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BK Virus Nephropathy in Kidney Transplantation: An Approach Proposal and Update on Risk Factors, Diagnosis, and Treatment.

Abstract：

:BK virus belongs to Polyomaviridae family; it causes 95% of nephropathy cases related to polyomavirus, with the other 5% caused by JC virus. Nephropathy jeopardizes graft function, causing a premature failure of the graft in 1%-10% of patients with kidney transplants. Nowadays, antiviral effective treatment is unknown, which is why blood and urine screening of renal transplantation patients has become the most important recommendation to guide the decrease of immunosuppression, and the only proven method to decrease poor outcomes. Different interventions, such as cidofovir, leflunomide, fluoroquinolones, and intravenous immunoglobulin, have been attempted with no improvement at all. This review aims to summarize the most relevant features of BK virus, historical issues, transmission mechanisms, risk factors, and therapeutic interventions.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Gonzalez S,Escobar-Serna DP,Suarez O,Benavides X,Escobar-Serna JF,Lozano E

doi

10.1016/j.transproceed.2015.05.010

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

1777-85

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00524-2

journal_volume

47

pub_type

杂志文章,评审

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