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Clinical trial of Tripterygium Wilfordii Hook F. in human kidney transplantation in China.

Abstract：

OBJECTIVE:In this study, the effects of Triptergium Wilfordii Hook F.(T II) were assessed on human kidney allograft rejection and long-term survival. METHODS:This study compared treatment with T II(T II group, n=121) to that without T II(control group, n=102) among adult first cadaveric renal transplant recipients. The T II cohort of 121 recipients were divided into a regular dosage group (n=82) and a double dosage group (n=39). No antibody induction was administered to any patient. RESULTS:Biopsy-proven early acute allograft rejection occurred in 4.1% of patients in the T II group versus 24.5% of patients in the control group. No rejection or repeated rejections occurred in the double dosage group at 3 months after transplantation. Acute rejection episodes were milder in the T II than the control group. The incidence of CD25+ cells>10/ mm3 in the allografts at 3 months after transplantation was lower in the T II group than the control group, 15% and 50%, respectively. All patients tolerated T II well over the 5 years of this study. The 5-year graft survival censored for death with function was 96.7% in the T II group and 80.4% in the control group. CONCLUSION:T II was effective to prevent renal allograft rejection and increase long-term renal allograft survival among adult cadaveric renal transplant recipients.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Ji SM,Wang QW,Chen JS,Sha GZ,Liu ZH,Li LS

doi

10.1016/j.transproceed.2006.03.017

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1274-9

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)00277-6

journal_volume

38

pub_type

杂志文章

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