Single-Center Experience of Living Donor Liver Transplantation for Patients With Secondary Biliary Cirrhosis.

Abstract:

BACKGROUND:Secondary biliary cirrhosis (SBC) represents a unique form of cirrhosis that develops in the liver secondary to persistent biliary obstruction. This study aimed to review the living donor liver transplants (LDLTs) performed at our center for patients with SBC and end-stage liver disease and to share the perioperative strategies undertaken to achieve satisfactory outcomes. METHODS:The medical records of 29 patients who underwent LDLT for SBC between December 1994 and July 2018 at the Asan Medical Center (Seoul, South Korea) were retrospectively reviewed. Their clinical data were extracted and statistically analyzed. Survival curves were computed. RESULTS:The perioperative and in-hospital morbidity rates were 72.4% and 10.3%, respectively. The overall mean recipient follow-up was 80.0 (SD, 66.4) months (range, 0.8-246.8 months). Patient survival rates after 1, 3, 5, and 10 years after transplant were 82.8%, 79.3%, 79.3%, and 79.3%, respectively. For liver grafts, the survival rates were 82.8%, 75.8%, 75.8%, and 75.8% at 1, 3, 5, and 10 years, respectively. CONCLUSIONS:LDLT is potentially a final lifesaving resort for patients with SBC with portal hypertension. However, considering the difficulty of surgery and perioperative management, LDLT should be performed by experienced transplant surgeons in a center where a multidisciplinary approach is possible.

journal_name

Transplant Proc

authors

Chang JG,Yoon YI,Lee SG,Hwang S,Kim KH,Ahn CS,Moon DB,Ha TY,Song GW,Jung DH,Park GC,Park JI

doi

10.1016/j.transproceed.2020.10.044

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

98-103

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(20)32886-4

journal_volume

53

pub_type

杂志文章
  • Laparoscopic approach for down-staging in hepatocellular carcinoma patients who are candidates for liver transplantation.

    abstract:INTRODUCTION:The aim of this study was to assess the impact of laparoscopic thermoablation (LTA) and laparoscopic resection (LR) as neoadjuvant therapy before orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). METHODS:From June 2005 to November 2010, 50 consecutive patients affected by HCC with...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.07.014

    authors: Casaccia M,Andorno E,Santori G,Fontana I,Varotti G,Ferrari C,Ertreo M,Valente U

    更新日期:2013-09-01 00:00:00

  • Hyperdynamic circulation in acute liver failure: reperfusion syndrome and outcome following liver transplantation.

    abstract:BACKGROUND/AIMS:Liver transplantation (OLT) is a valid therapeutic option for patients with fulminant hepatic failure (FHF). The most critical phase during OLT is considered to be graft reperfusion, where in large changes in patient homeostasis occur. The aims of the present study were to evaluate the hemodynamic and c...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.03.097

    authors: Siniscalchi A,Dante A,Spedicato S,Riganello L,Zanoni A,Cimatti M,Pierucci E,Bernardi E,Miklosova Z,Moretti C,Faenza S

    更新日期:2010-05-01 00:00:00

  • Nutritional outcomes following pediatric intestinal transplantation.

    abstract:BACKGROUND:This study sought to describe the long-term nutritional outcomes of children after intestinal transplant (SBT). METHODS:Between 1991 and March 2005, 30 children received 33 SBT at a single center. Eligibility criteria included patient and graft survival >6 months. Weight, height, albumin, prealbumin, zinc (...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.05.051

    authors: Venick RS,Farmer DG,Saikali D,Gordon S,Colangelo J,Reyen L,McDiarmid SV,Vargas JH,Ament ME,Busuttil RW

    更新日期:2006-07-01 00:00:00

  • Management of uncommon hernias in cirrhotic patients.

