当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Evaluation of Epstein-Barr virus-specific immunologic response in solid organ transplant recipients with an enzyme-linked ImmunoSpot assay.

Evaluation of Epstein-Barr virus-specific immunologic response in solid organ transplant recipients with an enzyme-linked ImmunoSpot assay.

Abstract：

:Epstein-Barr virus (EBV) is a γ-herpes virus, responsible for infectious mononucleosis in immunocompetent hosts. Cellular immunity appears rapidly during EBV primary infection, keeping it silent despite long-life persistence in B lymphocytes. Defects of the EBV-specific cellular immunity are supposed to be the basis of post-transplantation lymphoproliferative disorders, promoted by high levels of immunosuppression. We retrospectively reviewed 197 solid organ transplant recipients to investigate EBV-specific lymphocyte responsiveness using Enzyme-linked ImmunoSpot assay (EliSpot), which assesses the EBV-specific interferon (IFN)-γ producing peripheral blood mononuclear cells, and kinetics of EBV infection/reactivation post-transplantation using quantitative real-time polymerase chain reaction (PCR) on whole blood. Overall, 102 of the 197 patients (51.8%) showed EBV responsiveness at the EBV-EliSpot assay: 68 (66.6%) showed a persistently positive EBV response in 3 or more determinations and 34 (33.3%) had transient episodes of nonresponsiveness. Ninety-five (48.2%) patients were persistently EBV nonresponders. EBV-DNAemia data were available for 58 patients: 27.6% presented at least one episode of EBV-DNA occurrence. No differences were found in EBV-EliSpot response stratification between the groups of patients who experienced episodes of EBV reactivation and those without EBV-DNAemia. However, EBV DNAemia peak values tended to be higher in the first year post-transplantation in the group of patients with a persistent positive EBV-specific immune response. EBV viral load quantitation in blood and EliSpot EBV-specific immune response determination may represent a powerful tool for monitoring solid organ transplant recipients, guiding immunosuppression modulation in patients with active EBV replication.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Rittà M,Costa C,Sinesi F,Sidoti F,Di Nauta A,Mantovani S,Piceghello A,Simeone S,Ricci D,Boffini M,Solidoro P,Baldi S,Segoloni GP,Cavallo R

doi

10.1016/j.transproceed.2013.07.033

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2754-7

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00663-5

journal_volume

45

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Causes for an Incomplete Donation Process at a Tertiary Care Hospital.

    abstract：INTRODUCTION:This study aims to identify the causes for the incomplete donation process at a tertiary care hospital. MATERIALS AND METHODS:A descriptive, retrospective study was performed; all potential donors reported to the Transplant Service within the period of 2005 to 2014 were included. Descriptive statistics we...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.02.021

    authors： Guerra-Sáenz EK,Narváez-Navarro AG,Hernández-López AC,Rojas-Delgado CE,Ruíz-Cantú G,Cordero-Pérez P,Hernández-Guedea M,Zapata-Chavira H,Escobedo-Villarreal MM,Muñoz-Espinosa L,Pérez Rodríguez E

    更新日期：2016-03-01 00:00:00

  • It takes time after bilateral nephrectomy for better control of resistant hypertension in renal transplant patients.

    abstract：UNLABELLED:Severe resistant hypertension in end-stage renal disease patients has traditionally been an indication for bilateral nephrectomy (BN) before kidney transplantation. Nevertheless the influence of BN on successful control of hypertension has not been well documented. We sought to clarify the effect of BN on bl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.04.014

    authors： Gawish AE,Donia F,Fathi T,Al-Mousawi M,Samhan M

    更新日期：2010-06-01 00:00:00

  • "Passing loop" technique: a new modification of the piggyback technique tailored to voluminous liver grafts--case report.

    abstract：BACKGROUND:The modified piggyback technique with side-to-side cavocavostomy decreases the risk of outflow obstruction compared with the standard piggyback method. However, this modification is not ideal for recipients who receive a graft that is voluminous or bears an enlarged caudate lobe. METHODS:We modified the inf...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.05.094

    authors： Eldeen FZ,Lee CF,Lee CS,Chan KM,Lee WC

    更新日期：2013-03-01 00:00:00

  • Fetal listing for organ transplantation in Canada.

