications. Our aims were to evaluate diabetic complications influencing recipient quality of life and to assess patients' psychosociological status. Nineteen patients with funct...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.09.083

    authors: Kwiatkowski A,Michalak G,Czerwinski J,Wszola M,Nosek R,Ostrowski K,Chmura A,Danielewicz R,Lisik W,Adadynski L,Malkowski P,Fesolowicz S,Bieniasz M,Kasprzyk T,Bernas M,Szczeklik-Kumala K,Glowania A,Durlik M,Walaszewski

    更新日期:2005-10-01 00:00:00

  • Experimental model of isolated lung perfusion in rats: first Brazilian experience using the IL-2 isolated perfused rat or guinea pig lung system.

    abstract:INTRODUCTION:Lung transplantation has become the mainstay therapy for patients with end-stage lung disease refractory to medical management. However, the number of patients listed for lung transplantation largely exceeds available donors. The study of lung preservation requires accurate, cost-effective small animal mod...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.01.016

    authors: Pêgo-Fernandes PM,Werebe E,Cardoso PF,Pazetti R,de Oliveira KA,Soares PR,Jatene FB

    更新日期:2010-03-01 00:00:00

  • Identification of hematopoietic cell populations from the dermal papillae of human hair follicles.

    abstract::Hematopoietic stem cell (HSC) activity has been identified from the hair follicles (HFs) in mice; however, it has not been identified in human HFs. We used immunohistochemistry and flow cytometry to identify cultured dermal papilla (DP) cells expressing CD45 to test for hematopoietic activity in colony-forming assays ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.11.104

    authors: Shi C,Mai Y,Cheng T

    更新日期:2004-12-01 00:00:00

  • Survival Benefit of Early Cancer Detection Through Regular Endoscopic Screening for De Novo Gastric and Colorectal Cancers in Korean Liver Transplant Recipients.

    abstract:BACKGROUND:De novo malignancy is not uncommon after liver transplantation (LT). Gastric cancer is one of the most common malignancies in both the Korean general population and LT recipients, and colorectal cancer prevalence is gradually increasing. METHODS:Among 3690 adult recipients who underwent LT from January 1999...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2015.12.003

    authors: Jung DH,Hwang S,Song GW,Ahn CS,Moon DB,Ha TY,Kim KH,Park GC,Kim BS,Park IJ,Lim SB,Kim JC,Yoo MW,Byeon JS,Jung HY,Lee GH,Myung SJ,Choe J,Choi JY,Park HW,Lee SG

    更新日期:2016-01-01 00:00:00

  • Pancreas Transplantation: Small-Center Experience in Type 1 Diabetes Mellitus in a High-Incidence Region.

    abstract:BACKGROUND:Pancreas transplantation (PT) is the best option of care for patients with type I diabetes mellitus (T1DM). METHODS:From July 2005 to September 2014, we performed 27 PT from deceased donors (24 simultaneous pancreas-kidney transplantations [SPKT] and 3 pancreas transplantations alone) in a region with a hig...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.11.070

    authors: Tondolo V,Manunza R,Pellegrino RA,Zamboni F

    更新日期:2015-09-01 00:00:00

  • Beneficial effects of fluvastatin on progressive renal allograft dysfunction.

    abstract::To assess the time-dependent changes in renal function in relation to antioxidant and lipid-lowering effects of fluvastatin in hyperlipidemic renal transplant recipients, 20 patients were treated with fluvastatin 40 mg/d for 12 months, after failure of a dietary program. Plasma malondialdehyde (MDA) levels and lipid p...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0041-1345(03)00376-2

    authors: Konstadinidou I,Boletis JN,Perrea D,Triantafyllou A,Filiopoulos V,Stamataki E,Kostakis A,Stathakis ChP

    更新日期:2003-06-01 00:00:00

  • Histologic studies of islets of Langerhans in transplanted pancreata from marginal donors in Japan.

    abstract::The serious shortage of brain-dead donors leads to the use of pancreata from marginal donors, including cardiac death in Japan. We studied the islet histology of pancreas graft biopsies to investigate the adequacy of using pancreata from marginal donors. Pancreas allograft biopsy was performed originally to diagnose a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.02.080

    authors: Ishida-Oku M,Iwase M,Sugitani A,Masutani K,Kitada H,Tanaka M,Iida M

    更新日期:2010-06-01 00:00:00

  • Results of urgent liver retransplantation in the state of São Paulo, Brazil.