    abstract:BACKGROUND:Abdominal hernias are a common disease among cirrhotic patients, because of malnutrition and persistently high intra-abdominal pressure due to ascites. When tense ascites is present, life-threatening complications are likely to occur. In such cases, the morbidity and mortality rates are high. OBJECTIVE:We d...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.02.090

    authors: Andraus W,Sepulveda A,Pinheiro RS,Teixeira AR,D'Albuquerque LA

    更新日期:2010-06-01 00:00:00

  • The modification of diet in renal disease and chronic kidney disease epidemiology collaboration formulas versus measured or estimated creatinine clearance in kidney transplant recipients.

    abstract:BACKGROUND:Estimation of glomerular filtration rate (eGFR) after renal transplantation is performed with the use of methods that are standardized for a population of nontransplantation patients with chronic kidney disease. The aim of the study was to compare the performance of GFR estimation formulas in renal transplan...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.09.009

    authors: Chrobak L,Dębska-Ślizień A,Jankowska M,Sledziński Z,Rutkowski B

    更新日期:2014-10-01 00:00:00

  • Navigating Kidney Transplantation in the Early Phase of Coronavirus Disease 2019: Screening Patients With Reverse Transcriptase Polymerase Chain Reaction and Low-Radiation-Dose Chest Computed Tomography.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic of 2020 changed organ transplantation. All elective cases at our institution were postponed for approximately 3 months. Centers for Medicare and Medicaid Services considers organ transplant surgery a Tier 3b case, along with other high acuity procedures, recom...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2021.01.001

    authors: Butt FK,Julian K,Kadry Z,Jain A

    更新日期:2021-01-09 00:00:00

  • Contrast-enhanced ultrasonography in the early period after kidney transplantation predicts long-term allograft function.

    abstract:INTRODUCTION:Real-time contrast-enhanced sonography (CES) can assess microvascular tissue perfusion using gas-filled microbubbles. The purpose of the study was to evaluate the feasibility of early CES in predicting long-term kidney allograft function in comparison to color Doppler ultrasonography (CDUS). METHODS:We pr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.04.013

    authors: Schwenger V,Hankel V,Seckinger J,Macher-Göppinger S,Morath C,Zeisbrich M,Zeier M,Kihm LP

    更新日期:2014-12-01 00:00:00

  • Candida-associated denture stomatitis in patients after immunosuppression therapy.

    abstract::Patients who undergo kidney or liver transplantation receive long-lasting immunosuppressive therapy. The resultant unfavorable symptoms result from immune deficiency and the side effects of the medications. The aim of this study was to establish the frequency and intensity of denture stomatitis and oral candidiasis am...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.12.078

    authors: Golecka M,Ołdakowska-Jedynak U,Mierzwińska-Nastalska E,Adamczyk-Sosińska E

    更新日期:2006-01-01 00:00:00

  • Knowledge and Willingness to Donate Kidneys for Transplantation in Ghana: A Cross-Sectional Survey.

    abstract:BACKGROUND:The main treatment modalities for chronic kidney disease (CKD) are dialysis and kidney transplantation. While kidney transplantation provides better survival and quality of life outcomes, it is a new treatment option in Ghana. Finding kidney donors for transplant may be a major challenge due to varied views ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.02.165

    authors: Boima V,Ganu V,Yorke E,Dey D,Amissah-Arthur MB,Agyabeng K,Yawson A,Lartey M,Mate-Kole CC

    更新日期:2020-12-01 00:00:00

  • Prophylactic use of low-dose, on-demand, intramuscular hepatitis B immunoglobulin and lamivudine after liver transplantation.

    abstract::The combination of hepatitis B immunoglobulin (HBIG) and antivirals (nucleos[t]ide analogs) has extended the applicability of orthotopic liver transplantation (OLT) for patients with hepatitis B virus (HBV)-related liver disease. However, HBIG administrations have an extremely high cost. Herein, we evaluated our resul...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.12.063

    authors: Karademir S,Astarcioğlu H,Akarsu M,Ozkardesler S,Ozzeybek D,Sayiner A,Akan M,Tankurt E,Astarcioğlu I