    abstract：:This article presents an ethical and legal examination of whether a fetus should be listed to receive a transplanted organ. To date, relatively little discussion of this question has found its way into either the clinical or ethics literature. This article is divided into four sections. The first section analyzes the ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.153

    authors： Russell BJ

    更新日期：2006-11-01 00:00:00

  • Malignancies after heart transplantation: incidence, risk factors, and effects of calcineurin inhibitor withdrawal.

    abstract：:The objectives of the present study were to evaluate the incidence of malignancies and to describe the effects of immunosuppression on survival and recurrence of malignancies after heart transplantation (HTX). Data were analyzed in 211 cardiac allograft recipients, in whom HTX was performed between 1989 and 2005. All ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.07.107

    authors： Doesch AO,Müller S,Konstandin M,Celik S,Kristen A,Frankenstein L,Ehlermann P,Sack FU,Katus HA,Dengler TJ

    更新日期：2010-11-01 00:00:00

  • Right-lobe living-donor liver transplantation in adult patients with acute liver failure.

    abstract：BACKGROUND:Right-lobe living-donor liver transplantation (RLDLT) is an excellent option to reduce donor shortages for adult patients with acute liver failure (ALF). The aim of this study was to evaluate the etiologies and outcomes of 30 consecutive adult patients who underwent emergency RLDLT for ALF. METHODS:Between ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.10.056

    authors： Ates M,Hatipoglu S,Dirican A,Isik B,Ince V,Yilmaz M,Aydin C,Ara C,Kayaalp C,Yilmaz S

    更新日期：2013-06-01 00:00:00

  • Systemic vascular hemodynamics and transplanted kidney survival.

    abstract：INTRODUCTION:High blood pressure and arterial stiffness contribute independently to cardiovascular mortality in uremic patients. High blood pressure is an established risk factor for chronic allograft nephropathy, recently named interstitial fibrosis/tubular atrophy (IF/TA). We sought to assess whether heart afterload ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.014

    authors： Wystrychowski G,Kolonko A,Chudek J,Zukowska-Szczechowska E,Wiecek A,Grzeszczak W

    更新日期：2011-10-01 00:00:00

  • De novo malignancies after liver transplantation: incidence comparison with the Korean cancer registry.

    abstract：PURPOSE:De novo malignancy is not uncommon after liver transplantation (OLT). We have compared the incidence of novo malignancy following OLT with those among the general Korean population. METHODS:Between January 1998 and December 2008, 1952 adult OLT were performed, including 1714 living donor and 238 deceased donor...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.027

    authors： Park HW,Hwang S,Ahn CS,Kim KH,Moon DB,Ha TY,Song GW,Jung DH,Park GC,Namgoong JM,Yoon SY,Park CS,Park YH,Lee HJ,Lee SG

    更新日期：2012-04-01 00:00:00

  • Re-operation in pancreas transplantation.

    abstract：BACKGROUND:Surgical complications in pancreas transplantation are associated with increased morbidity and graft loss. The purpose of our study was to determine the frequency of re-operation in early and late postoperative of pancreas transplantation and its impact in relation to graft survival, patient survival, and ho...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.058

    authors： Cornejo-Carrasco CE,Fernández-Cruz L

    更新日期：2014-11-01 00:00:00

  • Porcine Transgenic, Acellular Material as an Alternative for Human Skin.

    abstract：:Although new therapeutic approaches for burn treatment have made progress, there is still need for efficient coverage of donor fields. Promising dressing for skin graft donor site should be biocompatible, attach easily to the wound bed, remain in place until donor site has renewed, and decrease morbidity at the site. ...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.transproceed.2020.01.125

    authors： Kitala D,Klama-Baryła A,Łabuś W,Kraut M,Glik J,Kawecki M,Joszko K,Gzik-Zroska B

