Abstract:
:In this short review I show how cyclosporine fits into the broader picture of immunosuppression for organ allografting. Before cyclosporine there were some good results, particularly in kidney grafting, but also a failure rate of 50% of grafts by 1 year. Cyclosporine changed the graft survival of 1 year to 80%, although at 10 years the graft survival was little different from patients treated with azathioprine and steroids. Nevertheless, many patients achieved good function in their kidneys when treated with cyclosporine; these patients would have lost the kidneys under the old regimen. The cause of the late failure in patients treated with cyclosporine was predominantly nephrotoxicity due to the calcineurine inhibition, damaging the kidneys. Now that this is better understood and new drugs are available, many regimens have been tried but cyclosporine remains an important tool for the clinician in the treatment of patients with organ allografts.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Calne Rdoi
10.1016/j.transproceed.2004.01.042subject
Has Abstractpub_date
2004-03-01 00:00:00pages
13S-15Sissue
2 Suppleissn
0041-1345issn
1873-2623pii
S0041134504000247journal_volume
36pub_type
杂志文章,评审abstract:BACKGROUND:In new organ allocation policy, patients with hepatocellular carcinoma (HCC) experience a 6-month delay in being granted Model for End-Stage Liver Disease exception points. However, it may not be fair for patients at risk of early progression of HCC. METHODS:All patients who were diagnosed as United Network...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2018.08.021
更新日期:2018-12-01 00:00:00
abstract:UNLABELLED:We have previously reported that tolerance to class I disparate lung allografts in miniature swine could be induced using an intensive 12-day course of tacrolimus and that pretransplant sensitization with immunogenic MHC class I allopeptides failed to block the induction of tolerance. We also have previously...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2006.10.064
更新日期:2006-12-01 00:00:00
abstract::Renal function after heart transplantation (HTx) typically follows a biphasic pattern and an initial decay within 1 to 2 years. Trajectory of renal function after HTx is less reported, especially in Asia. The aims of this cohort study were to describe the changes in HTx recipients' serum creatinine and estimated glome...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2018.02.196
更新日期:2018-11-01 00:00:00
abstract::Pancreas and kidney transplantation is the treatment of choice for patients with type 1 diabetes mellitus and terminal renal insufficiency. Herein we have presented a series of 35 patients transplanted between 2002 and 2009 including periods before and after 2007 divided based on introduction of some technical aspects...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.12.001
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:In this open-label multicenter study, 205 simultaneous pancreas-kidney (SPK) transplant recipients between 1998 and 2000 were randomly assigned to tacrolimus or cyclosporine-microemulsion (ME). All patients received concomitant rATG induction therapy, mycophenolate mofetil and short-term corticosteroids. W...
journal_title:Transplantation proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.transproceed.2005.05.021
更新日期:2005-07-01 00:00:00
abstract::Diarrhea is a frequent complication of small bowel transplantation in patients and experimental models. Although there are many potential causes, the underlying basis for most are not fully understood. Improved therapeutic approaches will come about through better understanding of mechanisms of bowel adaptation and re...
journal_title:Transplantation proceedings
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Induction therapy is used to reduce the incidence of graft rejection and delayed graft function. Thymoglobulin is the most used inductor agent in deceased donor kidney transplantation due to its lower rejection and delayed graft function rates. METHODS:Retrospective study of patients who underwent deceased ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2016.02.018
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify predictors of overall survival (OS), disease-free survival (DFS), and recurrence in a cohort of 151 patients with hepatocellular carcinoma (HCC) and cirrhosis who were treated by liver transplantation (LT). PATIENTS AND METHODS:A retrospective database of patients under...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2016.04.002
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to analyze the role of interventional ultrasound in the treatment of nonvascular complications in liver transplant recipients. METHODS:Between August 1996 and May 2003, we performed 426 OLTs in 394 patients, 287 men (73%) and 107 women (27%), mean age of 50 +/- 9.5 years (range...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2004.02.037
更新日期:2004-04-01 00:00:00
abstract::The Prometheus system is a plasma filtration treatment coupling adsorption and hemodialysis (FPSA) aimed to blood purification in liver failure. After separation through an albumin-permeable membrane, plasma enters a secondary circuit where protein-bound toxic substances are removed by two adsorbers; p01, a neutral re...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2006.02.017
更新日期:2006-05-01 00:00:00
abstract::The cause of transplant failure may be difficult to define. However, organ retrieval before preservation and transplantation is an important factor. Organ manipulation during harvesting, which is inevitable with most techniques, leads to injury upon reperfusion including microcirculatory disturbances. Recently, laparo...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2004.09.020
更新日期:2005-04-01 00:00:00
abstract:AIM:To evaluate organ procurement efficiency at Hospital Clinic of Barcelona (HCP), a University Hospital, in 2000 and 2003 compared with other Catalan, other Spanish, and American (US) results. METHODS:Efficacy rate of the donor procurement was calculated per million population per year (pmp/y). Efficacy rate in kidn...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2005.08.052
更新日期:2005-11-01 00:00:00
abstract::Ascites is a common clinical condition during right heart failure. In this short report we have presented a patient with massive ascites due to right heart failure after cardiac transplantation who was previously operated for Ebstein's anomaly and pulmonary stenosis as well as mitral and tricuspid valve repairs. Right...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.11.035
更新日期:2008-01-01 00:00:00
abstract::The Italian Gate to Europe (IGE) was established in April 2005 to supply a single national coordinating center for the exchange of organs and patients with the rest of Europe. When an organ is offered from Italy, the IGE ascribes it to the first foreign organization that accepts it on a first-come, first-served basis....