    更新日期:2006-03-01 00:00:00

  • Pancreas Transplantation: Small-Center Experience in Type 1 Diabetes Mellitus in a High-Incidence Region.

    abstract:BACKGROUND:Pancreas transplantation (PT) is the best option of care for patients with type I diabetes mellitus (T1DM). METHODS:From July 2005 to September 2014, we performed 27 PT from deceased donors (24 simultaneous pancreas-kidney transplantations [SPKT] and 3 pancreas transplantations alone) in a region with a hig...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.11.070

    authors: Tondolo V,Manunza R,Pellegrino RA,Zamboni F

    更新日期:2015-09-01 00:00:00

  • Very low-grade proteinuria at 3 months posttransplantation is an earlier marker of graft survival.

    abstract::Proteinuria is an early finding that appears in the first 3 months after transplantation in half of patients. Frequently, it is very low grade (VLP; <0.5 g/24 h). The aim of this study was to analyze the risk factors and prognostic significance of VLP at 3 months posttransplantation, which was maintained for the first...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.06.137

    authors: Sancho Calabuig A,Pallardó Mateu LM,Avila Bernabeu AI,Gavela Martínez E,Beltrán Catalán S,Crespo Albiach JF

    更新日期:2009-07-01 00:00:00

  • Histologic studies of islets of Langerhans in transplanted pancreata from marginal donors in Japan.

    abstract::The serious shortage of brain-dead donors leads to the use of pancreata from marginal donors, including cardiac death in Japan. We studied the islet histology of pancreas graft biopsies to investigate the adequacy of using pancreata from marginal donors. Pancreas allograft biopsy was performed originally to diagnose a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.02.080

    authors: Ishida-Oku M,Iwase M,Sugitani A,Masutani K,Kitada H,Tanaka M,Iida M

    更新日期:2010-06-01 00:00:00

  • Robot-Assisted Radical Cystectomy With Orthotopic Neobladder as a Urinary Diversion for a Kidney Transplant Recipient: A Case Report.

    abstract:BACKGROUND:A higher prevalence of bladder cancer is reported in solid organ recipients, and advanced cancer requires radical cystectomy combined with urinary diversion. Surgery is technically challenging in kidney transplant recipients because of urinary tract abnormalities. Here, we describe the use of a robot-assiste...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.12.002

    authors: Ishiyama Y,Yoshida K,Iizuka J,Unagami K,Hashimoto K,Moriyama I,Unagami K,Takagi T,Kakuta Y,Okumi M,Kondo T,Ishida H,Tanabe K

    更新日期:2020-03-01 00:00:00

  • Beta-2-microglobulin level predicts outcome following autologous hematopoietic stem cell transplantation in patients with multiple myeloma.

    abstract::Despite the widespread use of high-dose therapy combined with autologous hematopoietic stem cell transplantation (autoHSCT), the outcomes of multiple myeloma (MM) treatment remain variable. The aim of this study was to define pretransplantation factors that influence outcomes following autoHSCT in patients with MM. Ei...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.08.052

    authors: Stella-Holowiecka B,Czerw T,Holowiecka-Goral A,Giebel S,Wojnar J,Holowiecki J

    更新日期:2007-11-01 00:00:00

  • Excellent results of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids in renal transplant recipients--4-year results.

    abstract:BACKGROUND:Mizoribine (MZR) at 3 mg/kg/d shows less potent immunosuppressive effects, but high-dose MZR (6 mg/kg/d) was effective and safe in a 2-year study in conjunction with a regimen of cyclosporine (CsA), basiliximab, and corticosteroids. METHODS:We compared 40 living-related kidney recipients administered MZR (6...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.01.055

    authors: Yoshimura N,Ushigome H,Nobori S,Suzuki T,Sakai K,Koshino K,Okajima H,Okamoto M

