Metaanalysis of statins and survival in de novo cardiac transplantation.


BACKGROUND:The use of HMG CoA reductase inhibitors (statins) after cardiac transplantation has been suggested to decrease the incidence of severe rejection and improve survival. Individual investigations that have led to this suggestion are randomized (but not placebo-controlled) studies, including small patient numbers that have (and thus underpowered) and enrolling heterogeneous subjects (including retransplant recipients). The purpose of this pooled analysis was to quantify the benefit of statins on survival in de novo cardiac transplant recipients. METHODS:Medline (1966 to 2003) was queried using the keywords statin, HMG CoA reductase inhibitors, cardiac transplantation, transplant, cholesterol, atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. In addition, we searched the cited literature and previously published systematic reviews. Of 36 articles retrieved, 3 randomized controlled studies met our population inclusion criteria; namely age >18 years, de novo heart transplant recipients, statin therapy within 3 months, and > or = 1-year follow-up. Pooled data were metaanalyzed by Mantel-Haenszel tests using a random effects model that included tests for heterogeneity. RESULTS:The three pooled studies included 246 patients (statin, n = 129; no statin, n = 117) and 27 events (11%). The pooled analysis demonstrated a significant reduction in mortality with statin use (RR 0.31; 95% CI 0.13 to 0.7; P = .006) without significant heterogeneity (P = .7) among the studies. Two of the three studies reported allograft rejection with hemodynamic compromise. The pooled analysis demonstrated a significant benefit on this endpoint (RR 0.22, 95% CI 0.08 to 0.63; P = .004). CONCLUSION:This meta-analysis demonstrates that statin therapy decreases rejection episodes with hemodynamic consequences and improves 1-year heart transplant survival.


Transplant Proc


Mehra MR,Raval NY




Has Abstract


2004-06-01 00:00:00














  • Preliminary results of a prospective randomized study of cyclosporine versus tacrolimus in the development of cardiac allograft vasculopathy at 1 year after heart transplantation.

    abstract:INTRODUCTION AND AIMS:Cardiac allograft vasculopathy (CAV) is the leading cause of death after the first year post-heart transplantation (HT). Numerous factors have been implicated in the development of CAV. The aim of this prospective randomized study was to assess the impact of cyclosporine (CsA) and tacrolimus (Tac)...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Sánchez-Lázaro IJ,Almenar-Bonet L,Martínez-Dolz L,Buendía-Fuentes F,Navarro-Manchón J,Raso-Raso R,Agüero J,Salvador-Sanz A

    更新日期:2010-10-01 00:00:00

  • Injection of donor-derived OX62+ splenic dendritic cells with anti-CD4 monoclonal antibody generates CD4+CD25+FOXP3+ regulatory T cells that prolong allograft skin survival indefinitely and abrogate production of donor-specific antibodies in a rat model.

    abstract:OBJECTIVE:To examine in a rat model the ability of donor dendritic cells and anti-CD4 monoclonal antibody (mAb) to generate donor-specific CD4+CD25+ regulatory T cells (Tregs) and to evaluate the capacity of these Tregs to prolong skin allograft survival and abrogate the production of donor-specific antibodies after sk...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alawieh M,Rifle G,Bouchot O,Malapert G,Mousson C,Martin L

    更新日期:2009-10-01 00:00:00

  • Hepatitis C and the incidence of diabetes mellitus after renal transplant: influence of new immunosuppression protocols.

    abstract:BACKGROUND:Hepatitis C has been associated with an increased incidence of diabetes mellitus (DM) following renal transplantation (RT). METHODS:Patients who underwent RT between 1985 and 2001 were excluded if they showed DM prior to RT, graft survival of less than 90 days, and unknown anti-HCV status (n=15). Two groups...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gentil MA,López M,González-Roncero F,Rodríguez-Algarra G,Pereira P,López R,Martínez M,Toro J,Mateos J

    更新日期:2003-08-01 00:00:00

  • Laparoscopic hepatectomy for a modified right graft in adult-to-adult living donor liver transplantation.

    abstract:BACKGROUND:We performed a modified right hepatectomy completely by laparoscopic techniques preserving the middle hepatic vein (MHV) branches in adult-to-adult living donor liver transplantation (LDLT). PATIENTS AND METHODS:Two young women (24 and 25 years old) volunteered to be live donors for their parents who had he...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Suh KS,Yi NJ,Kim J,Shin WY,Lee HW,Han HS,Lee KU

    更新日期:2008-12-01 00:00:00

  • Urological complications after simultaneous pancreas-kidney transplantation.

