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A Comparison of the Effects of Sevoflurane and Desflurane on Corrected QT Interval Prolongation in Patients Undergoing Living Donor Liver Transplantation: A Prospective Observational Study.

Abstract：

BACKGROUND:QT interval prolongation has frequently been observed in patients with advanced liver disease. We investigated the influence of inhalation anesthetics on the corrected QT (QTc) interval prolongation during surgery in patients undergoing living-donor liver transplantation. METHODS:Our study included 43 patients who were assigned to 2 groups: sevoflurane (n = 22) or desflurane anesthesia (n = 21). QTc intervals were measured at perioperative determined time points and calculated using Fridericia's formula. RESULTS:Intraoperative QTc intervals increased during the peri-intubation period versus baseline (P = .003) and were prolonged during the peri-reperfusion period (P < .001). However, there was no significant difference in intraoperative QTc interval changes between patients given sevoflurane or desflurane (P = .59). CONCLUSIONS:In this prospective observational study, there was no significant difference in QTc intervals between sevoflurane and desflurane. QTc intervals increased during intubation and reperfusion relative to preoperative values in patients given either sevoflurane or desflurane.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Min JJ,Lee J,Lee HC,Ryu HG,Shin M,Kim HJ

doi

10.1016/j.transproceed.2015.12.034

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

96-101

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)01221-X

journal_volume

48

pub_type

杂志文章

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