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.05.071
更新日期:2007-07-01 00:00:00
abstract::We performed a retrospective cohort study between 2002 and 2014 to compare liver transplantation outcomes between recipients of grafts from donors older than and younger than the age of 80 years. Numerical variables were compared with the Student t test when their distribution was normal and the Mann-Whitney test when...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2015.10.004
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Laparoscopic donor nephrectomy has become the preferred method for live kidney donation in many centers. Herein we have reported on donor-related quality of life (QoL) and social state after laparoscopic hand-assisted nephrectomy (HALDN) for living kidney donation. PATIENTS AND METHODS:Between December, 200...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2010.01.078
更新日期:2010-06-01 00:00:00
abstract::Herein, we report the case of a 52-year-old man with a spermatic cord liposarcoma that developed 4 years after renal transplantation. The patient was admitted with a diagnosis of inguinal hernia. During surgical exploration, a solid mass was found arising from the spermatic cord. Histologic analysis demonstrated a wel...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2010.03.043
更新日期:2010-05-01 00:00:00
abstract:AIMS:The aim of this project was to identify the dark-recovery experiences (DRE) that adult heart transplant recipients (AHTRs) perceived as causing the most suffering after heart transplantation (HT). In artition, we sought to explore the stage-specific difficulties, coping strategies, and helpers for transplant recip...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2010.03.021
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:To develop a logistic regression model capable of predicting health-related quality of life (HRQOL) among kidney transplant recipients and determine its accuracy. METHODS:Three groups of patients were selected: 70 healthy controls, 136 kidney transplant patients as a derivation set, and another 110 kidney t...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.04.004
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:Kidney transplantation from marginal donors is an important solution for organ shortage problems. In this study, we evaluated the safety and effectiveness of living kidney transplantation from marginal donors at our hospitals. METHODS:Between June 2006 and April 2019, 107 patients underwent living kidney ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2020.01.157
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:One common complication after kidney transplantation is a lymphocele. The aim of our work was an analysis of incidence of lymphocele and the effectiveness of minimal invasive methods in the management of this complication. MATERIALS AND METHODS:The examined group was consisted of 158 patients (68 female and...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.09.045
更新日期:2009-10-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title:Transplantation proceedings
pub_type: 撤回出版物
doi:10.1016/j.transproceed.2019.02.036
更新日期:2020-07-01 00:00:00
abstract::All over the world, transplant teams are looking for ways to increase and improve the donor pool. Non-heart-beating donation may increase the number of donors, even if some technical, logistical, and emotional problems are still encountered. The results obtained by our team should stimulate other centers to implement ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.08.028
更新日期:2007-10-01 00:00:00
abstract::Valganciclovir is an l-valyl ester pro-drug of ganciclovir that was initially used to treat cytomegalovirus (CMV)-associated retinitis in patients with human immunodeficiency virus. Currently, it is also indicated for the prevention of CMV disease in solid-organ transplantation. It is primarily eliminated via the kidn...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.02.093
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The effectiveness of everolimus (EVR) for ABO-incompatible (ABOi) kidney transplantation is unknown. We evaluated outcomes of conversion from steroid to EVR in ABOi kidney transplant recipients. METHODS:We performed a retrospective observational cohort study of 33 de novo consecutive adult ABOi living donor...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2018.01.028
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:After significant improvement of the family consent rate to organ donation (OD) in recent years, owing to an increase in cultural activities and social awareness, a plateau has been reached. This study was performed to detect the causes for this plateau. METHODS:We reviewed exact causes of family refusal ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2017.11.021
更新日期:2018-01-01 00:00:00
abstract::We herein provide an update on two bilateral hand and one bilateral forearm transplants with emphasis on immunosuppression (IS), function, morphology, and graft vascular changes at 8 years and 2 years after bilateral hand and 5 years after bilateral forearm transplantation. Between March 2000 and May 2006, three patie...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.01.013
更新日期:2009-03-01 00:00:00
abstract::The present study demonstrated the feasibility of monitoring nitric oxide (NO) and pO2 levels under ischemic conditions associated with small bowel ischemia/reperfusion (I/R) injury through the use of selective electrodes for NO and oxygen molecules. NO levels gradually increased during ischemia. When reperfusion was ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.08.090
更新日期:2007-12-01 00:00:00
abstract::Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection episodes (ARE) and potential tolerogenic properties. We analyzed the clinical outcomes and effects on p...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2008.03.066
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:There is a considerable transplant organ deficit. To offset the organ shortage, living donation is being encouraged. Young persons form a sector of the population in whom early awareness is important to encourage favorable attitudes toward donation. Teachers play important roles in education and in generatin...
journal_title:Transplantation proceedings
pub_type: 杂志文章,多中心研究
doi:10.1016/j.transproceed.2010.05.076
更新日期:2010-10-01 00:00:00