    abstract:OBJECTIVE:We evaluated the incidence of urological complications after simultaneous renal and pancreatic transplantation. PATIENTS AND METHODS:We retrospectively reviewed urological complications following 107 simultaneous kidney-pancreas transplantations performed at our institution between March 1995 and June 2008. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Medina Polo J,Morales JM,Blanco M,Aguirre JF,Andrés A,Díaz R,Jiménez C,Leiva O,Meneu JC,Moreno E,Pamplona M,Passas J,Rodríguez A,de la Rosa F

    更新日期:2009-07-01 00:00:00

  • Living donor renal transplantation using grafts with multiple arteries procured by laparoscopic nephrectomy.

    abstract:OBJECTIVE:Kidney grafts with multiple renal arteries (MRAs) are not uncommon, but they do make transplantation more difficult. Laparoscopic graft nephrectomy has become the standard; however, the safety and reliability must be maintained for both a donor and a recipient even in case of MRAs. This study evaluated the sh...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kitada H,Doi A,Nishiki T,Miura Y,Kurihara K,Kawanami S,Tanaka M

    更新日期:2010-09-01 00:00:00

  • Prolongation of islet allograft survival by coexpression of CTLA4Ig and CD40LIg in mice.

    abstract:BACKGROUND:B7/CD28 and CD40/CD40L have been well established as important costimulatory pathways. Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) delivers negative signals to antigen-presenting cells to down-regulate proinflammatory responses and competitively inhibits the binding of B7 and CD28. Signals from the C...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Li ZL,Xue WJ,Tian PX,Ding XM,Tian XH,Feng XS,Hou J

    更新日期:2007-12-01 00:00:00

  • De novo colorectal cancer: five-year survival is markedly lower in transplant recipients compared with the general population.

    abstract:INTRODUCTION:The biological behavior of most solid tumors in transplant recipients has not been adequately compared to the general population. The purpose of the present study was to compare outcomes in de novo colorectal cancer (CRC) following solid organ transplantation to those observed in the general population (SE...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Buell JF,Papaconstantinou HT,Skalow B,Hanaway MJ,Alloway RR,Woodle ES

    更新日期:2005-03-01 00:00:00

  • Bone marrow progenitors from animals with chronic renal failure lack capacity of in vitro proliferation.

    abstract:BACKGROUND:An interesting way to regenerate a kidney is an autologous bone marrow transplantation. The aim of this study was to examine whether chronic kidney disease influenced bone marrow progenitors. METHODS:Wistar male rats included group I (n = 4, chronic kidney disease 1/2, CKD 1/2) that underwent right nephrect...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Drewa T,Joachimiak R,Kaznica A,Flisinski M,Brymora A,Manitius J

    更新日期:2008-06-01 00:00:00

  • Deep vein thrombosis during rabbit antithymocyte globulin administration.

    abstract:INTRODUCTION:Rabbit antithymocyte globulin (RATG) is recommended for central administration, and no evidence justifies the common practice of adding heparin to the bag, but the evaluation of thrombocytopenia may be complicated by coadministration. We recently phased out the use of heparin in RATG in our kidney and kidn...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mathis AS,Rao V

    更新日期:2004-12-01 00:00:00

  • Two doses of daclizumab with delayed introduction of low-dose tacrolimus in elderly recipients of cadaveric renal transplants from donors >55 years of age.

    abstract:BACKGROUND:Renal transplants from elderly donors have a high incidence of delayed graft function, which can be increased by the initial use of calcineurin inhibitors. Our purpose was to assess the safety and efficacy of an immunosuppressive regimen using anti-IL-2R antibodies and MMF that allows delayed introduction of...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章


    authors: Osuna A,Gentil MA,Capdevila L,Cantarell C,Mazuecos A,Pereira P,Rodríguez-Algarra G,González-Molina M,Spanish Kidney Transplant of Elderly Donor Study Group.

    更新日期:2005-04-01 00:00:00

  • Fibromyalgia and its clinical relevance in renal transplant recipients.

    abstract:OBJECTIVE:Recent evidence suggests that fibromyalgia syndrome (FS) is associated with inflammation and endothelial dysfunction. Our aim was to determine the prevalence of FS in renal transplant recipients and to identify possible links between FS and clinical and laboratory parameters. METHODS:Ninety-nine kidney trans...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Erkmen Uyar M,Sezer S,Bal Z,Guliyev O,Tutal E,Genctoy G,Kulah E,Ozdemir Acar N,Haberal M

    更新日期:2015-05-01 00:00:00

  • Mode of delivery in women after liver transplantation.

    abstract:AIM:A high rate of cesarean sections has been reported among high-risk pregnancies in liver transplant recipients. The aim of this study was to analyze the course of deliveries and the indications for cesarean sections in women after liver transplantation. MATERIALS AND METHODS:From 2001 to 2006, we noted 21 deliverie...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jabiry-Zieniewicz Z,Bobrowska K,Pietrzak B,Kaminski P,Wielgos M,Durlik M,Zieniewicz K

