当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital.

Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital.

Abstract：

BACKGROUND:We describe an observational, retrospective study that included patients who underwent a liver transplantation (LT) for hepatocellular carcinoma (HCC) in our center between 2004 and 2012. METHODS:Clinical variables were recorded for donors and recipients as diagnosis and treatment, immunosuppressive therapy, toxicity, graft dysfunction, recurrence, and exitus. Fifty-eight patients were analyzed. The mean age was 57 ± 8 years. The viral etiology of HCC was 50% (n = 29), alcoholic 26% (n = 15), and others, 24% (n = 14). Regarding initial immunosuppressive strategy (IS), 51 patients (87.9%) were treated with standard regimen with corticosteroids (CS) and tacrolimus (TA), compared with 7 patients with impaired renal function (12.1%) who underwent a delayed therapy with calcineurin inhibitors (CNI) + mycophenolate mophetil (MMF) + CS. Concomitant use of anti-CD25 monoclonal antibodies was less than 10%. Regarding maintenance, 43 patients (74.1%) were treated with MMF + CNI versus 15 treated only with TA (25.9%). RESULTS:Recurrence of HCC was approximately 12%: 7 patients (2 hepatic only, 5 also extra-hepatic). Exitus was established in 19 patients (32.75%); only 3 patients (5.17%) were attributable to HCC. Bivariate studies were conducted according to the initial IS (standard regimen versus delayed therapy) and maintenance therapy (MMF + TA versus TA alone), with no differences in any of them in recurrence, treatment toxicity, graft rejection, and dysfunction. CONCLUSIONS:In our experience with the IS, we found no differences in the development of recurrent disease, treatment toxicity, development of graft dysfunction, or rejection. We believe that individualized immunosuppressive therapy in these patients is safe and effective.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

San Miguel C,Fundora Y,Triguero J,Muffak K,Villegas T,Becerra A,Garrote D,Ferrón JA

doi

10.1016/j.transproceed.2015.08.020

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

2371-3

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00770-8

journal_volume

47

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Chronic rejection after combined liver and small bowel transplantation in a child with chronic intestinal pseudo-obstruction: a case report.

    abstract：:An 11-year-old boy with irreversible intestinal failure secondary to chronic intestinal pseudo-obstruction (CIPO) and intestinal failure-associated liver disease (IFALD) underwent a combined en bloc reduced liver and small bowel transplantation. He was discharged home after 9 weeks on full oral intake without requirin...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.01.066

    authors： Giovanelli M,Gupte GL,Sharif K,Mayer DA,Mirza DF

    更新日期：2008-06-01 00:00:00

  • Renal ischemia-reperfusion injury: new implications of dendritic cell-endothelial cell interactions.

    abstract：:In renal ischemia/reperfusion (I/R) injury endothelial cells are a main target. The disturbance of endothelial cell physiology leads to endothelial swelling and narrowing of the blood vessel lumen. We attribute this effect to impairment of endothelial cell nitric oxide synthase (NOS). NO is significantly reduced in th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2006.01.059

    authors： Schlichting CL,Schareck WD,Weis M

    更新日期：2006-04-01 00:00:00

  • A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

    abstract：BACKGROUND:Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate (CHIP) with equivalent functional and inflammator...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.05.007

    authors： Buchko MT,Himmat S,Aboelnazar NS,Stewart CJ,Hatami S,Dromparis P,Adam B,Freed DH,Nagendran J

    更新日期：2020-12-01 00:00:00

  • Hand-assisted Laparoscopic Left Donor Nephrectomy Without a Hand-assisted Device: Is it Possible?

