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Efficacy of subcutaneous epoetin-zeta on anemia in renal transplant recipients: a single-center experience.

Abstract：

BACKGROUND:Persistent or "de novo" anemia (plasma hemoglobin<11 g/dL) may complicate the graft outcome in a significant number of renal transplant recipients. We describe a single-center experience with epoetin-zeta (EPO-Z), the biosimilar form for epoetin-alfa. METHODS:Twenty patients were included in the study, 10 in treatment with different erythropoiesis-stimulating agents (ESA) and shifted to EPO-Z (shift group) and 10 who started EPO-Z treatment for anemia (naive group). All the patients had stable renal function and normal values of main inflammation markers and were prospectively followed up for 12 months. Iron supplements were administered during the study, as needed. RESULTS:In the shift group, mean plasma hemoglobin levels>11 g/dL were maintained for the entire 1-year follow-up period, with average EPO-Z doses 3.4% higher than the corresponding doses of previous ESA; in the naive group, the target value was reached between the first and third months and remained stable throughout the study. Mean corpuscular volume did not vary in either group. No change was observed in glomerular filtration rate, nor in proteinuria or in main laboratory data. No drug-related side effect was reported. CONCLUSIONS:EPO-Z may be considered a valid alternative to different ESAs in renal transplant recipients, with an interesting pharmaco-economic profile, considering its lower cost.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sabbatini M,Vitale S,Garofalo G,Torino M,Gallo R,Carrano R,Federico S

doi

10.1016/j.transproceed.2014.07.027

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

2238-40

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00530-2

journal_volume

46

pub_type

杂志文章

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