Conversion to rapamycin in a renal transplant patient with von Hippel-Lindau disease: encouraging results-a case report.

Abstract:

:von Hippel-Lindau (VHL) disease is a genetic syndrome based on an abnormality of the VHL gene located on the short arm of chromosome 3. Clinically, it presents as multiple tumors at several levels. The VHL gene product (pVHL) acts as a tumor-suppressing protein. In conditions of hypoxia it leads to an increase in several growth factor levels. mTOR inhibitors have proved to have dual properties: immunosuppressive and antitumor effects. Herein we have presented a case in which conversion to sirolimus improved graft function and also caused regression of retinal angioblastomas.

journal_name

Transplant Proc

authors

Henriquez F,Gallego R,Oliva E,Silva D,Vega N

doi

10.1016/j.transproceed.2008.08.086

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

3115-6

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)01164-0

journal_volume

40

pub_type

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