Bacterial Infections During Hospital Stay and Their Impact on Mortality After Lung Transplantation: A Single-Center Study.

Abstract:

INTRODUCTION:The aim of the study was to assess the impact of bacterial infection during hospital stay on long-term follow-up. MATERIALS AND METHODS:This was a retrospective single-center study of 97 recipients of lung transplantations performed between December 2004 and June 2016 at a single center. Information about age, sex, underlying lung disease, and date and type of procedure was gathered from patients' charts. Immunosuppressive treatment has been analyzed individually among the cohort. Microbiological evaluation included the presence of infection, bacterial species in recipients and donors, as well as type of biological material. RESULTS:During a mean hospitalization time of 57 days (range 4-398 days), 67 patients (69%) were diagnosed with bacterial infection. There were 120 episodes of infection caused by 32 species of bacteria. The most common were Pseudomonas aeruginosa (27%), Acinetobacter baumanii (21%), Klebsiella pneumoniae (10%) and Stenotrophomonas maltophilia (11%). Analysis revealed that 39 patients developed bronchiolitis obliterans syndrome (43%). Patients with A baumanii had a lower probability of survival than the rest of the population (P < .05). Patients treated with mammalian target of rapamycin inhibitors had a higher probability of survival. CONCLUSIONS:Infection with A baumanii affects lung transplant recipients' survival. Incorporating sirolimus could be beneficial for the lung transplant recipients' survival.

journal_name

Transplant Proc

authors

Wojarski J,Ochman M,Medrala W,Kulaczkowska Z,Karolak W,Maruszewski M,Urlik M,Wozniak-Grygiel E,Sioła M,Latos M,Biniszkiewicz P,Pyrc K,Zeglen S

doi

10.1016/j.transproceed.2017.11.080

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2064-2069

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30281-1

journal_volume

50

pub_type

杂志文章
  • Long-term outcomes of orthotopic heart transplantation for hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease characterized by asymmetric or symmetric ventricular hypertrophy in the absence of an obvious clinical cause. Orthotopic heart transplantation (OHT) has been performed in patients who have refractory symptoms despite medical therapy and surg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.12.052

    authors: Lee MS,Zimmer R,Kobashigawa J

    更新日期:2014-06-01 00:00:00

  • Neuropsychological changes in a large sample of liver transplant candidates.

    abstract::One-hundred forty-eight pre-liver transplant candidates completed a psychological interview and brief neuropsychological testing. Assessment measures included the Repeatable Battery of Neuropsychological Status, Shipley Institute of Living Scale, Trail Making Test Parts A and B (TMT-A and TMT-B), and the Folstein Mini...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.050

    authors: Meyer T,Eshelman A,Abouljoud M

    更新日期:2006-12-01 00:00:00

  • Nicardipine reverses vasoactivity associated with University of Wisconsin solution in the rat peripheral circulation.

    abstract:BACKGROUND:The rapid uniform delivery of University of Wisconsin solution (UW) to the microcirculation may be compromised by its vasoactivity. METHODS:In 2 different rodent models, we tested whether UW-mediated vasoconstriction could be reversed with nicardipine. RESULTS:In the perfused, splanchnic circulation, intra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.05.053

    authors: Raveh Y,Lubarsky DA,Pretto EA Jr,Proctor KG

    更新日期:2011-09-01 00:00:00

  • Effect of splenic artery embolization for splenic artery steal syndrome in liver transplant recipients: estimation at computed tomography based on changes in caliber of related arteries.

    abstract:PURPOSE:To estimate the effect of splenic artery embolization (SAE) on blood flow in orthotopic liver transplantation (OLT) recipients with splenic artery steal syndrome (SASS) based on changes in caliber of related arteries upon serial computed tomography (CT) scans. METHODS:Between 2004 and 2007, nine OLT recipients...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.02.022

    authors: Kim JH,Kim KW,Gwon DI,Ko GY,Sung KB,Lee J,Shin YM,Song GW,Hwang S,Lee SG

