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Diagnostic performance of serum cystatin C and serum creatinine in the prediction of chronic kidney disease in renal transplant recipients.

Abstract：

BACKGROUND:Chronic kidney disease (CKD) has adverse impacts on mortality and morbidity of renal transplant recipients. Serum cystatin C (sCysC) is a novel marker in predicting the CKD. We therefore compare sCysC and serum creatinine (sCr) with the aim of improving the detection of CKD in renal transplant recipients. METHODS:We enrolled 106 renal transplant recipients and estimated glomerular filtration rates (GFR) using the Cockcroft-Gault (GFR(CG)) and the abbreviated Modification of Diet in Renal Disease (GFR(aMDRD)) formulae. We defined CKD as the presence of structural or functional kidney damage, irrespective of the diagnosis. Comparisons of sCysC and sCr in detecting CKD were analyzed. RESULTS:sCysC correlates with sCr significantly (r = 0.87; P < .001). The receiver operating characteristic curve demonstrates that sCysC has a better specificity and area under the curve, but less sensitivity than sCr in predicting CKD in renal transplant recipients if GFR is estimated by GFR(CG). Additionally, if GFR was estimated by GFR(aMDRD), the role of sCysC or sCr in prediction of CKD was comparable. CONCLUSION:sCysC may be better than sCr to detect CKD in renal transplant recipients using the GFR(CG).

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Tsai JP,Wu SW,Hung TW,Kao WT,Hong CL,Lian JD,Chang HR

doi

10.1016/j.transproceed.2010.09.150

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

4530-3

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)01584-8

journal_volume

42

pub_type

杂志文章

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