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Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition.

Abstract：

:Portopulmonary hypertension (PoPH) is a common and feared complication of end-stage liver disease, and imposes increased risk of perioperative morbidity in the liver transplant patient. Herein, we present the first successful use of Imatinib in the perioperative management of a patient who was not responding to conventional treatments as well as our institution's experience with this devastating complication. Of patients evaluated for transplant, 4.1% were identified with PoPH, half of which were listed, and one quarter of which were transplanted. Patients with PoPH were twice as likely to be transplanted than all other candidates (48% vs 25%), though less likely to survive their first year (69% vs 86.4%).

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Tapper EB,Knowles D,Heffron T,Lawrence EC,Csete M

doi

10.1016/j.transproceed.2009.02.100

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

1969-71

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00451-5

journal_volume

41

pub_type

杂志文章

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