    abstract：BACKGROUND:Live donor nephrectomy is an important donor source. Donor nephrectomy can be performed by laparoscopy or hand-assisted laparoscopy. Different types of hand port devices can be used for assistance. In the literature there are few studies about hand-assisted laparoscopy without a hand port. In this study, we ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.07.016

    authors： Karabay O,Tasci H,Hasbahceci M,Kadioglu H

    更新日期：2019-12-01 00:00:00

  • Real-time monitoring of nitric oxide (NO) and pO2 levels under ischemic conditions associated with small bowel ischemia/reperfusion injury using selective electrodes for NO and oxygen molecules.

    abstract：:The present study demonstrated the feasibility of monitoring nitric oxide (NO) and pO2 levels under ischemic conditions associated with small bowel ischemia/reperfusion (I/R) injury through the use of selective electrodes for NO and oxygen molecules. NO levels gradually increased during ischemia. When reperfusion was ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.08.090

    authors： Watanabe T,Owada S,Kobayashi H,Ishiuchi A,Nakano H,Asakuta T,Shimamura T,Asano T,Koizumi S,Jinnouchi Y,Katayama M,Kamibayasi M,Murakami E,Otsubo T

    更新日期：2007-12-01 00:00:00

  • The treatment of deep vein thrombosis immediately after kidney transplantation: a case report.

    abstract：:Ipsilateral acute iliofemoral deep vein thrombosis (DVT) immediately after kidney transplantation is rare but highly morbid, resulting in allograft failure, rupture, or even death. Treatment modalities for iliofemoral DVT occurring just after transplantation are limited due to bleeding risk and impaired renal function...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.05.041

    authors： Hwang JK,Chun HJ,Moon IS,Kim JI

    更新日期：2011-07-01 00:00:00

  • Human herpes virus-8 serology and DNA analysis in recipients of renal allografts showing Kaposi's sarcoma and their respective donors.

    abstract：:Kaposi's sarcoma (KS) developed among 11 of 416 renal allograft recipients transplanted between 1985 and 2000. Only 3 among 364 Caucasian recipients developed KS, while it affected 8 of 52 Black patients, all of whom had been born in African countries (P <.001). All patients had their immunosuppression reduced; two al...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.05.023

    authors： Weigert AL,Pires A,Adragão T,Cardoso E,Cardoso C,Sancho R,Trindade H,Pimentel MS,Casqueiro A,Machado D

    更新日期：2004-05-01 00:00:00

  • Association Between Dyspnea and Severity of Liver Disease in Patients in the Pre-transplantation Period-A Pilot Study.

    abstract：BACKGROUND:Liver transplantation is indicated at the end stage of chronic liver failure, and severity of disease will determine the precocity of this happening. At this stage, the presence of chronic dyspnea is one of several manifestations of progression of the disease, which leads the patient to inactivity. A rehabil...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.06.027

    authors： Monte da Silva AG,deA Roza Aguiar B,Chiavegato LD

    更新日期：2016-09-01 00:00:00

  • Donor evaluation for lung transplantation in Korea.

    abstract：:Lung transplantation for end-stage lung disease results in prolonged survival and improved pulmonary function. However, the shortage of donor lungs has been a major limiting factor in Korea. We sought to investigate the number and utilization of donor lungs by the five institutions performing LTx in Korea, retrospecti...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2011.12.060

    authors： Paik HC,Haam SJ,Lee DY,Yi GJ,Song SW,Kim YT,Kang CH,Kim KM,Park SI,Jheon SH

    更新日期：2012-05-01 00:00:00

  • H1N1 vaccination in pediatric renal transplant patients.

    abstract：BACKGROUND:Solid organ transplant recipients undergoing immunosuppressive therapy are considered to be at high risk of serious infectious complications. In 2009, a new influenza pandemic caused serious infections and deaths, especially among children and immunocompromised patients. Herein we have reported the safety an...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.03.072

    authors： Kelen K,Ferenczi D,Jankovics I,Varga M,Molnar MZ,Sallay P,Reusz G,Langer RM,Pasti K,Gerlei Z,Szabo AJ

