当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > High-mobility group box 1 protein activates hepatic stellate cells in vitro.

High-mobility group box 1 protein activates hepatic stellate cells in vitro.

Abstract：

OBJECTIVES:Our previous study noticed remarkably elevated titers of anti-high-mobility group box 1 (HMGB1) antibodies in sera during the tolerance induction phase of a rat tolerogenic orthotopic liver transplantation (OLT) as well as in sera of clinically drug-free patients. We hypothesized that the release of nonhistone nuclear protein HMGB1 during rejection may play a pathogenic role in deteriorating post-OLT graft functions, such as inducing liver fibrosis. This study sought to investigate whether HMGB1 can directly activate hepatic stellate cells (HSCs) and drive them toward fibrogenesis. METHODS:The cultured HSCs were treated with recombinant HMGB1. RT-PCR and Western blotting analysis were used to measure alpha-smooth muscle actin (alpha-SMA) expression. Conditioned media were collected for gelatin zymography to monitor the activities of collagen-degrading matrix metalloproteinases (MMPs). RESULTS:HMGB1 at concentrations > 1 ng/mL significantly stimulated HSC growth as revealed by proliferation and BrdU assays. alpha-SMA gene and protein expression were significantly up-regulated by HMGB1, whereas the MMP-2, but not MMP-9, activity was suppressed by HMGB1 treatment. CONCLUSION:Our data suggested that HMGB1 protein, once released during the rejection phase of OLT, activated HSCs and exhibited profibrogenic effects on liver grafts either by increasing the HSC population and extracellular matrix content in liver grafts, or by transforming HSCs into myofibroblasts. Neutralization with anti-HMGB1 antibody was suggested to be a therapeutic modality applicable to prevent fibrogenesis in post-OLT liver grafts.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kao YH,Jawan B,Goto S,Hung CT,Lin YC,Nakano T,Hsu LW,Lai CY,Tai MH,Chen CL

doi

10.1016/j.transproceed.2008.07.055

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

2704-5

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)00892-0

journal_volume

40

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Impact of patient characteristics and comorbidity profile on activation of patients on the kidney transplantation waiting list.

    abstract：BACKGROUND:The aim of this study was to examine which demographic and comorbidity factors affected the activation of patients with end-stage renal disease on the national kidney transplantation waiting list. METHODS:This was a prospective cohort study across 13 transplantation centers in the United Kingdom from Octobe...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2013.03.033

    authors： Akolekar D,Forsythe JL,Oniscu GC

    更新日期：2013-07-01 00:00:00

  • Effects of N-acetylcysteine in hepatic ischemia-reperfusion injury during hemorrhagic shock.

    abstract：:This article seeks to standardize an experimental model of liver ischemia-reperfusion in rats following hemorrhagic shock modulated by N-acetylcysteine (NAC). Twenty-seven adult Wistar rats were randomized into three groups: the HS-IR-Garm underwent hemorrhagic shock with selective hepatic ischemia followed by reperfu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.03.047

    authors： Portella AO,Montero EF,Poli de Figueiredo LF,Bueno AS,Thurow AA,Rodrigues FG

    更新日期：2004-05-01 00:00:00

  • Conversion to everolimus in liver transplant patients with renal dysfunction.

    abstract：:Calcineurin inhibitor (CNI) immunosuppressive therapy post-liver transplantation (OLT) is important to reduce graft rejection episodes. However, these drugs show important side effects, particularly renal dysfunction (RDF). Changing from CNI to a nonnephrotoxic drug, as mammalian target of rapamycin (mTOR) inhibitor m...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.06.009

    authors： Pérez T,Segovia R,Castro L,Roblero JP,Estela R

    更新日期：2011-07-01 00:00:00

  • Cancer in renal allograft recipients in Australia and New Zealand.

