Risk Factors of Prolonged ICU Stay in Liver Transplant Recipients in a Single-Center Experience.


BACKGROUND:Prolonged initial intensive care unit (ICU) stay after liver transplantation (LT) is associated with prolonged total hospitalization, increased hospital mortality, and impaired patient and graft survival. Recent data suggested that model for end-stage liver disease (MELD) score at the time of LT and the length of surgery were the two independent risk factors for an ICU stay longer than 3 days after LT. We further identified factors influencing prolonged ICU stay in single-center liver graft recipients. PATIENTS AND METHODS:One hundred fifty consecutive LT recipients (M/F 94/56, median age 55 (range, 39-60), 36% with viral hepatitis, were prospectively enrolled into the study. Associations between clinical factors and prolonged ICU stay were evaluated using logistic regression models. Receiver operating characteristic curves were analyzed to determine the appropriate cutoffs for continuous variables. Threshold for significance was P ≤ .05. RESULTS:Highly prolonged (≥8 days) and moderately prolonged (≥6 days) postoperative ICU stay was noted in 19 (12.7%) and 59 (39.3%) patients, respectively. Serum bilirubin (P = .001) and creatinine concentrations (P = .011), international normalized ratio (P = .004), and sodium-MELD (P < .001) were all significantly associated with postoperative intensive care unit stay over or equal to 75th percentile (6 days). Sodium-MELD was significantly associated with postoperative care unit stay greater or equal to the 90th percentile (8 days; P = .018). CONCLUSIONS:Sodium-MELD might be a novel risk factor of prolonged ICU stay in this single-center experience.


Transplant Proc


Niewińsk G,Raszeja-Wyszomirska J,Główczyńska R,Figiel W,Zając K,Kornasiewicz O,Zieniewicz K,Grąt M




Has Abstract


2018-09-01 00:00:00














  • Expression of CD158b on peripheral blood lymphocytic cell after kidney transplantation.

    abstract:OBJECTIVE:To investigate the expression of CD158b on peripheral blood lymphocytes after kidney transplantation. METHODS:Sixty two kidney transplant patients were divided into two groups (normal group and rejection group) according to pathologic results and clinical situation. Blood samples were assessed for percentage...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kang N,Guan D,Xing N,Xia C

    更新日期:2005-03-01 00:00:00

  • Tacrolimus and Mycophenolic Acid Blood Concentration and Cellular Rejection After Heart Transplantation in First Endomyocardial Biopsy.

    abstract:BACKGROUND:Tacrolimus and mycophenolic acid (MPA) are the most important immunosuppressive drugs in modern heart transplantation. The pharmacokinetics of tacrolimus are best described by a 2-compartment model. MPA has very variable pharmacokinetics. The aim of this research was to compare kinetics of the immunosuppress...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nadziakiewicz P,Grochla M,Krauchuk A,Szyguła-Jurkiewicz B,Lorek J,Barańska A,Zembala MO,Przybyłowski P

    更新日期:2020-09-01 00:00:00

  • The Utility of Assessing Liver Allograft Fibrosis and Steatosis Post-Liver Transplantation Using Transient Elastography With Controlled Attenuation Parameter.

    abstract:AIM:Allograft steatosis is an emerging concern after liver transplantation (LT). The use of transient elastography (TE) with controlled attenuation parameter (CAP) may facilitate early detection of and intervention for allograft steatosis. This study aimed to evaluate the prevalence and risk factors of allograft steato...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chayanupatkul M,Dasani DB,Sogaard K,Schiano TD

    更新日期:2021-01-01 00:00:00

  • Body image in kidney transplantation.

    abstract:INTRODUCTION:Psychologic disturbances are becoming more common in kidney transplantation, owing to effects of immunosuppressive therapy. In this study, we explored the incidence and specifity of psychopathology among kidney transplant patients. Twenty kidney transplant recipients underwent the Machover Draw-A-person te...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: De Pasquale C,Pistorio ML,Sorbello M,Parrinello L,Corona D,Gagliano M,Giuffrida G,Giaquinta A,Sinagra N,Zerbo D,Veroux P,Veroux M

    更新日期:2010-05-01 00:00:00

  • Outcome of Living Donor Transplant Kidneys With Multiple Arteries.