    更新日期：2011-05-01 00:00:00

  • Immunomodulation, Acute Renal Failure, and Complications of Basiliximab Use After Liver Transplantation: Analysis of 114 Patients and Literature Review.

    abstract：:Basiliximab is considered to be effective in preventing cellular rejection (CR) in solid organ transplantation and is commonly used for renal transplants. The aim of this study was describe the population of patients undergoing orthotopic liver transplantation (LT) receiving basiliximab in the period 2012-2016 in the ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2017.01.047

    authors： de Ataide EC,Perales SR,Bortoto JB,Peres MAO,Filho FC,Stucchi RSB,Udo E,Boin IFSF

    更新日期：2017-05-01 00:00:00

  • The reduction of hypoxia-induced and reoxygenation-induced apoptosis in rat islets by epigallocatechin gallate.

    abstract：:The survival of transplanted tissue is affected by the detrimental consequences of hypoxia followed by reoxygenation. The majority of transplanted cells undergo apoptosis due to hypoxia and reoxygenation (H/R) injury, but protection from H/R has been less examined. In this study, we examined whether epigallocatechin g...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.010

    authors： Hara Y,Fujino M,Adachi K,Li XK

    更新日期：2006-10-01 00:00:00

  • Xeno-kidney transplantation: from idea to reality.

    abstract：:Although kidney transplantation is a widely used therapy for chronic renal failure, not all patients can be transplanted due to the limited numbers of organ donations. A possible solution could be xenogenic kidney transplantation. Herein we have described the present state, problems and possible solutions using xenogr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2012.05.041

    authors： Ramackers W,Klose J,Winkler M

    更新日期：2012-07-01 00:00:00

  • Infections in cardiac transplant recipients: clinical and microbiological characteristics and consequences.

    abstract：INTRODUCTION:Infections are one of the main complications that cause morbidity and mortality in cardiac transplant recipients. We sought to establish the incidence of infections, identify the predisposing factors and determine their consequences. PATIENTS:A prospective study of 30 patients who received cardiac transpl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.087

    authors： Gómez-Moreno S,Lage E,Jiménez-Jambrina M,Ordóñez A,Borrego JM,Hernández A,Cayuela A,Cisneros JM

    更新日期：2006-10-01 00:00:00

  • Early expression profile of inflammatory markers and kidney allograft status.

    abstract：:Cellular rejection after renal transplantation, in general, occurs as a result of an interaction between immunologic processes that maintain graft tolerance versus allograft rejection. A potential mechanism that triggers such processes might be through the activation of the innate immune response initiated during orga...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.08.027

    authors： McDaniel DO,Rigney DA,McDaniel KY,Windham WJ,Redmond P,Williams B,Zhou X,Hawxby A,Butt F

    更新日期：2013-05-01 00:00:00

  • Addressing the challenges for improving long-term outcomes in renal transplantation.

    abstract：:Renal transplant patients lose their grafts most frequently from chronic allograft nephropathy and their lives from cardiac disease, malignancy, and infection. These are thus the challenges for renal transplant programs for this decade, just as acute rejection was the challenge of the last two decades. Most immunosupp...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.10.003

    authors： Chapman J

    更新日期：2008-12-01 00:00:00

  • Gastrointestinal complications of hepatic transplantation.

    abstract：:In this series of 150 orthotopic hepatic transplants, clinically significant gastrointestinal hemorrhage occurred in 34 patients (23%). Five patients (15%) survived this complication. Enteric perforations occurred in 20 patients following 198 biliary-enteric procedures. Only one patient survived. Enteric perforations ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Koep LJ,Starzl TE,Weil R 3rd

    更新日期：1979-03-01 00:00:00

  • Pheohyphomycotic soft tissue disease caused by Alternaria alternata in a kidney transplant patient: a case report and literature review.