    更新日期:2013-05-01 00:00:00

  • Body image in kidney transplantation.

    abstract:INTRODUCTION:Psychologic disturbances are becoming more common in kidney transplantation, owing to effects of immunosuppressive therapy. In this study, we explored the incidence and specifity of psychopathology among kidney transplant patients. Twenty kidney transplant recipients underwent the Machover Draw-A-person te...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.03.071

    authors: De Pasquale C,Pistorio ML,Sorbello M,Parrinello L,Corona D,Gagliano M,Giuffrida G,Giaquinta A,Sinagra N,Zerbo D,Veroux P,Veroux M

    更新日期:2010-05-01 00:00:00

  • First living related kidney transplantation results in excellent outcomes for small children.

    abstract:OBJECTIVE:The aim of this study was to evaluated the outcomes of living related kidney transplantation in small children. MATERIALS AND METHODS:Ten pediatric patients with body weights less than 10 kg received parental kidney transplants (five mothers and five fathers). An intra-abdominal approach was used in nine chi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.06.095

    authors: Aikawa A,Arai K,Kawamura T,Sugiyama K,Muramatsu M,Itabashi Y,Ohara T,Motoyama O,Hasegawa A

    更新日期:2005-09-01 00:00:00

  • Factors affecting graft survival after living donor liver transplantation.

    abstract::Living donor liver transplantation (LDLT) has been considered as an alternative option to resolve the shortage of cadaveric donor organs, despite the ethical aspects of the donor procedure. The objective of this study was to analyze the risk factors affecting graft survival in LDLT. From June 1996 to December 2002, 14...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.08.073

    authors: Lee DS,Gil WH,Lee HH,Lee KW,Lee SK,Kim SJ,Choi SH,Heo JS,Hyon WS,Kim GS,Paik SW,Koh KC,Joh JW

    更新日期:2004-10-01 00:00:00

  • Correlation between the kinetics of CD3+ chimerism and the incidence of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation.

    abstract:INTRODUCTION:Graft-versus-host disease (GvHD) remains a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT). Early diagnosis and treatment may improve patient outcomes. A prospective study to investigate the relationship between chimerism kinetics and the development of acute or chr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.02.011

    authors: Rupa-Matysek J,Lewandowski K,Nowak W,Sawiński K,Gil L,Komarnicki M

    更新日期:2011-06-01 00:00:00

  • Therapeutic monitoring of sirolimus: its contribution to optimal prescription.

    abstract::It is now common practice to measure immunosuppressive drugs in blood as a guide to therapy. The immunosuppressive drug sirolimus, recently approved for use following kidney transplantation, was developed in the context of this clinical approach. Throughout the early clinical studies, validated analytical techniques b...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/s0041-1345(03)00214-8

    authors: Holt DW,Denny K,Lee TD,Johnston A

    更新日期:2003-05-01 00:00:00

  • Early microchimerism in peripheral blood following kidney transplantation.

    abstract:BACKGROUND:The role of microchimerism found in the peripheral blood of renal transplant recipients remains a matter of debate. We assessed the frequency of microchimerism after kidney transplantation and examined its influence on clinical courses over a 12-month follow-up period. PATIENTS AND METHODS:Ten single-kidney...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.12.036

    authors: Kishikawa H,Kinoshita T,Yonemoto S,Kawamura M,Nakazawa S,Ueda N,Hirai T,Nishimura K,Hashimoto M,Ichikawa Y

    更新日期:2014-01-01 00:00:00

  • Long-term endoscopic follow-up in small bowel transplant recipients: single-center series.

    abstract:BACKGROUND:The reliability of endoscopic findings after adult intestinal transplantation on short-term follow-up has been shown. The aim of this study was to evaluate in a long-term follow-up the diagnostic value of endoscopies compared with the biopsy value. METHODS:We evaluated 52 endoscopies over a period of 2 year...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.07.025

    authors: Lauro A,Pinna AD,Pellegrini S,Bagni A,Zanfi C,Dazzi A,Pironi L,Di Simone MP

