Simultaneous pancreas-kidney transplantation: a single-center experience and prospective analysis.

Abstract:

:In patients with end-stage chronic kidney disease (CKD) and type 1 diabetes mellitus (DM 1), simultaneous pancreas-kidney (SPK) transplantation is currently considered the gold standard therapy. The aim of this study was to analyze and report the long-term clinical outcomes of the 23 SPK transplantations performed at our institution over an 84-month period (January 1, 2000 to December 31, 2006). A prospective analysis of these patients included donor, recipient, and transplantation characteristics. The only requirements for transplantation were blood group compatibility and a negative cross-match. Bladder drainage via pancreaticoduodenocystostomy was performed in all of the patients. Due to a pulmonary embolus 1 patient (4.3%) died at 2 months. The actuarial patient survival rates at 3 months and 1, 3, and 5 years were 95.6%. Causes for the renal graft loss were chronic allograft nephropathy in 3 cases (13%) and death of the patient in 1 case (4.3%). The actuarial censored renal allograft survival rates at 3 months and at 1 year were 100%, and at 3 and 5 years were 91.3%. Causes for the renal graft loss were chronic rejection in 1 case (4.3%) and patient death in 1 case (4.3%). The actuarial censored pancreatic allograft survival rates at 3 months and at 1 and 3 years were 100%, and at 5 years was 95.6%. The results of this work add further evidence that SPK is the gold standard therapy for selected patients with end-stage CKD due to DM 1.

journal_name

Transplant Proc

authors

Rossi M,Lai Q,Spoletini G,Poli L,Nudo F,Ferretti S,Della Pietra F,Pugliese F,Ferretti G,Novelli G,Pretagostini R,Berloco PB

doi

10.1016/j.transproceed.2008.05.059

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

2024-6

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)00642-8

journal_volume

40

pub_type

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