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Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up.

Abstract：

INTRODUCTION:Diagnosis of thyroid disease is fundamental in the evaluation of patients awaiting kidney transplantation. We analyzed the incidence of thyroid disease in patients with end-stage renal disease (ESRD) and evaluated its evolution before and after kidney transplantation. PATIENTS AND METHODS:Between January 2000 and May 2008, we evaluated 323 candidates for kidney transplantation. In all patients, serum concentrations of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were determined and a ultrasonography of the neck was performed. Patients with thyroid cancer were considered eligible for kidney transplantation after at least 2 years since treatment. RESULTS:One-hundred-four patients with ESRD (44%) had functional or morphologic changes in the thyroid gland. Forty-one patients (17.4%) underwent fine-needle aspiration cytology; 3 demonstrated showed papillary carcinoma; 3, follicular adenomas; 8, uncertain cytologic lesions; and 27, a nodular goiter. Seventeen patients underwent surgery. Six of 11 patients with thyroid cancer underwent transplantation: two patients underwent laterocervical lymph node dissection because of local recurrence within 2 years after successful transplantation; the other 4 patients are alive with a functioning graft. Of the 184 transplant recipients, 10 underwent surgery to treat thyroid disease: 8 with multinodular goiter, 1 with micropapillary carcinoma, and 1 with follicular adenoma. All 10 patients are alive with a well-functioning graft and no signs of disease recurrence. CONCLUSIONS:Thyroid diseases are common in patients with ESRD. Early diagnosis and treatment significantly decreased morbidity and mortality in patients awaiting transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Veroux M,Giuffrida G,Gagliano M,Giaquinta A,Tallarita T,Sorbello M,Corona D,Zerbo D,Vizcarra D,Scriffignano V,Cannizzaro MA,Veroux P

doi

10.1016/j.transproceed.2009.03.014

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1142-4

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00401-1

journal_volume

41

pub_type

杂志文章

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