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Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report.

Abstract：

:Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Frilling A,Giele H,Vrakas G,Reddy S,Macedo R,Al-Nahhas A,Wasan H,Clift AK,Gondolesi GE,Vianna RM,Friend P,Vaidya A

doi

10.1016/j.transproceed.2015.01.007

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

858-62

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00083-4

journal_volume

47

pub_type

杂志文章

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