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Early urine output predicts graft survival after kidney transplantation.

Abstract：

BACKGROUND:In kidney transplantations, the identification of early postoperative parameters with high predictive power for the development of late allograft dysfunction has important implications for clinical practice. This study sought to determine these parameters in a single-center cohort. METHODS:We studied 82 deceased donor renal transplantation. We assessed the following measures: dialysis-dependent delayed graft function (ddDGF), extended DGF, serum creatinine level at day 7, creatinine reduction ratio at day 7, urine output at day 1 and at day 7 posttransplantation (UO7). RESULTS:Only UO7 showed a significant result upon multivariate analysis (P < .0001). It was less influenced by dialysis with respect to measures based upon serum creatinine. By Receiver Operating characteristic (ROC) analysis, it showed an elevated area under the curve (0.811), with a cut-off value of 500 mL/24 h, showing high sensitivity (98.5%). CONCLUSIONS:UO7 may be of clinical utility to assess the risk for subsequent renal dysfunction.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Lai Q,Pretagostini R,Poli L,Levi Sandri GB,Melandro F,Grieco M,Spoletini G,Rossi M,Berloco PB

doi

10.1016/j.transproceed.2010.03.088

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

1090-2

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)00376-3

journal_volume

42

pub_type

杂志文章

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