    更新日期：2020-09-01 00:00:00

  • Stented Lich-Gregoir ureteroneocystostomy: case series report and cost-effectiveness analysis.

    abstract：UNLABELLED:Extravesical ureteroneocystostomy to reestablish urinary tract continuity in renal transplantation has been examined through a meta-analysis of more than 14,000 kidney transplants leading to the finding that stented anastomosis was associated with a lower urologic complication rate compared with nonstented a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.10.061

    authors： Mangus RS,Haag BW,Carter CB

    更新日期：2004-12-01 00:00:00

  • Gastroduodenal arterial reconstruction of the pancreaticoduodenal allograft.

    abstract：:Simultaneous procurement of the pancreas and liver necessitates division of vessels supplying both organs. The integrity of the pancreatic arterial supply appears to be related to surgical complications after pancreas transplantation. We have described herein three cases of gastroduodenal artery (GDA) reconstruction d...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2011.10.043

    authors： Li JQ,He ZJ,Si ZZ,Hu W,Li YN,Qi HZ

    更新日期：2011-12-01 00:00:00

  • Educational system for transplant coordinators in Poland: postgraduate studies at Warsaw Medical University; 2 years of experience.

    abstract：:Donor hospital transplant coordinators play crucial roles in the donation process. There are only a few coordinators in Poland, while there are about 400 hospitals with intensive care units (ICU). Coordinators must be professionals in medical sciences, clinical psychology, law, organization, management, and statistics...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.005

    authors： Czerwiński J,Jakubowska-Winecka A,Becler R,Kubik T,Milecka A,Sekta S,Pabisiak K,Malanowski P,Rowinński W

    更新日期：2009-10-01 00:00:00

  • Liver Transplantation for Budd-Chiari Syndrome With Large Solitary Focal Nodular Hyperplasia of the Liver in a Patient With Essential Thrombocythemia: Case Report. [Corrected].

    abstract：:Budd-Chiari syndrome is a rare condition caused by interrupted hepatic venous outflow in the hepatic veins, inferior vena cava, or right atrium. Reports from the literature have delineated on focal nodular hyperplasia (FNH)-like lesions in association with Budd-Chiari Syndrome. To our knowledge, there are no reports a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.05.008

    authors： Alnajjar A,Al-Hussaini H,Al Sebayel M,Al-Kattan W,Elsiesy H

    更新日期：2015-09-01 00:00:00

  • Anxiety and depression levels of patients undergoing liver transplantation and their need for training.

    abstract：:The purpose of this research was to determine the levels of anxiety and depression and the need for training of patients who had undergone liver transplantation. This descriptive research included patients who had undergone liver transplantation at least 1 month prior and had follow-up between June and November 2006. ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.11.012

    authors： Pelgur H,Atak N,Kose K

    更新日期：2009-06-01 00:00:00

  • The role of cysteinyl-LT(1)receptor (CysLT(1)R) in renal ischemia-reperfusion injury.

    abstract：:The pathogenesis of ischemia-reperfusion (I/R) injury is known to involve cytokines and particularly surface adhesion molecules, the expression of which initiates the attachment of inflammatory cells. Renal I/R injury, a clinically important problem, is an invariable consequence of renal transplantation. The problem b...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.153

    authors： Matsuyama M,Funao K,Chargui J,Touraine JL,Nakatani T,Yoshimura R

    更新日期：2009-01-01 00:00:00

  • Global cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation.

    abstract：UNLABELLED:A primary reason to eliminate corticosteroids from immunosuppressive regimens in solid organ transplant recipients is improved cardiovascular risk profiles. Although a number of studies have documented that corticosteroid withdrawal (CSWD) regimens reduce hypertension, hyperlipidemia, diabetes, and weight ga...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.01.060

    authors： Rogers CC,Alloway RR,Boardman R,Trofe J,Hanaway MJ,Alexander JW,Roy-Chaudhury P,Buell JF,Thomas M,Susskind B,Woodle ES

    更新日期：2005-03-01 00:00:00

  • Effects of Granulocyte and Monocyte Adsorptive Apheresis in Renal Transplantation Recipients With Concomitant Cytomegalovirus Infection.