    abstract：:Total incidence and outcome of cancer in all renal allograft recipients in one geographic area are known: 126 (7%) of 1884 patients developed cancer during an 11-year period. Proportions with cancer 1 and 5 years following successful transplantation were 11% and 24%, respectively. Numbers, proportion of malignancies, ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Sheil AG

    更新日期：1977-03-01 00:00:00

  • Homocysteine-lowering therapy and carotid intima-media thickness in renal transplant recipients.

    abstract：:The aim of this study was to document, in hyperhomocysteinemic renal transplant recipients, the effect of vitamin supplementation on carotid intima-media thickness (cIMT). Fifty-six hyperhomocysteinemic stable renal transplant recipients were randomly assigned to either vitamin supplementation (group A) or placebo tre...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2005.06.101

    authors： Marcucci R,Zanazzi M,Bertoni E,Rosati A,Fedi S,Lenti M,Prisco D,Castellani S,Abbate R,Salvadori M

    更新日期：2005-07-01 00:00:00

  • Early graft dysfunction after liver transplantation.

    abstract：:Liver transplantation has become the treatment of choice for fulminant hepatic failure and end-stage liver diseases. Several factors have been described to be predictors of graft function. Since early graft dysfunction dramatically influences graft and patient outcomes after liver transplantation, prevention of this e...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2010.02.004

    authors： Briceño J,Ciria R

    更新日期：2010-03-01 00:00:00

  • Augmentation of tissue ATP level during digestion using preoxygenated perfluorocarbon results in high islet yield-new strategy for islet isolation.

    abstract：BACKGROUND:Recently, preservation using oxygenated perfluorocarbon (the two-layer method) has shown beneficial effects on islet yield and viability. In this paper, we apply this concept on isolation processes to examine the effectiveness of oxygenation. METHODS:Rat pancreata were digested using four different methods:...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.232

    authors： Tanioka Y,Tanaka T,Gotoh T,Kakinoki K,Li S,Yoshikawa T,Sakai T,Fujino Y,Suzuki Y,Kuroda Y

    更新日期：2005-01-01 00:00:00

  • The acoustic radiation force impulse elastography evaluation of liver fibrosis in posttransplantation dysfunction of living donor liver transplantation.

    abstract：BACKGROUND:The acoustic radiation force impulse elastography (ARFI) is a new technology of elastography integrated into B-mode ultrasonography. It has been a reliable method to evaluate liver fibrosis of chronic liver disease in recent years, but less applied in the posttransplantation liver. The aim of the study was t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.12.012

    authors： Liao CC,Chen TY,Tsang LC,Ou SY,Yu CY,Hsu HW,Cheng YF,Chiu KW,Eng HL,Chen CL,Huang TL

    更新日期：2014-04-01 00:00:00

  • Graft-vs-Host Disease-Induced Hyperthyroidism in a Recipient of Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report.

    abstract：BACKGROUND:Hyperthyroidism after hematopoietic stem cell transplantation (HSCT) is rare, and only a few cases have been reported. What is more important, the fundamental mechanisms of hyperthyroidism after HSCT remained unclear. CASE:A 28-year-old man received an HLA haploidentical related-donor HSCT for acute myeloid...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.021

    authors： Huang F,Liao N,Guan Y,Jin H,Ye J,Fan Z,Xuan L,Liu Q,Shi P

    更新日期：2020-11-01 00:00:00

  • Management of uncommon hernias in cirrhotic patients.

    abstract：BACKGROUND:Abdominal hernias are a common disease among cirrhotic patients, because of malnutrition and persistently high intra-abdominal pressure due to ascites. When tense ascites is present, life-threatening complications are likely to occur. In such cases, the morbidity and mortality rates are high. OBJECTIVE:We d...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.090

    authors： Andraus W,Sepulveda A,Pinheiro RS,Teixeira AR,D'Albuquerque LA

    更新日期：2010-06-01 00:00:00

  • Early hepatic artery thrombosis after liver transplantation: diagnosis and treatment.