    更新日期:2007-11-01 00:00:00

  • Health-related quality of life after pediatric liver transplant: single-center experience in Chile.

    abstract:INTRODUCTION:Orthotopic liver transplantation is the treatment of choice for most terminal liver diseases in children. Currently, the improved survival of these patients is well documented, but their quality of life post-transplant is not described. In Chile, Hospital Luis Calvo Mackenna (HLCM) has performed pediatric ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alba A,Uribe M,Hunter B,Monzón P,Ferrada C,Heine C,Auad H

    更新日期:2013-01-01 00:00:00

  • Urological complications in kidney transplantation: ureterocystostomy versus uretero-ureterostomy.

    abstract::In our initial experience of kidney transplantation, we performed an extravesical uretero-cystostomy (U-C), but in 1997 we shifted to a uretero-ureterostomy (U-U) with the aim of reducing early and late urological complications. A data base was constructed to compare the incidence, donor and recipient risk factors, tr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Faenza A,Nardo B,Fuga G,Liviano-D'Arcangelo G,Grammatico F,Montalti R,Bertelli R,Beltempo P,Puviani L

    更新日期:2005-07-01 00:00:00

  • Reliability and Accuracy of Clinical Assessment and Digital Image Analysis for Steatosis Evaluation in Discarded Human Livers.

    abstract:BACKGROUND:Accurate assessment of steatosis in procured livers is crucial to reduce the poor outcome associated with high-grade steatosis and to optimize the utilization of donor grafts. Clinical examination and digital image analysis (DIA) have been used for steatosis evaluation, but the validity of these methods is d...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Abudhaise H,Luong TV,Watkins J,Fuller BJ,Davidson BR

    更新日期:2019-01-01 00:00:00

  • Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allografts.

    abstract::It is well known that interferon-gamma (IFN-gamma) not only plays a critical role in antigen-dependent but also in antigen-independent tissue injury; however, it is not clear how tolerance induction affects the actions of IFN-gamma in the transplant setting. To address this question, we compared the effects of IFN-gam...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hoerbelt R,Benjamin LC,Shoji T,Johnston DR,Muniappan A,Guenther DA,Allan JS,Houser SL,Madsen JC

    更新日期:2006-12-01 00:00:00

  • Effect of cyclosporine on expression of MIC in human hepatocytes.

    abstract:OBJECTIVES:The human major histocompatibility complex class I chain-related antigen A, B (MICA, B) are believed to be "cell stress sensors," which encode stress-inducible surface proteins that bind to NKG2D, an activating receptor of NK, alpha beta and gamma delta T cells. While cyclosporine (CsA) has improved patient ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: He Y,Li S,Feng L,Cheng F,Ye Z,Li Y

    更新日期:2006-09-01 00:00:00

  • The Innsbruck hand transplant program: update at 8 years after the first transplant.

    abstract::We herein provide an update on two bilateral hand and one bilateral forearm transplants with emphasis on immunosuppression (IS), function, morphology, and graft vascular changes at 8 years and 2 years after bilateral hand and 5 years after bilateral forearm transplantation. Between March 2000 and May 2006, three patie...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Brandacher G,Ninkovic M,Piza-Katzer H,Gabl M,Hussl H,Rieger M,Schocke M,Egger K,Loescher W,Zelger B,Ninkovic M,Bonatti H,Boesmueller C,Mark W,Margreiter R,Schneeberger S

    更新日期:2009-03-01 00:00:00

  • Dynamics of changes in heart conduction system in dialyzed young adults after kidney transplantation--pilot study.

    abstract:BACKGROUND:Cardiovascular complications are the main clinical problem in patients with end-stage renal failure (ESRF). After successful kidney transplantation, this situation improves, although cardiovascular complications remain a risk factor for increased mortality in these patients; therefore, their early identifica...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Laszki-Szcząchor K,Zwolińska D,Sobieszczańska M,Makulska I,Polak-Jonkisz D

    更新日期:2014-10-01 00:00:00

  • Brain death caused by electric shock and organ donation in children.

    abstract:INTRODUCTION:There are still few publications about brain death caused by electric shock and the use of organs for donation in this situation. We sought to present our experience, with brain dead pediatric donors caused by electric shock. MATERIAL AND METHODS:Notification registers of potential donors were analyzed fr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Todeschini DP,Maito ED,Maldotti A,Moreira AL,Capaverde FB,Figueiredo FM,Oliveira DM,Costa MG,Hoelfmann N,Londero GG,Leães PE,Garcia VD