    更新日期:2011-06-01 00:00:00

  • Surveillance of Rejection After Intestinal Transplantation Using an Image Enhanced Endoscopy "VENCH" Scoring System.

    abstract:BACKGROUND:Graft rejection after intestinal transplantation remains challenging. We aimed to use endoscopy for rejection prediction. MATERIALS AND METHODS:Patients ≥7 years old who underwent intestinal transplantation between November 2016 and September 2019 were prospectively enrolled. Magnifying endoscopy under narr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.10.002

    authors: Chung CS,Tsai CC,Chen KC,Lin CK,Lee TH,Tsai HW,Chen Y

    更新日期:2021-01-01 00:00:00

  • Impact of immunosuppression on the development of Epstein-Barr virus (EBV) viremia after pediatric liver transplantation.

    abstract:OBJECTIVES:Pediatric liver transplant (OLT) patients are at risk of posttransplant lymphoproliferative disease (PTLD) from Epstein-Barr virus (EBV). This study examined the impact of induction and immunosuppression on EBV viremia. METHODS:A retrospective chart review was performed on 197 pediatric patients and inducti...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.04.035

    authors: Lu BR,Park KT,Hurwitz M,Cox KL,Berquist WE

    更新日期:2013-01-01 00:00:00

  • Analysis of urinary gene expression of epithelial-mesenchymal transition markers in kidney transplant recipients.

    abstract:INTRODUCTION:Renal graft dysfunction due to acute rejection, acute tubular necrosis, or anticalcineurin toxicity with development of interstitial fibrosis or tubular atrophy are the primary causes of graft failure. Determination of kidney function using the serum creatinine concentration demonstrates low sensitivity as...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.07.051

    authors: Gomez-Alamillo C,Benito-Hernandez A,Ramos-Barron MA,Agüeros C,Rodrigo E,Ruiz JC,Sanchez M,San Cosme L,Arias M

    更新日期:2010-10-01 00:00:00

  • Predicting fluid responsiveness in patients undergoing orthotopic liver transplantation: effects on intraoperative blood transfusion and postoperative complications.

    abstract:OBJECTIVE:To test the hypothesis that the restrictive volume therapy decreases blood transfusion requirement during liver orthotopic transplantation (OLT) without increasing acute renal complications and hospital length stay. MATERIAL AND METHODS:We conducted a retrospective cohort study (n = 89), randomized into 2 gr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.transproceed.2014.10.005

    authors: Lekerika N,Gutiérrez Rico RM,Arco Vázquez J,Prieto Molano L,Arana-Arri E,Martínez Indart L,Martínez Ruiz A,Ortiz de Urbina López J

    更新日期:2014-11-01 00:00:00

  • Anesthesia for ventricular assist device placement in pediatric patients: experience from a single center.

    abstract:BACKGROUND:The use of a ventricular assist device (VAD) as a bridge to heart transplantation in the pediatric population has evolved over the past decades This article presents our institution's clinical experience in the anesthetic management of pediatric patients with end-stage heart failure who underwent implantatio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.02.068

    authors: Kocabas S,Askar FZ,Yagdi T,Engin C,Ozbaran M

    更新日期:2013-04-01 00:00:00

  • Exercise performance comparison of bicaval and biatrial orthotopic heart transplant recipients.

    abstract:BACKGROUND:The standard biatrial technique for orthotopic heart transplantation uses a large atrial anastomosis to connect the donor and recipient atria. A modified technique involves bicaval and pulmonary venous anastomoses and is believed to preserve the anatomic configuration and physiological function of the atria....

