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Clinical experience of mycophenolate mofetil in the treatment of chronic allograft nephropathy in kidney transplantation: three-year follow-up.

Abstract：

BACKGROUND:Mycophenolate mofetil (MMF) in conjunction with calcineura antagonists has been shown to prevent acute rejection in renal allograft recipients. Its role in treatment of chronic rejection or allograft nephropathy is still controversial. We initiated the study to investigate the effect of adding MMF to a cyclosporine plus prednisolone regimen in renal recipients with chronic allograft nephropathy. MATERIALS AND METHODS:We retrospectively studied 36 patients with chronic allograft nephropathy, defined clinically as increased of serum creatinine, proteinuria, and hypertension. Renal function, cyclosporine level, renal biopsy, and renal scan were regularly done as indicated. MMF was added to 20 recipients after initial treatment with cyclosporine and prednisolone. The other 16 recipients were managed without adding MMF. Serum creatinine was monitored for 3 years. RESULTS:The demographic characteristics of the patients in the two groups were comparable. The average dose of prednisolone was unchanged throughout the study and the trough level of cyclosporine was maintained in the range of 100 to 150 ng/mL. The serum creatinine decreased initially in the group on MMF, but renal function deteriorated progressively after 6 months. There was a difference in serum creatinine between the two groups but this did not reach statistical significance. CONCLUSION:MMF therapy tender to improve renal function initially but did not attenuate significantly the impairment in chronic allograft nephropathy.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Chu SH,Wu CT,Chou CC,Chen Y,Liu KL,Chiang YJ

doi

10.1016/j.transproceed.2004.08.012

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

2073-5

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00867-X

journal_volume

36

pub_type

杂志文章

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