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Drug interaction between tacrolimus and ertapenem in renal transplantation recipients.

Abstract：

:To show drug interactions between tacrolimus and ertapenem, we retrospectively evaluated 13 renal transplant recipients who had been treated with ertapenem for urinary tract infections during prescription of a constant dose. The mean dose of tacrolimus to achieve desired therapeutic concentrations decreased significantly after beginning ertapenem. The decrease from 0.079 mg/kg to 0.043 mg/kg occurred 2 days after initiation of ertapenem (P < .005). These results suggest that ertapenem, which is not metabolized through the cytochrome (CYP) P450 3A metabolic pathway, interacts with tacrolimus by an unknown mechanism. This report recommends tacrolimus concentration monitoring and dose reductions when the two drugs are administered in combination.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Bora F,Aliosmanoglu I,Kocak H,Dinckan A,Uslu HB,Gunseren F,Suleymanlar G

doi

10.1016/j.transproceed.2012.08.003

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

3029-32

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(12)00959-1

journal_volume

44

pub_type

杂志文章

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