    abstract：BACKGROUND:Hepatic artery thrombosis (HAT) occurs in 3% to 9% of all liver transplantations with acute graft failure as a possible sequel. METHODS:Eleven episodes of HAT were identified among 256 orthotropic liver transplantations (whole, LDCT, split) performed on 253 patients between April 1993 and July 2006. HAT was...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.02.017

    authors： Nikeghbalian S,Kazemi K,Davari HR,Salahi H,Bahador A,Jalaeian H,Khosravi MB,Ghaffari S,Lahsaee M,Alizadeh M,Rasekhi AR,Nejatollahi SM,Malek-Hosseini SA

    更新日期：2007-05-01 00:00:00

  • Combination protocols for prevention of CMV disease in the high risk transplant patient.

    abstract：:Overall, the results seen in this study are encouraging. In this high-risk group of patients where the expected disease rate would normally be at least 55% to 60% without prophylaxis, a combination protocol of GCV, ACV, and CMVIG limited the rate of disease to 19%. When disease occurred, it was generally mild and easi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：

    authors： Martin M

    更新日期：1996-12-01 00:00:00

  • Porcine Transgenic, Acellular Material as an Alternative for Human Skin.

    abstract：:Although new therapeutic approaches for burn treatment have made progress, there is still need for efficient coverage of donor fields. Promising dressing for skin graft donor site should be biocompatible, attach easily to the wound bed, remain in place until donor site has renewed, and decrease morbidity at the site. ...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.transproceed.2020.01.125

    authors： Kitala D,Klama-Baryła A,Łabuś W,Kraut M,Glik J,Kawecki M,Joszko K,Gzik-Zroska B

    更新日期：2020-09-01 00:00:00

  • Facial Nerve Palsy Complicated by Masked Tuberculous Mastoiditis in a Recently Transplanted Patient.

    abstract：:Mastoiditis is a complication of the medium otitis characterized by suppuration and destruction of the mastoid cells and the pyramid petrosa; its tuberculous etiology has decreased in the last 40 years. Paralysis resulting from mastoiditis is more common in children. The incidence of mastoiditis has risen, although th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.007

    authors： Hernandez Fustes OJ,Rodriguez CA,Ferreira GME,Borges FZ

    更新日期：2020-11-01 00:00:00

  • Italian continuing medical education program: an evidence-based course for surgeons and health personnel of a regional transplantation center.

    abstract：:In the organ transplantation area the application of the evidence-based medicine (EBM) methods may be limited by several, heterogeneous conditions, eg, mandatory laws and protocols, logistic concerns, as well as donor/recipient matching. In this report we have described the results of a first EBM-oriented course for s...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.01.135

    authors： Santori G,Renzini AM,Lasagna F,Casaccia M,Fontana I,Valente U

    更新日期：2011-05-01 00:00:00

  • Genetic association of tumor necrosis factor-β, interleukin-10, and interleukin-1 gene cluster polymorphism with susceptibility to pneumonia in kidney transplant recipients.

    abstract：INTRODUCTION:Pneumonia remains a significant cause of morbidity and mortality after kidney transplantation. The present study was therefore conducted to investigate whether or not the polymorphisms of tumor necrosis factor (TNF)β, interleukin (IL)-10, IL-1β, and IL-1 receptor antagonist (IL-1ra) gene predicted the susc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.02.122

    authors： Wan QQ,Li JL,Ye QF,Zhou JD

    更新日期：2013-07-01 00:00:00

  • Laparoscopic organ retrieval for living donor liver transplantation does not prevent graft injury.

    abstract：:The cause of transplant failure may be difficult to define. However, organ retrieval before preservation and transplantation is an important factor. Organ manipulation during harvesting, which is inevitable with most techniques, leads to injury upon reperfusion including microcirculatory disturbances. Recently, laparo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.020

    authors： Schemmer P,Barro-Bejarano M,Mehrabi A,Gebhard MM,Kraus T,Büchler MW,Gutt CN