    abstract:BACKGROUND:Living donor transplantation (LDT) using kidneys with multiple arteries (MA) has previously been reported to be associated with increased complications and poorer outcomes in recipients. The objective of this study was to investigate outcomes of LDT with MA at the National University Hospital of Singapore, a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lim YM,Han X,Raman L,Ng TK,Goh TH,Vathsala A,Tiong HY

    更新日期:2016-04-01 00:00:00

  • Police Officers' Knowledge and Attitudes Toward Brain Death and Organ Donation in Korea.

    abstract:BACKGROUND:Administrative processing by the police may affect the process involved in organ donation in the event of an accidental brain injury. The purpose of this study was to evaluate the knowledge and attitude of police toward brain-dead donors and organ donation. METHODS:This was a descriptive research study usin...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kim HS,Yoo YS,Cho OH,Lee CE,Choi YH,Kim HJ,Park JY,Park HS,Kwon YJ

    更新日期:2018-05-01 00:00:00

  • Fluorescence spectroscopy in renal ischemia and reperfusion: noninvasive evaluation of organ viability.

    abstract:BACKGROUND:Damage provoked by ischemia in renal transplants is difficult to quantify. To determine whether a donated organ is fit for transplantation. We sought to correlate the findings of fluorescence spectroscopy (FS) with histologic evidence of ischemic injury and organ viability. METHODS:Kidneys of 33 rats were s...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cassini MF,da Costa MM,Bagnato VS,Tirapelli LF,Silva GE,Molina CA,Martins AC,Tucci S Jr

    更新日期:2013-06-01 00:00:00

  • Atrophic Maxilla Reconstruction With Fresh Frozen Allograft Bone, Titanium Mesh, and Platelet-Rich Fibrin: Case Report.

    abstract::The purpose of this article was to report the clinical and radiographic findings about a case of a man affected by severely atrophic maxilla to demonstrate the clinical proceedings associated with alveolar reconstruction destined for dental implant rehabilitation. The 3-dimensional augmentation of the alveolar ridge w...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Baldan RCF,Coracin FL,Lins L,Mello WR,Santos PS

    更新日期:2017-05-01 00:00:00

  • Successful Treatment of Recurrent Focal Segmental Glomerulosclerosis After Transplantation in Children: A Single-Center Experience.

    abstract:OBJECTIVE:We aim to report our experience managing cases of recurrent focal segmental glomerulosclerosis (FSGS) in a group of pediatric renal transplant recipients. METHODS:This study was a retrospective chart review of pediatric patients who had their first kidney transplant at King Faisal Specialist Hospital & Resea...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alhasan KA,Alherbish A,Osman A,Kari JA,Almojalli H

    更新日期:2019-03-01 00:00:00

  • Ischemic preconditioning improves rat kidney allograft function after ischemia/reperfusion injury: the role of tumor necrosis factor-alpha.

    abstract:OBJECTIVE:The aim of this study was to investigate the early protection of ischemic preconditioning (IPC) and its mechanisms in transplanted rat kidneys. MATERIALS AND METHODS:Thirty-six male Sprague-Dawley (SD) rat donors and recipients were randomly divided into the following groups: sham-operated group (A; n = 6); ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jia RP,Xie JJ,Luo FY,Zhu JG

    更新日期:2008-12-01 00:00:00

  • Assessment of causes of early death after twenty years of liver transplantation.

    abstract:BACKGROUND:Postoperative poor graft function is a serious complication that can lead to graft loss requiring retransplantation or even death. The postoperative complications of primary nonfunction (PNF), early graft dysfunction (EGD), bleeding due to coagulopathy, and hepatic artery thrombosis (HAT) can lead to graft l...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Azevedo LD,Stucchi RS,Ataíde EC,Boin IF

    更新日期:2013-04-01 00:00:00

  • Molecular aspects of immune recognition of cytomegalovirus.

    abstract::The studies discussed in this presentation have shown that CD8 T lymphocytes have a primary role in conferring resistance to MCMV in the immunocompetent BALB/c mouse. In the presence of selective CD8 deficiency, however, other mechanisms, apparently mediated by the CD4 T-cell subset, contribute in a compensatory fashi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Koszinowski UH

    更新日期:1991-06-01 00:00:00

  • Liver transplant combined with heart transplant in severe heterozygous hypercholesterolemia: report of the first case and review of the literature.