    abstract::The treatment of end-stage liver disease includes transplantation as a life-saving procedure although it has serious complications of hepatic artery thrombosis, liver dysfunction, or primary nonfunction, which frequently lead to the need for retransplantation. According to various reports, the incidence of retransplan...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.06.073

    authors: Ferraz-Neto BH,Zurstrassen MP,Hidalgo R,Rezende MB,Meira-Filho SP,Pandullo FL,Fonseca LE,Pereira LA,Afonso RC

    更新日期:2006-07-01 00:00:00

  • Use of Georges Lopez Institute Preservation Solution IGL-1 in Pancreas Transplantation: A Series of 47 Cases.

    abstract:BACKGROUND:Graft preservation continues to be one of the main pillars of pancreas transplantation (PT). Surgical complications, possibly caused or facilitated by organ damage during preservation, continue to occur more frequently after PT than for any other abdominal organ. During the past few years, the Georges Lopez ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.02.006

    authors: Igreja MR,Wiederkehr JC,Wiederkehr BA,Maykon Massutti A,de Aguiar Wiederkehr H

    更新日期:2018-04-01 00:00:00

  • Rhabdomyolysis after liver transplantation: a case report.

    abstract::Our aim was to present the case of a pediatric biliary atresia patient who experienced rhabdomyolysis with severe cardiac arrhythmias associated with hyperkalemia, metabolic acidosis, and myoglobulinemia during liver transplantation. A 5-year-old girl, weighing 16.5 kg, with end-stage liver disease due to biliary atre...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.07.032

    authors: Huang CJ,Chen CL,Wang CS,Cheng KW,Chen KH,Wang CC,Concejero AM,Cheng YF,Huang TL,Chiu KW,Wang SH,Lin CC,Liu YW,Jawan B

    更新日期:2008-10-01 00:00:00

  • Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:--a case report.

    abstract:UNLABELLED:We generated an human embryonic stem cell (hESC) line to augment chimerism-associated tolerance. A 40-year-old African with chronic glomerulonephritis-chronic renal failure with 100% G6PD enzyme deficiency presented for renal transplantation with a 27-year-old, 6/6 HLA-matched sister as a willing donor. MET...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.08.173

    authors: Trivedi HL,Mishra VV,Vanikar AV,Modi PR,Shah VR,Shah PR,Firoz A

    更新日期:2006-11-01 00:00:00

  • Accuracy of noninvasive estimation of pulmonary wedge pressure by echocardiographic indices in heart transplant recipients.

    abstract:BACKGROUND:Pulmonary capillary wedge pressure (PCWP) can be estimated from transmitral or color M-mode Doppler flow propagation velocities. However, it has been recommended to not use these indices in heart transplant recipients. Our aim was to compare the accuracy of color M-mode, Doppler, and Doppler tissue imaging (...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.09.058

    authors: López B,Sanchez V,Delgado JF,Casares SF,Mora L,García J,Lombera F,Forteza A,Cortina JM,Saenz de la Calzada C

    更新日期:2012-11-01 00:00:00

  • Successful treatment of invasive mucormycosis in a liver transplant patient by arm amputation.

    abstract::Mucormycosis is an uncommon but frequently fatal infectious complication after solid organ transplantation. We describe successful treatment of invasive mucormycosis in a liver transplant recipient by wound debridement, a right above-elbow arm amputation, and antifungal medications. Early recognition, prompt operative...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.06.001

    authors: Iida T,Sawada N,Takahashi M,Zendejas IR,Kayler LK,Magliocca JF,Kim RD,Hemming AW,Fujita S

    更新日期:2010-09-01 00:00:00

  • Mars and Prometheus: our clinical experience in acute chronic liver failure.

    abstract:INTRODUCTION:In our clinical context, there are two groups that practice blood purification treatments on acute or chronic liver failure (AoCLF) patients: one group used MARS (molecular adsorbent recirculating system) and the other Prometheus. MATERIALS AND METHODS:The MARS group used the lack of response to standard ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.03.069

    authors: Faenza S,Baraldi O,Bernardi M,Bolondi L,Coli L,Cucchetti A,Donati G,Gozzetti F,Lauro A,Mancini E,Pinna AD,Piscaglia F,Rasciti L,Ravaioli M,Ruggeri G,Santoro A,Stefoni S

    更新日期:2008-05-01 00:00:00

  • Altered expression of hepatocyte growth factor in cardiac allografts of nonhuman primates.