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.08.085

    authors: Czer LS,Cohen MH,Gallagher SP,Czer LA,Soukiasian HJ,Rafiei M,Pixton JR,Awad M,Trento A

    更新日期:2011-12-01 00:00:00

  • Significance of HLA Antibody Detected by PRA-Bead Method in Kidney Transplant Outcomes.

    abstract:BACKGROUND:The impact of specific HLA antibodies on the allograft function in the Luminex era is not clearly known. This study aimed to investigate kidney transplantation outcomes in patients with different anti-HLA antibody status as detected by Luminex PRA. METHODS:This retrospective study included 106 deceased-dono...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.02.029

    authors: Wiwattanathum P,Ingsathit A,Thammanichanond D,Mongkolsuk T,Sumethkul V

    更新日期:2016-04-01 00:00:00

  • Evaluation of "flat-line" thromboelastography after reperfusion during liver transplantation.

    abstract:BACKGROUND:"Flat-line" (no clot formation) thromboelastography (TEG) is frequently observed after graft reperfusion during liver transplantation (LT). We aimed to evaluate the incidence and causes of flat-line TEG after graft reperfusion during LT. METHODS:With institutional review board approval, data of 208 consecut...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.11.032

    authors: Kim EH,Song SH,Kim GS,Ko JS,Gwak MS,Lee SK

    更新日期:2015-03-01 00:00:00

  • Effects of the antioxidants lycium barbarum and ascorbic acid on reperfusion liver injury in rats.

    abstract:OBJECTIVE:Ischemia/reperfusion (I/R) of the rat liver can induce liver injury through mechanisms involving oxidative and nitrosative stresses. In this study we examined the effects of antioxidants Lycium barbarum (LB) and ascorbic acid on I/R-induced liver injury in rats. METHODS:Liver ischemia was induced by clamping...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.08.051

    authors: Wang NT,Lin HI,Yeh DY,Chou TY,Chen CF,Leu FC,Wang D,Hu RT

    更新日期:2009-12-01 00:00:00

  • N-Acetylcysteine Use in Hepatic Ischemia/Reperfusion in Rats Minimizing Bowel Injury.

    abstract:BACKGROUND:The ischemia/reperfusion (I/R) phenomenon can cause the dysfunction of some transplanted organs and other distant organs. Liver surgery success, including transplantations, may depend on the adverse effects of intestinal mucosa injury arising from temporary porta triad occlusion. The study objective was to e...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.06.003

    authors: Lauz Medeiros SH,de Oliveira Menezes A,Zogbi L,Frasson de Souza Montero E

    更新日期:2016-09-01 00:00:00

  • Cancer in renal allograft recipients in Australia and New Zealand.

    abstract::Total incidence and outcome of cancer in all renal allograft recipients in one geographic area are known: 126 (7%) of 1884 patients developed cancer during an 11-year period. Proportions with cancer 1 and 5 years following successful transplantation were 11% and 24%, respectively. Numbers, proportion of malignancies, ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:

    authors: Sheil AG

    更新日期:1977-03-01 00:00:00

  • Changes in Renal Function After Heart Transplantation.

    abstract::Renal function after heart transplantation (HTx) typically follows a biphasic pattern and an initial decay within 1 to 2 years. Trajectory of renal function after HTx is less reported, especially in Asia. The aims of this cohort study were to describe the changes in HTx recipients' serum creatinine and estimated glome...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.02.196

    authors: Tsao CI,Ting M,Chou NK,Chi NH,Chen YS,Huang SC,Tsan CY,Wang CH,Yu HY,Shun CT,Wang SS

    更新日期:2018-11-01 00:00:00

  • Influence of Double-J Catheters on Urinary Infections After Kidney Transplantation.

    abstract:BACKGROUND:One of the most important problem in kidney transplantation is risk of the urinary anastomosis stricture. In uncertain cases the use of a double-J (or JJ) catheter is a standard solution. In case of urinary leak or fistula after the reanastomosis operation, transuretheral JJ implantation is used. A number of...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.03.003

    authors: Jonas M,Jóźwik A,Kawecki D,Durlik M,Pączek L,Młynarczyk G,Chmura A

    更新日期:2016-06-01 00:00:00

  • Graft-versus-host disease after liver transplantation: successful treatment of a case.