    abstract::Familial hypercholesterolemia (FH) is a dominant inherited disease of low-density lipoprotein (LDL) metabolism caused by mutations of LDL receptors mainly located in the liver. This metabolic disorder is responsible for severe cardiovascular disease, from coronary lesions to chronic heart failure (CHF). Liver transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Alkofer BJ,Chiche L,Khayat A,Deshayes JP,Lepage A,Saloux E,Reznik Y

    更新日期:2005-06-01 00:00:00

  • Expanding the living donor pool, "Ist Act": analysis of the causes of exclusion of potential kidney donors.

    abstract:BACKGROUND:The evaluation of a potential living kidney donor (LKD) leads to exclusion of at least 50% of candidates. The aim of this study was to analyze the reasons for exclusion of potential LKDs referred to our center. METHODS:We retrospectively analyzed historic and clinical data of all potential LKDs who were eva...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Romagnoli J,Salerno MP,Calia R,Bianchi V,Pedroso JA,Spagnoletti G,Citterio F

    更新日期:2013-09-01 00:00:00

  • Synergistic effect of cold and warm ischemia time on postoperative graft function and outcome in human liver transplantation.

    abstract::Prolonged cold ischemia time (CIT) during graft preservation and warm ischemia time (WIT) during rewarming time have been reported to cause postoperative graft dysfunction after orthotopic liver transplantation (OLT). However, the effects of both CIT and WIT in combination on patient and graft survivals are not yet de...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Totsuka E,Fung JJ,Hakamada K,Ohashi M,Takahashi K,Nakai M,Morohashi S,Morohashi H,Kimura N,Nishimura A,Ishizawa Y,Ono H,Narumi S,Sasaki M

    更新日期:2004-09-01 00:00:00

  • Outcomes of simultaneous kidney-pancreas transplantation with positive cross-match.

    abstract::We studied 72 consecutive simultaneous pancreas kidney transplant (SPKT) recipients. There were 14 patients with positive pretransplant cross-matches (positive CDC- B cell and/or positive flow T or B cross-match). The control group included all 58 SPKT recipients with a negative crossmatch. The study group received in...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Heilman RL,Chakkera H,Mazur M,Petrides S,Moss A,Mekeel K,Mulligan D,Reddy KS

    更新日期:2009-01-01 00:00:00

  • Prevalence of obesity and metabolic changes after kidney transplantation: Hungarian pediatric cohort study.

    abstract:BACKGROUND:Cardiovascular mortality rate in patients with end-stage renal disease is 3 magnitudes higher than in the general population; it remains 10-fold higher after successful renal transplantation (Tx). Among others, obesity and hypertension can exert deleterious effects on vascular structure and function after Tx...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dégi AA,Kis E,Kerti A,Cseprekál O,Szabó AJ,Reusz GS

    更新日期:2014-07-01 00:00:00

  • PTFE mesh in renal allograft compartment syndrome.

    abstract::We report a case of anuria in a 42-year-old female kidney transplant patient that occurred secondary to extrinsic compression from a large kidney being placed extraperitoneally in a small iliac fossa. Prompt reexploration in the immediate postoperative period resulted in salvage of the graft with restoration of kidney...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Maione C,Gambino G,Di Bona A,Luna E,Turco D,Scio A,Damiano G,Virzì C,Gioviale MC,Buscemi G,Romano M,Lo Monte AI

    更新日期:2006-05-01 00:00:00

  • Kaposi sarcoma in solid organ transplant recipients: a single center report.

    abstract:BACKGROUND:Human herpes virus (HHV8) is associated with Castleman's disease, primary effusion lymphoma, and the Kaposi's sarcoma (KS). PATIENTS AND METHODS:Among 3815 solid organ transplants performed at our center between 1977 and 2003, five patients (0.1%) were identified with KS. RESULTS:There were one cardiac, on...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Boeckle E,Boesmueller C,Wiesmayr S,Mark W,Rieger M,Tabarelli D,Graziadei I,Hoefer D,Antretter H,Stelzmueller I,Krugmann J,Zangerle R,Huemer H,Poelzl G,Margreiter R,Bonatti H

    更新日期:2005-05-01 00:00:00

  • The role of invariant NKT cells in liver transplant tolerance in rats.

    abstract:OBJECTIVE:The aim of this study was to investigate the role of invariant natural killer T (iNKT) cells in liver transplant tolerance in rats. METHODS:Animals were randomly divided into 3 groups. The α-galactosylceramide (α-GalCer) group underwent injection through the caudal vein; the saline group received the same do...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Liu Y,Luan X,Li J,He Y,Li M

    更新日期:2012-05-01 00:00:00

  • Renal transplantation from cadaveric donor after myocardial revascularization: still a matter of concern?