    abstract：:A 61-year-old Italian man, who underwent a renal transplantation 8 years ago, receiving azathioprine, prednisone, and cyclosporine for immunosuppressive therapy, presented with a large reddish indurated plaque with a central ulcer, which was slowly enlarged, on the right knee. From the diseased tissue biopsy, a demati...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2006.11.023

    authors： Farina C,Gotti E,Parma A,Naldi L,Goglio A

    更新日期：2007-06-01 00:00:00

  • Educational system for transplant coordinators in Poland: postgraduate studies at Warsaw Medical University; 2 years of experience.

    abstract：:Donor hospital transplant coordinators play crucial roles in the donation process. There are only a few coordinators in Poland, while there are about 400 hospitals with intensive care units (ICU). Coordinators must be professionals in medical sciences, clinical psychology, law, organization, management, and statistics...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.005

    authors： Czerwiński J,Jakubowska-Winecka A,Becler R,Kubik T,Milecka A,Sekta S,Pabisiak K,Malanowski P,Rowinński W

    更新日期：2009-10-01 00:00:00

  • Attitude of Scottish residents living in southeastern Spain toward organ donation.

    abstract：BACKGROUND:Southeastern Spain is a habitual area of residence for the native population of Scotland. OBJECTIVE:To assess the attitude toward donation in the immigrant population in our regional community who were born in Scotland and to analyze the variables that influence this attitude. MATERIALS AND METHODS:A rando...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.08.099

    authors： Ríos A,Cascales P,Martínez L,Ramírez P,Sánchez J,Jarvis N,Parrilla P

    更新日期：2008-11-01 00:00:00

  • Initial report of the Korean Organ Transplant Registry: the first report of national kidney transplantation data.

    abstract：PURPOSE:A national organ transplant registry is an indispensable organizational requirement for patient care, research, and planning. Even though the Korean Network for Organ Sharing (KONOS) has established a database for a waiting list, organ allocation, and incidence of organ transplantation since 2000, an integrated...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.083

    authors： Ahn C,Koo TY,Jeong JC,Kim M,Yang J,Lee J,Min SI,Lee JE,Kim MS,Kwon OJ,Kim SJ,Kim YH,Kim YH,Choi BS,Choi SJ,Lee DH,Chung SY,Cho WH,Kim YS,Korean Organ Transplantation Registry Study Group.

    更新日期：2014-01-01 00:00:00

  • Comparison of two techniques of arterial anastomosis during adult cadaveric liver transplantation.

    abstract：:Arterial complications are a major source of morbidity and mortality after orthotopic liver transplantation (OLT). The incidence of hepatic artery thrombosis (HAT) ranges from 1.6% to 8%, with a mortality rate that ranges from 11% to 35%. We have described herein a technique of arterial anastomosis aiming to perform t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.05.008

    authors： Lorenzin D,Adani GL,Comuzzi C,Sainz-Barriga M,Benzoni E,Bresadola V,Risaliti A,Baccarani U,De Anna D

    更新日期：2007-07-01 00:00:00

  • Valgancyclovir as maintenance therapy for cytomegalovirus retinitis in a lung transplant patient--a case report.

    abstract：UNLABELLED:The purpose of this article is to report the use of valgancyclovir as maintenance therapy for cytomegalovirus (CMV) retinitis in a lung transplanted patient. RESULT:A 30-year-old woman with underlying pulmonary lymphangioleiomyomatosis received a lung transplant 1 year ago. CMV retinitis developed 4 months ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.034

    authors： Wang TJ,Lin CP,Yang CM,Lin LL

    更新日期：2004-11-01 00:00:00

  • Liver transplantation in management of alveolar echinococcosis: two case reports.

    abstract：:Hepatic alveolar echinococcosis is an infectious disease caused by the larval stage of Echinococcus multilocularis, which grows primarily in the liver of an infected person and develops as a tumorlike lesion. In advanced cases, the organisms infiltrate every organ neighboring the liver and spread hematogenously to dis...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.07.022

    authors： Moray G,Shahbazov R,Sevmis S,Karakayali H,Torgay A,Arslan G,Savas N,Yilmaz U,Haberal M

