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Cytomegalovirus infection in simultaneous pancreas-kidney transplantation.

Abstract：

INTRODUCTION:In this open-label multicenter study, 205 simultaneous pancreas-kidney (SPK) transplant recipients between 1998 and 2000 were randomly assigned to tacrolimus or cyclosporine-microemulsion (ME). All patients received concomitant rATG induction therapy, mycophenolate mofetil and short-term corticosteroids. We report the 3-year data related to the occurrence, severity and effect of cytomegalovirus (CMV) infections. The type of CMV prophylaxis and treatment was at the discretion of the investigator. RESULTS:The overall incidence of CMV infection was 34% with no difference in incidence between the tacrolimus and cyclosporine-ME treatment arms. Statistically significant fewer CMV infections occurred among patients who received ganciclovir (22%) than those who did not receive prophylaxis (42%; P = .0075) or were treated with acyclovir (43%; P = .0066). The CMV infection rate according to donor recipient CMV serological status was: D-/R- group 11%, which was lower than the D-/R+ group at 40% (P = .0035), the D+/R+ group at 37% (P = .0024), or the D+/R- group at 52% (P = .00001). Among the last three groups, the infection rate was lower in patients on ganciclovir than those with no prophylaxis or on acyclovir (22% vs 64%; P = .00001). The incidence of acute rejection episodes was higher among patients without ganciclovir prophylaxis. No difference was observed in actuarial patient, kidney, or pancreas survival rates between patients with versus without infection. CONCLUSIONS:Ganciclovir prophylaxis effectively prevented CMV infection in SPK transplant recipients, especially in higher risk groups. An effect of CMV prophylaxis on the incidence of rejection is possible.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Malaise J,Ricart MJ,Moreno A,Crespo M,Fernández-Cruz L,Van Ophem D,Squifflet JP,EUROSPK Study Group.

doi

10.1016/j.transproceed.2005.05.021

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

2848-50

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00560-9

journal_volume

37

pub_type

杂志文章,多中心研究,随机对照试验

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