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Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies.

Abstract：

:We previously reported that mouse embryonic stem (ES) cells are capable of differentiating into hepatocytes in cultured embryoid bodies (EBs) and that hepatocytes generate in the recipient liver injected with cultured day-9 EB cells via spleen without the formation of a teratoma. Because ES cells frequently form teratomas in recipient mice, we investigated incidence of teratoma formation when day-9 EBs derived from ES cells were transplanted directly into the subcapsule of mouse liver. In contrast to injection of day-9 EB cells through the portal vein via the spleen, direct subcapsular injection of cultured day-9 EB cells into liver, and even of cultured day-15 EBs, resulted in an high incidence of teratoma in the liver. In teratomas of livers injected directly with day-15 EBs, hepatocytes were detected singly and in clusters. These results imply that undifferentiated cells capable of developing into teratomas exist in cultured EBs, and even in cultured day-15 EBs containing differentiated hepatocytes.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Teramoto K,Hara Y,Kumashiro Y,Chinzei R,Tanaka Y,Shimizu-Saito K,Asahina K,Teraoka H,Arii S

doi

10.1016/j.transproceed.2004.12.120

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

285-6

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)01557-X

journal_volume

37

pub_type

杂志文章

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