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Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial.

Abstract：

OBJECTIVE:To test in a prospective randomized study the hypothesis that use of thromboelastography (TEG) decreases blood transfusion during major surgery. MATERIAL AND METHODS:Twenty-eight patients undergoing orthotopic liver transplantation were recruited over 2 years. Patients were randomized into 2 groups: those monitored during surgery using point-of-care TEG analysis, and those monitored using standard laboratory measures of blood coagulation. Specific trigger points for transfusion were established in each group. RESULTS:In patients monitored via TEG, significantly less fresh-frozen plasma was used (mean [SD], 12.8 [7.0] units vs 21.5 [12.7] units). There was a trend toward less blood loss in the TEG-monitored patients; however, the difference was not significant. There were no differences in total fluid administration and 3-year survival. CONCLUSION:Thromboelastography-guided transfusion decreases transfusion of fresh- frozen plasma in patients undergoing orthotopic liver transplantation, but does not affect 3-year survival.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Wang SC,Shieh JF,Chang KY,Chu YC,Liu CS,Loong CC,Chan KH,Mandell S,Tsou MY

doi

10.1016/j.transproceed.2010.05.144

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

2590-3

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)00889-4

journal_volume

42

pub_type

杂志文章,随机对照试验

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