    更新日期：2009-09-01 00:00:00

  • Brain Death: Is It a Misunderstood Concept Among Nursing Students in the South of Poland?

    abstract：BACKGROUND:The objective of the present study was to analyze the knowledge and acceptance of the brain death (BD) concept among nursing students. METHODS:The study was undertaken in the academic year of 2011 to 2012 in nursing students from the University of the South of Poland. The sample was carried out in compulsor...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.10.016

    authors： Mikla M,Ríos A,López-Navas A,Kasper M,Brzostek T,Martínez-Alarcón L,Ramis G,Ramírez P,López-Montesinos MJ

    更新日期：2015-11-01 00:00:00

  • Intrathecal implants of microencapsulated xenogenic chromaffin cells provide a long-term source of analgesic substances.

    abstract：:Adrenal medullary chromaffin cells secrete several neuroactive substances including catecholamines and opioid peptides that produce analgesic effects in the central nervous system. This study was designed to investigate whether intrathecal microencapsulated chromaffin cells could release analgesic materials producing ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.098

    authors： Jeon Y,Kwak K,Kim S,Kim Y,Lim J,Baek W

    更新日期：2006-11-01 00:00:00

  • Liver transplantation in fulminant hepatic failure: experience with 40 adult patients over a 17-year period.

    abstract：INTRODUCTION:To evaluate the influence of pretransplantation recipient and donor prognostic factors on graft-patient survival. MATERIALS AND METHODS:Between April 1986 and June 2003, 40 liver transplantation (LT) procedures to treat fulminant hepatic failure were performed (5.7%). Twenty-one pre-LT recipient and donor...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.225

    authors： Montalti R,Nardo B,Beltempo P,Bertelli R,Puviani L,Cavallari A

    更新日期：2005-03-01 00:00:00

  • Use of high-dose human immune globulin in highly sensitized patients on the kidney transplant waiting list: one center's experience.

    abstract：INTRODUCTION:Transplant rates are low among highly sensitized patients with preformed anti-HLA antibodies, because of the additional immunologic barrier, the increased risk of rejection, and the greater chance of early graft loss. Intravenous infusion of pooled human immune globulin (IVIG) is immunomodulatory, neutrali...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.006

    authors： Gozdowska J,Urbanowicz A,Perkowska-Ptasinska A,Michalska K,Chmura A,Szmidt J,Durlik M

    更新日期：2009-10-01 00:00:00

  • Immunoprophylaxis with Simulect (basiliximab) in kidney transplantation: results from routine clinical practice at 18 kidney transplant units.

    abstract：OBJECTIVE:The objective of this study is to assess a Simulect (basiliximab) regimen in routine clinical practice in the Spanish kidney transplantation units to evaluate efficacy and safety. METHODS:In this prospective, observational study, data on demographics, parameters of efficacy, and safety in patients who under ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0041-1345(03)00575-x

    authors： Rengel M,Fernández Rodriguez A,Gómez Huertas E,Plaza JJ,Ruiz San Millán JC,Oppenheimer F,Bustamante J,Checa D,Sanchez Plumed JA,García Pérez J,Sanz Guajardo A,Llorente S,Martin Govantes JA,Gentil MA,Gomez Ullate P,Sanchez G

    更新日期：2003-08-01 00:00:00

  • Efficacy of ICAM-1 antisense oligonucleotide in pancreatic islet transplantation.

    abstract：:Significant islet allograft prolongation was achieved by ICAM-1/LFA-1 blockade. ICAM-1 antisense oligonucleotide IP-3082 was effective in improving islet function as well as prolonging graft survival. ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Katz SM,Browne B,Phan T,Wang ME,Bennett CF,Stepkowski SM,Kahan BD

    更新日期：1995-12-01 00:00:00