    更新日期：2005-04-01 00:00:00

  • Learning and new discovery with cyclosporine in the Cambridge-King's Programme: a personal view.

    abstract：:Immunosuppressive regimens in the early precyclosporine days of liver transplantation for the Cambridge-King's Programme from 1968 until the early 1980s were inadequate in the control of rejection. The consequent use of high-dose steroids led to many infections, which seriously affected outcome. Nevertheless, occasion...

    journal_title：Transplantation proceedings

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.transproceed.2004.01.007

    authors： Williams R

    更新日期：2004-03-01 00:00:00

  • Clinical Accuracy of Average Creatinine and Cystatin-C-Based Estimated GFR in Japanese Living Renal Transplantation Donors.

    abstract：OBJECTIVE:To evaluate the clinical accuracy of several estimated glomerular filtration rates (eGFR) using cystatin-C to measure renal function in Japanese renal donors. METHODS:In total, 61 healthy, potential renal donors were assessed. The average age was 42.7 years (range: 27-67). We evaluated the GFR based on the 2...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.013

    authors： Morizawa Y,Satoh H,Iwasa S,Sato A,Aoki Y,Hamada R

    更新日期：2020-12-01 00:00:00

  • Correlation of the Volume Control Parameters With Health Related Quality of Life in Renal Transplant Patients.

    abstract：INTRODUCTION:Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during the pre- and post-transplantation periods. MATERIAL AND METHODS:Se...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.04.012

    authors： Colak H,Sert I,Ekmekcı C,Tugmen C,Kurtulmus Y,Kursat S,Töz H

    更新日期：2015-06-01 00:00:00

  • Ambulatory blood pressure monitoring in renal transplant patients: modifiable parameters after active antihypertensive treatment.

    abstract：BACKGROUND:Hypertension (HT) accounts for nearly 60% to 80% of renal transplant patients (RT). It is one of the most important risk factors for cardiovascular diseases and may cause chronic graft dysfunction. Therefore, it is important to accurately detect and treat HT. We aimed to evaluate the changes in ambulatory bl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.04.085

    authors： Oliveras A,Vázquez S,Hurtado S,Vila J,Puig JM,Lloveras J

    更新日期：2004-06-01 00:00:00

  • Role of magnetic resonance imaging in the detection of anastomotic biliary strictures after liver transplantation.

    abstract：INTRODUCTION:Biliary complications after orthotopic liver transplantation (OLT) are the principal cause of morbidity and graft dysfunction, ranging in incidence from 5.8% to 30% of cases. Biliary strictures are the most frequent type of late complication. The aim of this study was to evaluate the role of magnetic reson...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.03.016

    authors： Pecchi A,De Santis M,Gibertini MC,Tarantino G,Gerunda GE,Torricelli P,Di Benedetto F

    更新日期：2011-05-01 00:00:00

  • Risk factors for the development of new-onset diabetes mellitus in a living related renal transplant program.

    abstract：:New-onset diabetes mellitus is associated with considerable morbidity after transplantation. We evaluated 78 living related renal transplant recipients due to all causes except diabetic nephropathy a waiting a living related renal transplantation. We evaluated demographic characteristics, pretransplant glycemic profil...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.10.008

    authors： Bora GS,Guleria S,Reddy VS,Tandon N,Gupta N,Gupta S,Bhowmik D

    更新日期：2010-12-01 00:00:00

  • Attrition from heart transplant waiting list for patients on ventricular assist devices is not affected by desensitization strategies.

    abstract：BACKGROUND:Ventricular assist device (VAD) patients, who are commonly sensitized, can be successfully transplanted using strategies aimed at diminishing antibody burden. However, the impact of these therapies on outcomes for VAD patients on the waiting list is ill-defined. The following study was conducted to ascertain...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.016

    authors： Gonzalez-Stawinski GV,Cook DJ,Smedira NG,Navia JL,Taylor DO,Yamani MH,Hoercher K,Starling RC,Banbury MK

