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Cytomegalovirus disease after kidney transplantation: clues to accurate diagnosis.

Abstract：

BACKGROUND:The clinical diagnosis of cytomegalovirus (CMV) disease after kidney transplantation is often not accurate. We evaluated the factors associated with a correct diagnosis of CMV disease in these patients. MATERIALS AND METHODS:This retrospective study of all renal transplant patients between 2004 and 2005 with a clinical diagnosis of CMV disease included both donors and recipients who were seropositive for CMV at transplantation. We assessed the rate and correlated factors with a correct diagnosis. RESULTS:Among 127 cases, the 30 (23.6%) patients who had a correct diagnosis of CMV disease. Showed higher ages at transplantation (48.8 +/- 15.3 vs. 39.8 +/- 14.4 years; P=.004) and a shorter interval between transplantation and symptom presentation (9.7 +/- 20.7 vs. 25.6 +/- 33.6 days; P=.048). Diabetes mellitus (DM) was the cause of end-stage renal disease (ESRD) in 41% of patients with a correct diagnosis, whereas it was the cause in 11% of CMV disease-negative patients (P<.001). A multiple logistic regression model showed that DM as the cause of ESRD (P=.001; odds ratio [OR] 16.331), >5 months duration between transplantation and the presence of symptoms (P=.001; OR, 0.060), and age at transplantation >55 years (P=.022; OR, 3.833) were predictors of a correct diagnosis of CMV disease (chi(2)=46.45; P<.001). CONCLUSION:The results herein showed that considering some variables significantly improved the accuracy of a correct diagnosis of CMV disease after kidney transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Nemati E,Eizadi M,Lankarani MM,Kardavani B,Khoddami-Vishteh HR,Kalantar E,Lesan-Pezeshki M,Khedmat H,Saadat AR

doi

10.1016/j.transproceed.2007.03.087

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

987-9

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)00485-X

journal_volume

39

pub_type

杂志文章

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