    abstract：BACKGROUND:Granulocyte and monocyte adsorptive apheresis (GMAA) is widely used as a treatment for active ulcerative colitis (UC) in Japan. Much attention has been paid to the possibility of GMAA for the treatment and control of cytomegalovirus (CMV) reactivation in patients with refractory UC and concomitant CMV infect...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.127

    authors： Naganuma T,Takemoto Y,Iwai T,Kuwabara N,Uchida J,Nakatani T,Kitamura K,Masuda A,Ohmori K,Matsuura M,Nakase H

    更新日期：2016-04-01 00:00:00

  • Transplantation of organs: natural limitations, possible solutions--a UK perspective.

    abstract：:While the outcome following organ transplantation in the United Kingdom has never been better, the waiting list has never been longer and the organ shortage is now the most pressing issue. UK Transplant has invested in four initiatives to promote donor and transplant numbers: coordinating the coordinators, establishin...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00127-1

    authors： Rudge CJ

    更新日期：2003-05-01 00:00:00

  • Two-hour post-dose cyclosporine levels in renal transplantation in Argentina: a cost-effective strategy for reducing acute rejection.

    abstract：UNLABELLED:Monitoring of cyclosporine (microemulsion CsA) at 2 hours post-dose (C2), a measure of absorption and exposure, appears superior to trough (C0) monitoring for prediction of rejection risk. The purpose of this study was to determine whether C2 was cost-effective compared to C0 in Argentina. METHODS:A predict...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.188

    authors： Balshaw R,Machnicki G,Carreño CA,Toselli L,Otero A,Keown PA

    更新日期：2005-03-01 00:00:00

  • Multidetector computed tomography angiography in the evaluation of potential living donors for liver transplantation: single-center experience in China.

    abstract：OBJECTIVE:To evaluate relevant arterial, hepatic, and portal venous anatomy using multidetector computed tomography (CT) angiography in potential living liver donors at a single liver transplantation center in China. METHODS:One hundred two consecutive potential liver donors underwent CT angiography in the arterial, p...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.031

    authors： Zhuang ZG,Qian LJ,Gong HX,Zhou Y,Chai WM,Li QG,Xu JR

    更新日期：2008-10-01 00:00:00

  • Impact of the conversion of the immunosuppressive regimen from prograf to advagraf or to sirolimus in long-term stable liver transplant recipients: indications, safety, and outcome.

    abstract：BACKGROUND:Compliance problems have arisen due to the twice a day administration of calcineurin inhibitors (CNI). We examined the safety, indications, and efficacy in terms of graft and patient survivals after conversion from tacrolimus to sirolimus or advagraf. PATIENTS AND METHODS:Between January 2006 and December 2...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.09.015

    authors： Perrakis A,Schwarz K,Yedibela S,Croner RS,Hohenberger W,Müller V

    更新日期：2011-12-01 00:00:00

  • The outcome of induction therapy with monoclonal antibodies in kidney transplantation among Iranian patients: a prospective study.

    abstract：INTRODUCTION:The administration of interlukin-2 receptor antagonists for induction therapy has reduced the incidence of acute rejection episodes in kidney transplantation. Although some studies have investigated the efficacy of these monoclonal antibodies, there is little experience among Iranian kidney transplant reci...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2009.06.180

    authors： Naderi GH,Mehraban D,Ganji MR,Jafarpouriani M,Latif AH

    更新日期：2009-09-01 00:00:00

  • Laparoscopic organ retrieval for living donor liver transplantation does not prevent graft injury.

    abstract：:The cause of transplant failure may be difficult to define. However, organ retrieval before preservation and transplantation is an important factor. Organ manipulation during harvesting, which is inevitable with most techniques, leads to injury upon reperfusion including microcirculatory disturbances. Recently, laparo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.020

    authors： Schemmer P,Barro-Bejarano M,Mehrabi A,Gebhard MM,Kraus T,Büchler MW,Gutt CN

    更新日期：2005-04-01 00:00:00

  • Nonmarginal-donor duodenal ulcers caused by rejection after simultaneous pancreas and kidney transplantation: a case report.