    更新日期：2007-06-01 00:00:00

  • Impact of Donor-Recipient Age Difference on Graft Function and Survival After Deceased Donor Kidney Transplantation.

    abstract：BACKGROUND:Donor-recipient age difference (DRAD) is one of the reasons why patients on kidney waiting lists refuse to receive the offered organ. However, its impact on deceased donor kidney transplantation (DDKT) outcomes is still controversial. METHODS:One hundred fifty-three kidney transplant recipients (KTRs) who r...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.02.163

    authors： Kim GH,Lim JH,Park TH,Choi JY,Jung HY,Cho JH,Park SH,Kim YL,Kim HK,Huh S,Kim CD

    更新日期：2020-12-01 00:00:00

  • Simultaneous pancreas-kidney transplantation: a single-center experience and prospective analysis.

    abstract：:In patients with end-stage chronic kidney disease (CKD) and type 1 diabetes mellitus (DM 1), simultaneous pancreas-kidney (SPK) transplantation is currently considered the gold standard therapy. The aim of this study was to analyze and report the long-term clinical outcomes of the 23 SPK transplantations performed at ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.05.059

    authors： Rossi M,Lai Q,Spoletini G,Poli L,Nudo F,Ferretti S,Della Pietra F,Pugliese F,Ferretti G,Novelli G,Pretagostini R,Berloco PB

    更新日期：2008-07-01 00:00:00

  • Liver transplantation for hilar cholangiocarcinoma: a German survey.

    abstract：BACKGROUND:The present study reports a German survey addressing outcomes in nonselected historical series of liver transplantation (OLT) for hilar cholangiocarcinoma (HL). PATIENTS AND METHODS:We sent to all 25 German transplant centers performing OLT a survey that addressed (1) the number of OLTs for HL and the perio...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2008.08.039

    authors： Kaiser GM,Sotiropoulos GC,Jauch KW,Löhe F,Hirner A,Kalff JC,Königsrainer A,Steurer W,Senninger N,Brockmann JG,Schlitt HJ,Zülke C,Büchler MW,Schemmer P,Settmacher U,Hauss J,Lippert H,Hopt UT,Otto G,Heiss MM,Bechste

    更新日期：2008-11-01 00:00:00

  • The effect of epigenetic factors on differentiation of pancreatic progenitor cells into insulin-producing cells.

    abstract：:Differentiation of pancreatic progenitors into insulin-producing β cells is regulated by various transcription factors. To be expressed the genes coding these transcription factors need to be in accessible DNA. Whether a particular gene is present in a form of active euchromatin structure with accessible DNA or in an ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.10.025

    authors： Leontovyč I,Koblas T,Pektorova L,Zacharovova K,Berkova Z,Saudek F

    更新日期：2011-11-01 00:00:00

  • Transplantation of a Kidney With Duplicated Ureter Harvested From a Donor With Vascular Anomaly in the Form of Double Inferior Vena Cava: A Case Report.

    abstract：:During the organ procurement procedure, a surgeon encounters anatomic anomalies not very often but also not uncommonly. These changes may put the success of the transplant into question. Despite the thorough diagnosis of the potential donor, these anomalies are often diagnosed during organ donation. In our paper we pr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.02.089

    authors： Pilichowska E,Ostrowski P,Kotowski MJ,Tejchman K,Ostrowska-Clark K,Ostrowski M,Sieńko J

    更新日期：2020-10-01 00:00:00

  • Attitudes of the Third-Year Nursing Students Toward Organ Donation: Cross-Sectional Study.

    abstract：BACKGROUND:Health professionals can affect attitudes toward organ donation in society; therefore, priority should be given to exploration of attitudes of nursing students as important prospective members of the health profession. The goal of this study was to assess nursing students' attitudes and volunteerism toward o...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.04.024

    authors： Akpınar Söylemez B,Ordin YS

    更新日期：2017-10-01 00:00:00