    abstract::Graft-versus-host disease (GVHD) is a rare, serious complication after liver transplantation. The incidence is about 1% abroad, but because of difficulties in diagnosis and treatment, the mortality rate is high (80%). Up to now, 78 patients have been reported to have this complication after liver transplantation world...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.03.164

    authors: Lu Y,Wu LQ,Zhang BY,Cao JY

    更新日期:2008-12-01 00:00:00

  • Lower Urinary Tract Symptoms Due to Xanthoma of the Prostate After Kidney Transplantation: A Case Report.

    abstract:BACKGROUND:Prostatic xanthoma is a lesion of unknown cause that is often an incidental finding in patients undergoing needle biopsy or transurethral resection. To the best of our knowledge, we report on a unique case of a pure xanthoma without benign prostatic hyperplasia of the prostate in a patient with lower urinary...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.02.180

    authors: Billis A,Freitas LLL,Costa LBE,Barreto IS,Botega AAR,Pereira TA,D'Ancona CA

    更新日期:2020-11-01 00:00:00

  • Utility of Basal Regional Oximetry as an Early Predictor of Graft Failure After Liver Transplant.

    abstract:INTRODUCTION:Adequate perfusion and oxygenation to liver graft after transplantation is essential for its viability. Hepatic oximetry (hepatic tissue oxygenation [LSrO2]) through near infrared spectroscopy (NIRS) can help by showing real time oxygen content of the graft. METHODS:In this prospective study, we enrolled ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.10.023

    authors: Pérez Civantos DV,Muñoz Cantero A,Robles Marcos M,Fuentes Morillas F,Cerezo Arias MO,Fariñas Seijas H

    更新日期:2019-03-01 00:00:00

  • Endoscopic treatment of bile duct complications after orthotopic liver transplantation.

    abstract:AIM:To assess the indications and results of endoscopic retrograde cholangio-pancreatography (ERCP) in patients who have undergone ortotopic liver transplantation (OLT). METHODS:We reviewed data from 42 consecutive patients who underwent ERCP for biliary complications after OLT over an 8-year period, in particular rec...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.05.053

    authors: Polese L,Cillo U,Brolese A,Boccagni P,Neri D,Bassi D,Erroi F,Zanus G,D'Amico DF,Norberto L

    更新日期:2007-07-01 00:00:00

  • New strategies of cyclosporine monitoring in heart transplantation: initial results.

    abstract::The aim of this study was to evaluate cyclosporine (CyA) absorption profiles in heart transplantation to establish the most adequate monitoring strategy and determine the optimal therapeutic range for AUC(0-4) or C2 levels. A total of 22 full pharmacokinetic studies were performed at steady-state in 22 adult heart tra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/s0041-1345(03)00657-2

    authors: Arizón del Prado JM,Aumente Rubio MD,Cárdenas Aranzana M,López Malo de Molina MD,Segura Saint-Gerons J,López Granados A,Rodríguez Esteban E,Ruiz Ortiz M,Romo Peñas E,Muñoz Carvajal I,González Rodríguez JR,Segura Saint-Gerons C,Va

    更新日期:2003-08-01 00:00:00

  • Outcome of intestinal transplants for patients with Crohn's disease.

    abstract:BACKGROUND:The pathophysiology of Crohn's disease (CD) is related to immune dysregulation making it unique among indications for intestinal transplants (ITx). We examined whether outcomes of ITx for CD are any worse than the overall ITx population. METHODS:United Network for Organ Sharing Standard Transplant Analysis ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.04.030

    authors: Desai CS,Khan K,Gruessner A,Gruessner R

    更新日期:2013-11-01 00:00:00

  • Development of humanized mice for the study of hepatitis C virus infection.

    abstract::The development of a small animal model for hepatitis C virus (HCV) infection is a critical issue for the development of novel anti-HCV drugs. To this aim, we have tried many different approaches for generating mice carrying humanized liver. Main efforts were focused on the transplantation of human hepatocytes into im...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.02.149

    authors: Turrini P,Sasso R,Germoni S,Marcucci I,Celluci A,Di Marco A,Marra E,Paonessa G,Eutropi A,Laufer R,Migliaccio G,Padron J

    更新日期:2006-05-01 00:00:00

  • Transplantation in Congenital Heart Disease: A Challenge.

