In vitro evaluation of new possible cell engraftment enhancers for cell transplantation.

Abstract:

:Orthotopic liver transplantation (OLT) is the best treatment to restore liver function in liver failure. The low availability of organs has focused interest on the use of cell transplantation to restore liver function. However, this technique is limited because cells can not bind to liver parenchyma and die soon after perfusion. Pretransplant treatment with engraftment enhancers (EE) to increase vascular permeability may increase cell attachment. Using an endothelial cell culture to measure the loss of intercellular endothelial adhesion as a screening test, we evaluated the capacity of 15 monoclonal antibodies against adhesion molecules expressed on endothelial cells to act as EE showing that 3 antibodies (anti-CD54, efalizumab, and abciximab) act as EE by producing disruptions in the cell layer.

journal_name

Transplant Proc

authors

Alfaro FJ,Checa A,Ramírez E,Cevey M,Meneu JC,Abradelo M,Moreno E,Paz-Artal E,Mellado M,Serrano A

doi

10.1016/j.transproceed.2010.02.010

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

671-2

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)00152-1

journal_volume

42

pub_type

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