    更新日期:2007-03-01 00:00:00

  • Hepatitis C virus recurrence after liver transplantation: influence of immunosuppressive regimens on viral load and liver histology.

    abstract::Cyclosporine has recently been reported to produce in vitro suppression of hepatitis C virus replication driven by blockade of cyclophilins, an effect not shown for tacrolimus. However, the clinical consequence of this in vitro finding have not been well studied in vivo. We compared viral load and fibrosis in transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Oton E,Barcena R,Castillo M,Barreales M,Blesa C,Moreno-Planas JM,Barrios C,Garrido A,Cuervas V

    更新日期:2006-10-01 00:00:00

  • Analysis of late operations in transplant patients.

    abstract:OBJECTIVE:The charts of 174 consecutive patients were analyzed for incidence, etiology, and outcome of late operations (1 month or more posttransplant) following liver (OLT), kidney (KT), or pancreas-kidney (SPK) transplantation. MATERIALS AND METHODS:Clinical and demographic data were analyzed by chi-square analysis ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Merhav H,Eisner S,Nakache R

    更新日期:2004-12-01 00:00:00

  • The cost of steroid-free protocols in primary cadaver kidney transplantation.

    abstract::Steroid-free immunosuppression regimens have been enjoying recent success in clinical transplantation. The use of antibodies required for such protocols can be an economic burden. We proposed to study their cost in our center. This retrospective study involved 147 consecutive patients subjected to 4 protocols of immun...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nghiem DD,Carpenter BJ,Schlosser JD,Sureshkumar K,Vivas CA,Frowen SE,Marcus RJ

    更新日期:2005-05-01 00:00:00

  • Contraceptive Choices and Counseling in Norwegian Female Renal Transplant Recipients.

    abstract:BACKGROUND:There are major gaps in the understanding of sexual and reproductive health in female renal transplant recipients. METHODS:In this Norwegian multicenter retrospective observational study, 118 female renal transplant recipients aged 22 to 49 years responded to a questionnaire on fertility, contraceptive use,...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究


    authors: Eide IA,Rashidi F,Lønning K,Oldereid NB,Reisæter AV,Åsberg A,Midtvedt K

    更新日期:2019-03-01 00:00:00

  • Postoperative Myocardial Injury Does Not Predict Early and 1-Year Mortality After Living Donor Liver Transplantation.

    abstract:BACKGROUND:Preoperative cardiac troponin-I (cTnI) elevation has been shown to be a predictor of mortality after liver transplantation. Myocardial injury after non-cardiac surgery (MINS) has been defined as elevation of serum cardiac troponin levels in the perioperative period that does not fulfill the criteria for myoc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Canbolat IP,Adali G,Akdeniz CS,Bozkurt B,Ferah O,Bulutcu F,Yuzer Y,Tokat Y

    更新日期:2019-09-01 00:00:00

  • Cardiac and Neurologic Complications in the Late Period After Liver Transplantation: A Retrospective Analysis of 4 Years.

    abstract:BACKGROUND AND OBJECTIVE:The aim of our study was to assess the cardiac and neurologic complications after liver transplantation in the late period. METHOD AND PATIENTS:Medical records of 198 patients who had liver transplantation in the organ transplantation center of our university hospital between between February ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dogan U,Yaprak M,Dogan EA,Onac M,Aydinli B

    更新日期:2019-05-01 00:00:00

  • Experience with cyclosporine in the Canary Islands.

    abstract::Cyclosporine (CsA) is currently the basis of most immunosuppressive protocols after solid organ transplantation. The introduction of Neoral, a new microemulsion formulation of CsA, and more recently a range of adjunctive immunosuppressants have further enhanced short-term efficacy and tolerability of CsA-based immunos...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Hernández D

    更新日期:2004-03-01 00:00:00

  • Epidemiologic and Economic Aspects Related to Hemodialysis and Kidney Transplantation in Santa Catarina in the Period of 2012-2013.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide public health problem and is expressed by increasing amounts of patients on renal replacement therapy (RRT), with significant economic and social impacts. The aim of this work was to analyze socioeconomic and mortality aspects of CKD patients in Santa Catarina (SC)...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Silva AT,Soares LB,Magajewski FR

    更新日期:2016-09-01 00:00:00

  • CTLA4-Fas ligand gene transfer mediated by adenovirus induce long-time survival of murine cardiac allografts.

    abstract:BACKGROUND:Fas ligand gene transfer to induce peripheral allograft tolerance in animal models has shown controversial results. The immunosuppression effects mediated by engineered FasL depend on whether alloreactive T cells are selectively deleted. In the present study, we tested the feasibility of a strategy to induce...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Feng YG,Jin YZ,Zhang QY,Hao J,Wang GM,Xie SS

    更新日期:2005-06-01 00:00:00