    abstract:BACKGROUND:Heart failure is the leading cause of death in grown-up congenital heart disease patients (GUCH). Although heart transplantation (OHT) remains the gold standard in end-stage heart failure, the ratio of GUCH patients undergoing this procedure remains low. OBJECTIVE:Describe the cohort of GUCH patients underg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.12.027

    authors: Palomo-López N,Escalona-Rodríguez S,Martín-Villén L,Herruzo-Avilés Á,Hinojosa-Pérez R,Escoresca-Ortega A,Porras-López M,Corcia-Palomo Y,Adsuar-Gómez A

    更新日期:2020-03-01 00:00:00

  • Body image in kidney transplantation.

    abstract:INTRODUCTION:Psychologic disturbances are becoming more common in kidney transplantation, owing to effects of immunosuppressive therapy. In this study, we explored the incidence and specifity of psychopathology among kidney transplant patients. Twenty kidney transplant recipients underwent the Machover Draw-A-person te...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.03.071

    authors: De Pasquale C,Pistorio ML,Sorbello M,Parrinello L,Corona D,Gagliano M,Giuffrida G,Giaquinta A,Sinagra N,Zerbo D,Veroux P,Veroux M

    更新日期:2010-05-01 00:00:00

  • Pharmacokinetic differences between morning and evening administration of cyclosporine and tacrolimus therapy.

    abstract::We performed 24-hour monitoring of cyclosporine (NEO) and tacrolimus (TAC) blood concentrations, evaluating pharmacokinetic parameters and characterizing circadian variations. The monitoring was performed in 10 instances on nine patients administered NEO and 12 out of 11 patients administered TAC. All cases were admin...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.02.104

    authors: Iwahori T,Takeuchi H,Matsuno N,Johjima Y,Konno O,Nakamura Y,Hama K,Uchiyama M,Ashizawa T,Okuyama K,Nagao T,Abudoshukur M,Hirano T,Oka K

    更新日期:2005-05-01 00:00:00

  • Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.

    abstract:PURPOSE:The objective of this research was to survey the therapeutic action of simvastatin (Sim) on intestinal ischemia/reperfusion injury (II/RI) by modulating Omi/HtrA2 signaling pathways. METHODS:Sprague Dawley rats were pretreated with 40 mg/kg Sim and then subjected to 1 hour of ischemia and 3 hours of reperfusio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.04.076

    authors: Yan Y,Lv X,Ma J,Hong G,Li S,Shen J,Chen H,Cao K,Chen S,Cheng T,Dong C,Han J,Ma H,Wu M,Wang X,Xing C,Zhu Y,Shen L,Wang Y,Tong F,Wang Z

    更新日期:2019-10-01 00:00:00

  • 20-year experience with elderly donors in living renal transplantation.

    abstract:PURPOSE:This study evaluates the impact of living renal donors (LD) aged 60 years and older on graft performance and patient survival in an old-for-young constellation. PATIENTS AND METHODS:We analyzed 144 consecutive LDs between January 1983 and December 2002 (19 patients 60+/125 controls). RESULTS:Mean donor age in...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2003.10.034

    authors: Giessing M,Slowinski T,Deger S,Tuerk I,Schönberger S,Budde K,Loening SA

    更新日期:2003-12-01 00:00:00

  • Mild Hypothermia Pretreatment Attenuates Liver Ischemia Reperfusion Injury Through Inhibiting c-Jun NH2-terminal Kinase Phosphorylation in Rats.

    abstract:BACKGROUND:Mild hypothermia is known to be protected against ischemia reperfusion (IR) injury. But the exact mechanisms of protection have not yet been fully understood and its usage has been limited. Mild hypothermia pretreatment (MHP) is used to investigate the mechanisms of the protective effects against liver IR in...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2017.12.019

    authors: Wang W,Xiao Q,Hu XY,Liu ZZ,Zhang XJ,Xia ZP,Ye QF,Niu Y

    更新日期:2018-01-01 00:00:00