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Short- and Long-Term Outcomes of Live Donor Renal Allografts From Older and Younger Donors.

Abstract：

BACKGROUND:The rising demand for living renal donors has led to the recruitment of older donors. Findings vary, but these grafts appear to survive as long as grafts from standard criteria deceased and expanded criteria deceased donors. We investigated the effects of donor age ≥65 years and the presence or absence of donor antihypertensive therapy on patient condition 1 year after transplantation, and retrospectively examined 1-year (273 patients), 3-year (217 patients), and 5-year (140 patients) patient and graft survival. METHODS:We divided 273 donor-recipient pairs into Group Y (donor age <65 years, n = 224) and Group O (donor age ≥65 years, n = 49). Group O was subdivided into donors receiving treatment for hypertension (subgroup O-1, n = 16) and those not receiving treatment for hypertension (subgroup O-2, n = 33). We compared results of 1 hour post-transplant biopsies and looked at a small number of 1 year post-transplant biopsies. RESULTS:Although a significantly larger percentage of recipients from younger donors were undergoing preemptive transplantation, and the incidence of arteriosclerosis was significantly higher in the Group O kidneys, there were no significant differences between the 2 groups in terms of patient or graft survival at 1, 3, or 5 years; serum creatinine levels; or number of episodes of acute rejection. The presence or absence of donor antihypertensive treatment had no effect. CONCLUSIONS:We found that donor age ≥65, with or without antihypertensive treatment, had no effect on graft or patient survival.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Matsuyama T,Ushigome H,Osaka M,Masuda K,Harada S,Nakamura T,Nobori S,Iida T,Yoshimura N

doi

10.1016/j.transproceed.2018.08.046

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3228-3231

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)31189-8

journal_volume

50

pub_type

杂志文章

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