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Homocysteine-lowering therapy and carotid intima-media thickness in renal transplant recipients.

Abstract：

:The aim of this study was to document, in hyperhomocysteinemic renal transplant recipients, the effect of vitamin supplementation on carotid intima-media thickness (cIMT). Fifty-six hyperhomocysteinemic stable renal transplant recipients were randomly assigned to either vitamin supplementation (group A) or placebo treatment (group B). All patients underwent high-resolution B mode ultrasound to measure IMT of common carotid arteries before and after 6 months of vitamin supplementation. In group A, cIMT significantly decreased after treatment, whereas no significant changes were observed in group B. In conclusion, our results demonstrate a beneficial effect of the treatment of hyperhomocysteinemia by vitamin supplementation on an early sign of atherosclerosis in a group of renal transplant recipients.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Marcucci R,Zanazzi M,Bertoni E,Rosati A,Fedi S,Lenti M,Prisco D,Castellani S,Abbate R,Salvadori M

doi

10.1016/j.transproceed.2005.06.101

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

2491-2

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00737-2

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验

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