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Segoloni GP,Quaglia M,Giacosa C,Ferro M,Martina G,Piccoli GB

    更新日期:2004-11-01 00:00:00

  • The clinical outcome of end-stage renal disease patients who return to peritoneal dialysis after renal allograft failure.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Yang KS,Kim JI,Moon IS,Choi BS,Park CW,Yang CW,Kim YS,Chung BH

    更新日期:2013-10-01 00:00:00

  • Impact of Donor-Recipient Age Difference on Graft Function and Survival After Deceased Donor Kidney Transplantation.

    abstract:BACKGROUND:Donor-recipient age difference (DRAD) is one of the reasons why patients on kidney waiting lists refuse to receive the offered organ. However, its impact on deceased donor kidney transplantation (DDKT) outcomes is still controversial. METHODS:One hundred fifty-three kidney transplant recipients (KTRs) who r...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kim GH,Lim JH,Park TH,Choi JY,Jung HY,Cho JH,Park SH,Kim YL,Kim HK,Huh S,Kim CD

    更新日期:2020-12-01 00:00:00

  • Expression of HLA molecules on peripheral blood lymphocytes: a useful monitoring parameter in cardiac transplantation.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Blanco-Garcia RM,López-Alvarez MR,Pascual-Figal DA,Polo-Garcia L,Guerra N,Campillo JA,Muro M,Garcia-Alonso AM,Marin-Moreno I,Valdes M,Alvarez-López MR,Minguela A

    更新日期:2007-09-01 00:00:00

  • Carbapenem-Resistant Klebsiella Pneumoniae Infections Early After Liver Transplantation: A Single-Center Experience.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mazza E,Prosperi M,Panzeri MF,Limuti R,Nichelatti M,De Gasperi A

    更新日期:2017-05-01 00:00:00

  • Effects of autologous bone marrow mononuclear cells implantation on cholangiocytes apoptosis in model of intrahepatic ischemic type biliary lesion in rabbits.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sheng QS,Chen WB,Lin JJ,Liu FL,Chen DZ

    更新日期:2012-06-01 00:00:00

  • Posttransplant lymphoproliferative disorder in pediatric liver transplantation.

    abstract::The success rate of pediatric liver transplantation has improved in recent years. Advances in immunosuppression have reduced the risk of rejection, but have enhanced the risk of posttransplant lymphoproliferative disorder (PTLD). Since 1994, we have performed 197 orthotopic liver transplantations in 157 recipients you...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Uribe M,Hunter B,Alba A,Calabrán L,Flores L,Soto P,Herzog C

    更新日期:2009-07-01 00:00:00

  • Use of Nonvascularized Abdominal Rectus Fascia After Liver, Small Bowel, and Multiorgan Transplantation: Long-Term Follow-up of a Single-Center Series.

    abstract:BACKGROUND:The abdominal wall may be severely compromised in the vast majority of intestinal and multiorgan transplant candidates, and sometimes as a consequence of complex liver transplantation. Multiple options have been described to overcome this problem, varying from component separation to the extreme need of perf...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Farinelli PA,Rubio JS,Padín JM,Rumbo C,Solar H,Ramisch D,Gondolesi GE

    更新日期:2017-10-01 00:00:00

  • Management of kidney transplantation in a factor VII-deficient patient: case report.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lapecorella M,Napolitano M,Lucchesi A,Pisani F,Clemente K,Rizza V,Famulari A,Aloisio L,Bernardi F,Pinotti M,Ferraresi P,Di Cocco P

    更新日期:2012-09-01 00:00:00

  • Perioperative kinetics of heat shock protein 60 in serum during orthotopic liver transplantation.

    abstract:INTRODUCTION:Heat shock proteins (HSP) play essential roles in the synthesis, transport, and folding of proteins. During ischemia/reperfusion (I/R) injury to orthotopic liver transplants (OLT), disassembly of oligomeric complexes and unfolding of proteins are likely to occur, producing a major burden on HSP to prevent ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Faybik P,Wachauer D,Hetz H,Bachleitner T,Steltzer H,Schett G,Krenn CG

    更新日期:2004-06-01 00:00:00