    abstract::Hepatocyte growth factor (HGF) plays a critical role in transplant rejection. Herein we addressed whether HGF expression could be used for accurate and early diagnosis of acute and chronic rejection in cardiac transplantation. We used a heterotopic cardiac transplantation model using nonhuman primates (Macaca fuscata,...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.075

    authors: Suzuki J,Kawauchi M,Ogawa M,Isobe M

    更新日期:2006-12-01 00:00:00

  • Prognostic Value of Pre-transplantation Serum Alpha-Fetoprotein Levels in Hepatocellular Carcinoma Recurrence.

    abstract::Serum alpha-fetoprotein (AFP) value is still not included in the consensus guidelines to make decisions referring to liver transplantation (LT) for hepatocellular carcinoma (HCC). Many studies demonstrated the influence of high AFP level in poor prognosis after LT for HCC. We studied 301 consecutive recipients transpl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.07.033

    authors: Montalvá EM,Cantos M,Boscà A,Rubín A,Vinaixa C,Granero P,Maupoey J,López-Andújar R

    更新日期:2016-11-01 00:00:00

  • Polytetrafluoroethylene patch venoplasty for outflow reconstruction in living donor liver transplantation: two case reports.

    abstract::Outflow obstruction may lead to liver congestion and eventual graft failure after living donor liver transplantation. Various methods of venoplasty provide wider outflow tracts. Most series have suggested use of autologous or allogenic grafts for patch venoplasty. We used a polytetrafluorethylene patch in two patients...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.07.035

    authors: Chen TH,Jeng LB,Lee CC,Li PC,Huang JC,Hsu CH,Poon KS,Chen YF,Ho YJ,Chuang PH,Lai HC

    更新日期:2008-10-01 00:00:00

  • Impairment in forearm endothelium-dependent vasodilation after heart transplantation.

    abstract:BACKGROUND:Endothelial dysfunction has been found in the peripheral circulation of patients with severe heart failure. However, whether the endothelial dysfunction improves after heart transplantation remains unknown. Our aim was to assess the forearm endothelium-dependent vasoreactivity one and six months after heart ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/s0041-1345(03)00661-4

    authors: Cuppoletti A,Sitges M,Pérez Villa F,Orús J,Magriñá J,Roig E

    更新日期:2003-08-01 00:00:00

  • Liver transplantation for hilar cholangiocarcinoma: a German survey.

    abstract:BACKGROUND:The present study reports a German survey addressing outcomes in nonselected historical series of liver transplantation (OLT) for hilar cholangiocarcinoma (HL). PATIENTS AND METHODS:We sent to all 25 German transplant centers performing OLT a survey that addressed (1) the number of OLTs for HL and the perio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2008.08.039

    authors: Kaiser GM,Sotiropoulos GC,Jauch KW,Löhe F,Hirner A,Kalff JC,Königsrainer A,Steurer W,Senninger N,Brockmann JG,Schlitt HJ,Zülke C,Büchler MW,Schemmer P,Settmacher U,Hauss J,Lippert H,Hopt UT,Otto G,Heiss MM,Bechste

    更新日期:2008-11-01 00:00:00

  • Donor risk index does not predict graft survival after pancreas transplantation in Brazil.

    abstract:BACKGROUND:Pancreas donor risk index (DRI) was developed by using large multicenter American data to predict the risk of adverse outcomes in pancreas transplantation based on donor and technical/logistical characteristics. AIM:The goal of this study was to evaluate the usefulness of the DRI in predicting graft surviva...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.03.034

    authors: Amaral PH,Genzini T,Perosa M,Massarollo PC

    更新日期:2015-05-01 00:00:00

  • Echocardiographic Pulmonary Hypertension Predicts Post-transplantation Renal Allograft Failure.

    abstract:BACKGROUND:Pulmonary hypertension in the setting of renal transplantation has been associated with early allograft dysfunction and increased mortality, but this relationship has not been extensively studied. METHODS:We performed a retrospective cohort study of adult patients who underwent their first renal transplanta...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2017.01.085

    authors: Foderaro AE,Baird GL,Bazargan-Lari A,Morrissey PE,Gohh RY,Poppas A,Klinger JR,Ventetuolo CE

    更新日期:2017-01-01 00:00:00

  • Growth in pediatric renal transplant recipients.

    abstract::One of the fundamental challenges in managing pediatric renal transplant recipient is to ensure normal growth and development. The goal of renal transplant is not just to prolong life but to optimize quality of life. Short stature during childhood may be associated with academic underachievement and development of com...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.03.001

    authors: Vasudevan A,Phadke K

    更新日期:2007-04-01 00:00:00