    更新日期:2014-09-01 00:00:00

  • Blood pressure control according to the prevalence of diabetes in renal transplant recipients.

    abstract::Hypertension is one of the most frequent complications of renal transplantation. About 70% to 90% of this population display either high blood pressure (BP) or require antihypertensive therapy. Diabetes mellitus is also a common finding among kidney transplant recipients. The aim of the study was to assess the BP cont...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.05.089

    authors: Zbroch E,Malyszko J,Glowinska I,Maciorkowska D,Kobus G,Mysliwiec M

    更新日期:2013-01-01 00:00:00

  • Evaluation of attitudes toward living organ donation: a multicenter study of compulsory secondary school education teachers.

    abstract:BACKGROUND:There is a considerable transplant organ deficit. To offset the organ shortage, living donation is being encouraged. Young persons form a sector of the population in whom early awareness is important to encourage favorable attitudes toward donation. Teachers play important roles in education and in generatin...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2010.05.076

    authors: Ríos A,Febrero B,Martínez-Alarcón L,López-Navas A,Sánchez J,Guzmán D,Ramírez P,Parrilla P

    更新日期:2010-10-01 00:00:00

  • Hepatic steatosis in liver transplant donors: rare phenomenon or common feature of donor population?

    abstract:AIM:The aim of this research was a histopathological assessment of cadaveric donor liver steatosis including: the degree (percent of involved hepatocytes) and type size of vacuoles showing fatty change by various histologic techniques. MATERIALS AND METHODS:The study included 70 donor livers. Hematoxylin-eosin and Sud...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.11.088

    authors: Hałoń A,Patrzałek D,Rabczyński J

    更新日期:2006-01-01 00:00:00

  • Ambulatory blood pressure monitoring in renal transplant patients: modifiable parameters after active antihypertensive treatment.

    abstract:BACKGROUND:Hypertension (HT) accounts for nearly 60% to 80% of renal transplant patients (RT). It is one of the most important risk factors for cardiovascular diseases and may cause chronic graft dysfunction. Therefore, it is important to accurately detect and treat HT. We aimed to evaluate the changes in ambulatory bl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.04.085

    authors: Oliveras A,Vázquez S,Hurtado S,Vila J,Puig JM,Lloveras J

    更新日期:2004-06-01 00:00:00

  • Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition.

    abstract::Portopulmonary hypertension (PoPH) is a common and feared complication of end-stage liver disease, and imposes increased risk of perioperative morbidity in the liver transplant patient. Herein, we present the first successful use of Imatinib in the perioperative management of a patient who was not responding to conven...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.02.100

    authors: Tapper EB,Knowles D,Heffron T,Lawrence EC,Csete M

    更新日期:2009-06-01 00:00:00

  • Calcineurin-free protocols with basiliximab induction allow patients included in "old to old" programs achieve standard kidney transplant function.

    abstract:INTRODUCTION:The EuroTransplant "old to old" program establishes that patients older than 60 years can receive offers of organs from donors older than 60 years. The compromised function of these organs makes it a priority to preserve their initial kidney function. HYPOTHESIS:Calcineurin-sparing protocols using anti-IL...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0041-1345(03)00379-8

    authors: Emparan C,Laukötter M,Wolters H,Dame C,Heidenreich S,Senninger N

    更新日期:2003-06-01 00:00:00

  • Mitral valve dysfunction and repair following orthotopic heart transplantation: a case report.

    abstract::Mitral valve dysfunction after orthotopic heart transplantation may cause symptoms refractory to medical therapy. In this report, we present a patient who underwent mitral annuloplasty for severe symptomatic mitral valve insufficiency 9 years after heart transplantation, and we critically appraise the literature avail...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.10.010

    authors: Wigfield CH,Lewis A,Parry G,Dark JH

    更新日期:2008-06-01 00:00:00