    abstract：OBJECTIVE:Pancreas transplantation has been associated with the highest surgical complication rate among routinely performed organ transplant procedures. Complications can be caused not only from the pancreas itself but also from the simultaneously transplanted duodenum: gastrointestinal bleeding, duodenal ulcer, pseud...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.09.094

    authors： Miyagi S,Sekiguchi S,Kawagishi N,Akamatsu Y,Satoh K,Takeda I,Fujimori K,Satomi S

    更新日期：2011-11-01 00:00:00

  • Successful Urgent Living Donor Liver Transplantation for Massive Liver Necrosis Accompanied by Nonocclusive Mesenteric Ischemia in a Biliary Atresia Infant: A Case Report.

    abstract：BACKGROUND:Treatment options for patients presenting with life-threatening splanchnic ischemia, including that of the intestine and liver, could previously only receive salvage surgery and attempted medical revascularization. We propose that urgent liver transplantation (LT) for acute liver failure (ALF) due to massive...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.010

    authors： Yoshimaru K,Matsuura T,Yanagi Y,Takahashi Y,Kohashi K,Kaku N,Oda Y,Ohga S,Taguchi T

    更新日期：2020-11-01 00:00:00

  • Association Safety of Liver Preservation Solutions at the State University of Campinas From 2010 to 2014.

    abstract：:The probable reason for mixing solutions during the harvesting procedure is due to the presence of multiple transplant teams that have their own solution usage tradition. Despite numerous studies comparing the efficacy of different preservation solutions, there is no study addressing the associating solution and if th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.01.058

    authors： Reigada CHP,de Ataide EC,Mattosinho TDAP,Costa LBE,Escanhoela CA,Boin IFSF

    更新日期：2017-05-01 00:00:00

  • Risk of viral transmission via bone marrow progenitor cells versus umbilical cord blood hematopoietic stem cells in bone marrow transplantation.

    abstract：:Hematopoietic stem cell transplantation (HSCT) is the treatment of choice for children and certain adults with malignant and nonmalignant hematologic disease. Since viral infections are the major problem, this study examined those that might potentially be transmitted to HSCT recipients via bone marrow (BM) versus umb...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.07.007

    authors： Behzad-Behbahani A,Pouransari R,Tabei SZ,Rahiminejad MS,Robati M,Yaghobi R,Nourani H,Ramzi MM,Farhadi-Andarabi A,Mojiri A,Rahsaz M,Banihashemi M,Zare N

    更新日期：2005-09-01 00:00:00

  • Prophylactic Use of Laser Light and Methylene Blue on Ischemia and Liver Reperfusion Injury.

    abstract：OBJECTIVE:This study aimed to evaluate the effect of hepatic preconditioning with laser light in the presence of methylene blue (MB) in the liver ischemia-reperfusion injury process. METHOD:Forty male Wistar rats were divided into 8 experimental groups (n = 5). Saline (.5 mL) or MB (15 mg/kg) was injected intravenousl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.02.018

    authors： Albuquerque FP,Laureano E,Jordani-Gomes MC,Fina CF,Vanni C,Mente ED,Vollet Filho JD,Bagnato VS,Dálbuquerque LAC,Évora PRB,Castro E Silva O

    更新日期：2019-06-01 00:00:00

  • Robot-Assisted Radical Prostatectomy in a Post-Kidney Transplant Patient: An Initial Case Report in China.

    abstract：OBJECTIVE:Our aim was to evaluate the general applicability, feasibility, and safety of robot-assisted radical prostatectomy (RARP) in Chinese renal allograft patients for prostate cancer removal. PATIENTS AND METHODS:A 62-year-old patient diagnosed as having biopsy-proven localized prostate cancer in March 2016 who h...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.09.015

    authors： Fang Y,Chen Z,Juan L,Feng Z,Cao J,Zhou B,Huang Y,Cen J,Lu J,Liang Y,Wei J,Luo J,Chen W

    更新日期：2018-12-01 00:00:00